Defining the interplay between hypoxia and metabolic adaptations of the innate immune response.

Walmsley, Sarah (Principal Investigator)

School of Regeneration and Repair

Status	Finished
Effective start/end date	1/01/18 → 30/06/23

Funding

Wellcome Trust (Rcl): £1,642,424.92

2 Article

Acute hypoxia drives long-term dysfunctional neutrophil immunity
Sanchez Garcia, M. A. & Walmsley, S. R., 28 Oct 2025, In: Nature Immunology. 26, 11, p. 1861-1862 2 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Sanchez-Garcia, M. A., Sadiku, P., Ortmann, B. M., Wit, N., Negishi, Y., Coelho, P., Zhang, A., Pednekar, C., Howden, A. J. M., Griffith, D. M., Seear, R., Kindrick, J. D., Mengede, J., Cooper, G., Morrison, T., Watts, E. R., Shimeld, B. T., Reyes, L., Mirchandani, A. S. & Arienti, S. & 30 others, Xu, X., Thomson, A., Brenes, A. J., Turton, H. A., Dowey, R., Hull, R. C., Davidson-Smith, H., McLaren, A., Deans, A., Choudhury, G., Doverman, K., Hope, D., Vick, O., Woodhead, A., Petrie, I., Green, S., Rzechorzek, N. M., Turtle, L., Openshaw, P. J. M., Semple, M. G., PHOSP‐COVID Study Collaborative Group, Sproul, D., Baillie, J. K., Thompson, A. A. R., Mole, D. R., von Kriegsheim, A., Whyte, M. K. B., Mhalanga, M. M., Nathan, J. A. & Walmsley, S. R., 28 Oct 2025, In: Nature Immunology. 26, 11, p. 1903-1915 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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