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Defining the macrophage regulatory T cell axis that promotes fibrosis resolution in the liver
Iredale, John
(Principal Investigator)
Anderton, Stephen
(Co-investigator)
Forbes, Stuart
(Co-investigator)
Deanery of Clinical Sciences
University of Edinburgh
Overview
Fingerprint
Research output
(9)
Project Details
Status
Finished
Effective start/end date
1/06/12
→
28/02/18
Funding
MRC:
£1,957,180.00
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Liver Cirrhosis
Medicine & Life Sciences
100%
Fibrosis
Medicine & Life Sciences
87%
Macrophages
Medicine & Life Sciences
64%
Liver
Medicine & Life Sciences
63%
Hepatocytes
Medicine & Life Sciences
62%
Myofibroblasts
Medicine & Life Sciences
61%
Matrix Metalloproteinase 12
Medicine & Life Sciences
56%
Relaxin
Medicine & Life Sciences
51%
Research output
Research output per year
2012
2012
2020
7
Article
1
Editorial
1
Literature review
Research output per year
Research output per year
Alternatively activated macrophages promotes necrosis resolution following acute liver injury
Starkey Lewis, P.
,
Campana, L.
,
Aleksieva, N.
,
Cartwright, J. A.
,
Mackinnon, A.
,
O'Duibhir, E.
,
Kendall, T.
,
Vermeren, M.
,
Thomson, A.
,
Gadd, V.
,
Dwyer, B.
,
Aird, R.
,
Man, T-Y.
,
Rossi, A. G.
,
Forrester, L.
,
Park, B. K.
&
Forbes, S. J.
,
11 Mar 2020
, (E-pub ahead of print)
In:
Journal of Hepatology.
73
,
2
,
p. 349-360
12 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Acetaminophen
100%
Necrosis
97%
Macrophages
88%
Liver
65%
Wounds and Injuries
61%
Loss of integrin αvβ8 in murine hepatocytes accelerates liver regeneration
Greenhalgh, S.
,
Matchett, K.
,
Taylor, R.
,
Huang, K.
,
Li, J. T.
,
Saeteurn, K.
,
Donnelly, M. C.
,
Simpson, E. E. M.
,
Pollack, J. L.
,
Atakilit, A.
,
Simpson, K.
,
Maher, J. J.
,
Iredale, J.
,
Sheppard, D.
&
Henderson, N.
,
1 Feb 2019
,
In:
American Journal of Pathology.
189
,
2
,
p. 258-271
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Liver Regeneration
100%
Integrins
76%
Hepatocytes
68%
Transforming Growth Factor beta
20%
Hepatectomy
15%
Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo
Fallowfield, J. A.
,
Hayden, A. L.
,
Snowdon, V. K.
,
Aucott, R. L.
,
Stutchfield, B. M.
,
Mole, D. J.
,
Pellicoro, A.
,
Gordon-Walker, T. T.
,
Henke, A.
,
Schrader, J.
,
Trivedi, P. J.
,
Princivalle, M.
,
Forbes, S. J.
,
Collins, J. E.
&
Iredale, J. P.
,
Apr 2014
,
In:
Hepatology.
59
,
4
,
p. 1492–1504
13 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Relaxin
100%
Myofibroblasts
80%
Portal Hypertension
77%
Hepatic Stellate Cells
57%
relaxin receptors
39%