Colorectal cancer reduction through risk stratification of screening, follow-up and treatment

2023

Association between antibiotic use during early life and early-onset colorectal cancer risk overall and according to polygenic risk and FUT2 genotypes

Jiang, F., Boakye, D., Sun, J., Wang, L., Yu, L., Zhou, X., Zhao, J., Bian, Z., Song, P., He, Y., Zhu, Y., Chen, J., Yuan, S., Song, M., Larsson, S. C., Giovannucci, E. L., Theodoratou, E., Ding, K. & Li, X., 1 Nov 2023, In: International Journal of Cancer. 153, 9, p. 1602-1611 10 p.

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Dietary inflammatory indices are not associated with inflammatory bowel disease incidence and progression

Wellens, J., Chen, J., Fu, T., Zhang, Y., Kalla, R., Satsangi, J., Theodoratou, E. & Li, X., 25 Oct 2023, (E-pub ahead of print) In: Inflammatory Bowel Diseases. 6 p., izad249.

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Exploring the cross-cancer effect of smoking and its fingerprints in blood DNA methylation on multiple cancers: a mendelian randomization study

Zhou, Y., Zhou, X., Sun, J., Wang, L., Zhao, J., Chen, J., Yuan, S., He, Y., Timofeeva, M., Spiliopoulou, A., Mesa-Eguiagaray, I., Farrington, S. M., Ding, K., Dunlop, M. G., Xiao, Q., Theodoratou, E. & Li, X., 15 Oct 2023, In: International Journal of Cancer. 153, 8, p. 1477-1486 10 p.

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National and subnational incidence, mortality and associated factors of colorectal cancer in China: A systematic analysis and modelling study

Rudan, I., Theodoratou, E., Song, P., Li, X. & Global Health Epidemiology Reference Group (GHERG), 13 Oct 2023, In: Journal of Global Health. 13, 17 p., 04096.

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Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome

Sun, J., Zhao, J., Jiang, F., Wang, L., Xiao, Q., Han, F., Chen, J., Yuan, S., Wei, J., Larsson, S. C., Zhang, H., Dunlop, M. G., Farrington, S. M., Ding, K., Theodoratou, E. & Li, X., 19 Sept 2023, In: Genome Medicine. 15, p. 75 13 p., 75.

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A rapid review on the COVID-19's global impact on breast cancer screening participation rates and volumes from January-December 2020

UNCOVER, International Partnership for Resilience in Cancer Systems (I-PaRCS), Breast Cancer Working Group 2, Lee, R., Xu, W., Dozier, M., McQuillan, R., Theodoratou, E. & Figueroa, J., 12 Sept 2023, (E-pub ahead of print) In: eLIFE. 12, e85680.

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The Global Trends in Incidence, Death, Burden and Risk Factors of Early-onset Cancer From 1990 to 2019

Zhao, J., Xu, L., Sun, J., Song, M., Wang, L., Yuan, S., Zhu, Y., Wan, Z., Larsson, S. C., Tsilidis, K. K., Dunlop, M. G., Campbell, H., Rudan, I., Song, P., Theodoratou, E., Ding, K. & Li, X., 5 Sept 2023, In: BMJ Oncology. 2, 12 p., e000049.

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Impact of COVID-19 mitigations on anxiety and depression amongst students: A systematic review

Usher Network for COVID-19 Evidence Reviews (UNCOVER) group, Lee, B., Krishan, P., Goodwin, L., Iduye, D., Farfan de los Godos, E., Fryer, J., Gallagher, K., Hair, K., O'Connell, E., Ogarrio, K., King, T., Sarica, S., Scott, E., Li, X., Song, P., Dozier, M., McSwiggan, E., Stojanovski, K., Theodoratou, E., & 1 othersMcQuillan, R., 1 Sept 2023, In: Journal of Global Health. 13, 14 p., 06035.

Research output: Contribution to journal › Review article › peer-review

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Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk

Zhou, X., Xiao, Q., Jiang, F., Sun, J., Wang, L., Yu, L., Zhou, Y., Zhao, J., Zhang, H., Yuan, S., Timofeeva, M., Spiliopoulou, A., Mesa-Eguiagaray, I., Farrington, S. M., Law, P. J., Houlston, R. S., Ding, K., Dunlop, M. G., Theodoratou, E. & Li, X., 22 Aug 2023, (E-pub ahead of print) In: British Journal of Cancer. 8 p.

