Dissecting the Genetics of Colorectal Cancer: New Quinque

Project Details

StatusFinished
Effective start/end date1/01/11 → 31/12/15

Funding

  • UK-based charities: £2,530,936.00

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  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

    Fernandez-rozadilla, C., Timofeeva, M., Chen, Z., Law, P., Thomas, M., Schmit, S., Díez-obrero, V., Hsu, L., Fernandez-tajes, J., Palles, C., Sherwood, K., Briggs, S., Svinti, V., Donnelly, K., Farrington, S., Blackmur, J., Vaughan-shaw, P., Shu, X., Long, J., Cai, Q., & 190 othersGuo, X., Lu, Y., Broderick, P., Studd, J., Huyghe, J., Harrison, T., Conti, D., Dampier, C., Devall, M., Schumacher, F., Melas, M., Rennert, G., Obón-santacana, M., Martín-sánchez, V., Moratalla-navarro, F., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S., Shin, M., Shin, A., Ahn, Y., Kim, D., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y., Jia, W., Hopper, J., Jenkins, M., Win, A. K., Pai, R., Figueiredo, J., Haile, R., Gallinger, S., Woods, M., Newcomb, P., Duggan, D., Cheadle, J., Kaplan, R., Maughan, T., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, L., Jousilahti, P., Knekt, P., Aaltonen, L., Rissanen, H., Pukkala, E., Eriksson, J., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-sinisalo, L., Zanke, B., Männistö, S., Albanes, D., Weinstein, S., Ruiz-narvaez, E., Palmer, J., Buchanan, D., Platz, E., Visvanathan, K., Ulrich, C., Siegel, E., Brezina, S., Gsur, A., Campbell, P., Chang-claude, J., Hoffmeister, M., Brenner, H., Slattery, M., Potter, J., Tsilidis, K., Schulze, M., Gunter, M., Murphy, N., Castells, A., Castellví-bel, S., Moreira, L., Arndt, V., Shcherbina, A., Stern, M., Pardamean, B., Bishop, T., Giles, G., Southey, M., Idos, G., Mcdonnell, K., Abu-ful, Z., Greenson, J., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y., Steinfelder, R., Keku, T., Van Guelpen, B., Hudson, T., Hampel, H., Pearlman, R., Berndt, S., Hayes, R., Martinez, M. E., Thomas, S., Corley, D., Pharoah, P., Larsson, S., Yen, Y., Lenz, H., White, E., Li, L., Doheny, K., Pugh, E., Shelford, T., Chan, A., Cruz-correa, M., Lindblom, A., Hunter, D., Joshi, A., Schafmayer, C., Scacheri, P., Kundaje, A., Nickerson, D., Schoen, R., Hampe, J., Stadler, Z., Vodicka, P., Vodickova, L., Vymetalkova, V., Papadopoulos, N., Edlund, C., Gauderman, W., Thomas, D., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S., Van Duijnhoven, F., Feskens, E., Sakoda, L., Gago-dominguez, M., Wolk, A., Naccarati, A., Pardini, B., Fitzgerald, L., Lee, S. C., Ogino, S., Bien, S., Kooperberg, C., Li, C., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Tangen, C., Mardis, E., Yamaji, T., Sawada, N., Iwasaki, M., Haiman, C., Le Marchand, L., Wu, A., Qu, C., Mcneil, C., Coetzee, G., Hayward, C., Deary, I., Harris, S., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Moreno, V., Casey, G., Gruber, S., Tomlinson, I., Zheng, W., Dunlop, M., Houlston, R. & Peters, U., 20 Dec 2022, (E-pub ahead of print) In: Nature Genetics.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis: a cohort study in UK Biobank

    E.W Briggs, S., Law, P., E. East, J., Wordsworth, S., Dunlop, M. G., Houlston, R., Hippisley-Cox, J. & Tomlinson, I. P. M., 9 Nov 2022, In: British Medical Journal (BMJ).

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: A Mendelian randomisation analysis

    Culliford, R., Cornish, A. J., Law, P. J., Farrington, S. M., Palin, K., Jenkins, M. A., Casey, G., Hoffmeister, M., Brenner, H., Chang-Claude, J., Kirac, I., Maughan, T., Brezina, S., Gsur, A., Cheadle, J. P., Aaltonen, L. A., Dunlop, M. G. & Houlston, R. S., 7 Jan 2021, (E-pub ahead of print) In: British Journal of Cancer.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
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