Development of a multi-marker live animal diagnostic specific to TSE disease in blood plasma which is not reliant on the presence of PrPSc

  • Barr, Janice (Principal Investigator)
  • Barron, Rona (Co-investigator)
  • Waddington, David (Principal Investigator)
  • Gill, Andy (Co-investigator)
  • McCutcheon, Sandra (Co-investigator)
  • Manson, Jean (Co-investigator)

Project Details

Description

Blood plasma samples from sheep infected with BSE and from a control non-BSE group were analysed using SELDI technology. Protein profiles were obtained and a mathematical model of disease was established. Several time points during the incubation of disease were assesed for potential application to detecting the presence of BSE in sheep.

Key findings

A mathematical model of disease was constructed for the animals showing clinical signs of disease however the number of samples available particularly for the control group limited the construction of pre-clinical models.
StatusFinished
Effective start/end date1/07/0730/06/10

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