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Development and Validation of Risk Prediction Models for Colorectal Cancer in Patients with Symptoms

Xu, W., Mesa Eguiagaray, I., Kirkpatrick, T., Devlin, J., Brogan, S., Turner, P., Macdonald, C., Thornton, M., Zhang, X., He, Y., Li, X., Timofeeva, M., Farrington, S., Din, F., Dunlop, M. & Theodoratou, E., 29 Jun 2023, In: Journal of personalized medicine. 13, 7, 16 p., 1065.

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Cross-cancer pleiotropic analysis identifies three novel genetic risk variants for colorectal cancer

Sun, J., Wang, L., Zhou, X., Hu, L., Yuan, S., Bian, Z., Chen, J., Zhu, Y., Farrington, S. M., Campbell, H., Ding, K., Zhang, D., Dunlop, M. G., Theodoratou, E. & Li, X., 15 Jun 2023, In: Human Molecular Genetics. 32, 12, p. 2093-2102

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Exploring the complex relationship between gut microbiota and risk of colorectal neoplasia using bidirectional Mendelian Randomization analysis

Li, W., Zhou, X., Yuan, S., Wang, L., Sun, J., Chen, J., Xiao, Q., Wan, Z., Zheng, J., Zhang, C-X., Larsson, S. C., Farrington, S. M., Law, P., Houlston, R. S., Tomlinson, I., Ding, K-F., Dunlop, M. G., Theodoratou, E. & Li, X., 1 Jun 2023, In: Cancer Epidemiology, Biomarkers & Prevention. 32, 6, p. 809-817

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Field synopsis of environmental and genetic risk factors of sporadic early-onset colorectal cancer and advanced adenoma

Zhang, R., Boakye, D., Yang, N., Zhou, X., Zhou, Y., Jiang, F., Yu, L., Wang, L., Sun, J., Yuan, S., Chen, J., Hamilton, A. C., Coleman, H. G., Larsson, S. C., Little, J., Dunlop, M. G., Giovannucci, E., Theodoratou, E. & Li, X., 23 May 2023, In: Cancer Epidemiology, Biomarkers & Prevention.

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Editorial: in search of environmental risk factors of Crohn's disease and ulcerative colitis with mendelian randomisation-authors' reply

Chen, J., Ruan, X., Yuan, S., Theodoratou, E., Satsangi, J. & Li, X., 13 Apr 2023, In: Alimentary Pharmacology and Therapeutics. 57, 9, p. 1034-1035 2 p.

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Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer

Edinburgh Colorectal Group, 1 Apr 2023, In: British Journal of Surgery. 110, 4, p. 471-480

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N6-methylandenosine-related gene expression signatures for predicting the overall survival and immune responses of patients with colorectal cancer

Yu, L., Wang, L., Sun, J., Zhou, X., Hu, Y., Hu, L., He, Y., Lin, C., Chen, J., Xu, X., Dunlop, M. G., Theodoratou, E., Ding, K. & Li, X., 3 Mar 2023, In: Frontiers in genetics. 14, p. 885930

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Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank

Wang, L., Li, X., Montazeri, A., MacFarlane, A. J., Momoli, F., Duthie, S. J., Senekal, M., Mesa Eguiagaray, I., Munger, R. G., Bennett, D., Campbell, H., Rubini, M., McNulty, H., Little, J. & Theodoratou, E., 1 Mar 2023, In: The American Journal of Clinical Nutrition (AJCN). 117, 3, p. 564-575

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Antioxidants, Minerals, and Vitamins in Relation to Crohn’s disease and Ulcerative Colitis: A Mendelian Randomization Study

Chen, J., Ruan, X., Yuan, S., Deng, M., Zhang, H., Sun, J., Yu, L., Satsangi, J., Larsson, S. C., Theodoratou, E., Wang, X. & Li, X., 1 Feb 2023, In: Alimentary Pharmacology and Therapeutics. 57, 4, p. 399-408

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Comprehensive Investigation on Associations between Dietary Intake and Blood Levels of Fatty Acids and Colorectal Cancer Risk

Lu, Y., Li, D., Wang, L., Zhang, H., Jiang, F., Zhang, R., Xu, L., Yang, N., Dai, S., Xu, X., Theodoratou, E. & Li, X., 1 Feb 2023, In: Nutrients. 15, 3, 13 p., 730.

