Development of CONSORT guidance for adaptive clinical trials

The CONSORT guidance framework has immensely improved the adequate reporting of fixed sample size randomised controlled trials. However, there is no guidance tailored for the reporting of adaptive trials. Research has found deficiencies in the reporting of adaptive designs and suggested modifications to the current guidance (Stevely et al., 2015).

The aim of this current proposal is therefore to develop a CONSORT extension tailored for adaptive trials in order to improve their reporting, mitigate concerns about their use, and increase their routine uptake across the public and private sectors where appropriate.

This project aims to develop guidance to help researchers provide comprehensive and informative reports when they have conducted a particular type of clinical trial, known as an adaptive trial.