Characterisation of autophagic clearance of mitochondrial damage associated molecular patterns in inflammatory bowel disease

Project Details

Description

Autophagy (or intracellular self-digestion) is central in maintaining cellular health. Major genomewide association studies have suggested that this pathway is important in the pathogenesis of the inflammatory bowel diseases, IBD (Ulcerative colitis and Crohn's disease). A major role of autophagy is directed towards the clearance of intracellular organelles such of the mitochondria. As the mitochondria are evolutionarily derived from bacteria, damaged or improperly released mitochondria are highly pro-inflammatory. We have multiple lines of evidence to show that this is important in IBD. In this study, we aim to study in detail the autophagic proteins (PINK, Parkin, p62) in intestinal sections of individuals with Ulcerative colitis and Crohn's disease in order to establish primary human data to link the importance of our functional data in IBD.
StatusFinished
Effective start/end date4/01/1631/07/16