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2022

Bi-directional Mendelian randomization analysis provides evidence for the causal involvement of dysregulation of CXCL9, CCL11 and CASP8 in the pathogenesis of ulcerative colitis

Chen, J., Zhou, Y., Sun, Y., Yuan, S., Kalla, R., Sun, J., Zhao, J., Wang, L., Chen, X., Zhou, X., Dai, S., Zhang, Y., Ho, G-T., Xia, D., Cao, Q., Liu, Z., Larsson, S. C., Wang, X., Ding, K., Halfvarson, J., & 3 othersLi, X., Theodoratou, E. & Satsangi, J., 28 Dec 2022, (E-pub ahead of print) In: Journal of Crohn's and Colitis.

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Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies

Yuan, S., Yu, L., Gou, W., Wang, L., Sun, J., Li, D., Lu, Y., Cai, X., Yu, H., Yuan, C., Zheng, J., Larsson, S. C., Theodoratou, E. & Li, X., 6 Feb 2022, In: EBioMedicine. 76, p. 103865

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Systematic review of Mendelian randomization studies on risk of cancer

Markozannes, G., Kanellopoulou, A., Dimopoulou, O., Kosmidis, D., Zhang, X., Wang, L., Theodoratou, E., Gill, D., Burgess, S. & Tsilidis, K. K., 2 Feb 2022, In: BMC Medicine. 20, 1, 41.

Research output: Contribution to journal › Review article › peer-review

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2021

The effectiveness of non-pharmaceutical interventions in reducing SARS-CoV-2 transmission and COVID-19 incidence and mortality: systematic review and meta-analysis

Talic, S., Shah, S., Wild, H., Gasevic, D., Maharaj, A., Ademi, Z., Li, X., Xu, W., Mesa Eguiagaray, I., Rostron, J., Theodoratou, E., Zhang, X., Motee, A., Liew, D. & Ilic, D., 18 Nov 2021, In: British Medical Journal (BMJ). 2021, 375, e068302.

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Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa: Topographical differences in colorectal cancer risk loci eQTLs

Vaughan‐shaw, P. G., Timofeeva, M., Ooi, L., Svinti, V., Grimes, G., Smillie, C., Blackmur, J. P., Donnelly, K., Theodoratou, E., Campbell, H., Zgaga, L., Din, F. V. N., Farrington, S. M. & Dunlop, M. G., 1 Sept 2021, In: International Journal of Cancer. 149, 5, p. 1100-1108 8 p.

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Genetically-predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian Randomization Study

Zhang, X., Theodoratou, E., Li, X., Farrington, S. M., Law, P. J., Broderick, P., Walker, M., Kimentidis, Y. C., Rees, J., Houlston, R. S., Tomlinson, I. P. M., Burgess, S., Campbell, H., Dunlop, M. G. & Timofeeva, M., 29 Jan 2021, (E-pub ahead of print) In: British Journal of Cancer.

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Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance.

He, Y., Timofeeva, M., Zhang, X., Xu, W., Din, F. V. N., Svinti MacLeod, V., Farrington, S. M., Campbell, H., Dunlop, M. G. & Theodoratou, E., 7 Jan 2021, In: International Journal of Cancer.

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2020

The effect of vitamin D supplementation on survival in patients with colorectal cancer: Systematic review and Meta-analysis of Randomised Controlled Trials

Vaughan-Shaw, P. G., Buijs, L. F., Blackmur, J. P., Theodoratou, E., Zgaga, L., Din, F. V. N., Farrington, S. M. & Dunlop, M. G., 15 Sept 2020, In: British Journal of Cancer.

Research output: Contribution to journal › Article › peer-review

Open Access

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Risk factors and risk prediction models for colorectal cancer metastasis and recurrence: an umbrella review of systematic reviews and meta-analyses of observational studies

Xu, W., He, Y., Wang, Y., Li, X., Young, J., Ioannidis, J. PA., Dunlop, M. & Theodoratou, E., 26 Jun 2020, (E-pub ahead of print) In: BMC Medicine. 18, 1, 172.

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Non-genetic biomarkers and colorectal cancer risk: umbrella review and evidence triangulation

Zhang, X., Gill, D., He, Y., Yang, T., Li, X., Monori, G., Campbell, H., Dunlop, M., Tsilidis, K. K., Timofeeva, M. & Theodoratou, E., 12 May 2020, In: Cancer Medicine.

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Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response

Vaughan-Shaw, P. G., Zgaga, L., Ooi, L. Y., Theodoratou, E., Timofeeva, M., Svinti, V., Walker, M., O'Sullivan, F., Ewing, A., Johnston, S., Din, F. V. N., Campbell, H., Farrington, S. M. & Dunlop, M. G., Jan 2020, In: Gut. 69, 1, p. 103-111 9 p.

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2019

Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer

Montazeri, Z., Li, X., Nyiraneza, C., Ma, X., Timofeeva, M., Svinti MacLeod, V., Meng, X., He, Y., Bo, Y., Morgan, S., Castellví-Bel, S., Ruiz-Ponte, C., Fernandez-Rozadilla, C., Carracedo, A., Farrington, S., Dunlop, M., Campbell, H. & Theodoratou, E., 9 Dec 2019, (E-pub ahead of print) In: Gut.

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Open Access

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Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: a large population-based cohort study.

He, Y., Theodoratou, E., Li, X., Din, F. V. N., Vaughan-Shaw, P., Svinti, V., Farrington, S. M., Campbell, H., Dunlop, M. G. & Timofeeva, M., 1 Nov 2019, In: International Journal of Cancer.

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Open Access

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Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study

Li, X., Meng, X., He, Y., Spiliopoulou, A., Timofeeva, M., Wei, W-Q., Gifford, A., Yang, T., Varley, T., Tzoulaki, I., Joshi, P., Denny, J. C., Mckeigue, P., Campbell, H. & Theodoratou, E., 18 Oct 2019, In: PLoS Medicine. 16, 10, p. e1002937

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Phenome Wide Mendelian Randomisation Study of genetically determined Vitamin D on multiple health outcomes using the UK Biobank Study

Meng, X., Li, X., Timofeeva, M., He, Y., Spiliopoulou, A., Wei, W-Q., Gifford, A., Wu, H., Varley, T., Joshi, P., Denny, J. C., Farrington, S. M., Zgaga, L., Dunlop, M. G., McKeigue, P., Campbell, H. & Theodoratou, E., 13 Sept 2019, (E-pub ahead of print) In: International Journal of Epidemiology.

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Performance of prediction models on survival outcomes of colorectal cancer with surgical resection: A systematic review and meta-analysis

He, Y., Ong, Y., Li, X., Din, F. V., Brown, E., Timofeeva, M., Wang, Z., Farrington, S. M., Campbell, H., Dunlop, M. G. & Theodoratou, E., Jun 2019, In: Surgical Oncology. 29, p. 196-202 7 p.

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2018

Gene-environment interactions and colorectal cancer risk: an umbrella review of systematic reviews and meta-analyses of observational studies

Yang, T., Li, X., Montazeri, Z., Little, J., Farrington, S., Ioannidis, J. PA., Dunlop, M., Campbell, H., Timofeeva, M. & Theodoratou, E., 11 Dec 2018, (E-pub ahead of print) In: International Journal of Cancer.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study

He, Y., Timofeeva, M., Farrington, S. M., Vaughan-Shaw, P., Svinti, V., Walker, M., Zgaga, L., Meng, X., Li, X., Spiliopoulou, A., Jiang, X., Hyppönen, E., Kraft, P., Kiel, D. P., The SUNLIGHT Consortium, Hayward, C., Campbell, A., Porteous, D., Vucic, K., Kirac, I., & 8 othersFilipovic, M., Harris, S. E., Deary, I. J., Houlston, R., Tomlinson, I. P., Campbell, H., Theodoratou, E. & Dunlop, M. G., 14 Aug 2018, In: BMC Medicine. 16, 142.

Research output: Contribution to journal › Article › peer-review

Open Access

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Plasma N-glycans in colorectal cancer risk

Doherty, M., Theodoratou, E., Walsh, I., Adamczyk, B., Stöckmann, H., Agakov, F., Timofeeva, M., Trbojević-Akmačić, I., Vučković, F., Duffy, F., McManus, C. A., Farrington, S. M., Dunlop, M. G., Perola, M., Lauc, G., Campbell, H. & Rudd, P. M., 5 Jun 2018, In: Scientific Reports. 8, 1, p. 8655

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2017

Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer

Theodoratou, E., Timofeeva, M., Li, X., Meng, X. & Ioannidis, J. P. A., 21 Aug 2017, In: Annual Review of Nutrition. 37, p. 293-320 28 p.

Research output: Contribution to journal › Article › peer-review

Colorectal cancer reduction through risk stratification of screening, follow-up and treatment

Research output

Search results