Dissecting the Genetics of Colorectal Cancer: New Quinque

2024

Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk

Law, P. J., Studd, J., Smith, J., Vijayakrishnan, J., Harris, B. T., Mandelia, M., Mills, C., Dunlop, M. G. & Houlston, R. S., 16 Sept 2024, (E-pub ahead of print) In: Nature Genetics.

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2023

Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk

Zhou, X., Xiao, Q., Jiang, F., Sun, J., Wang, L., Yu, L., Zhou, Y., Zhao, J., Zhang, H., Yuan, S., Timofeeva, M., Spiliopoulou, A., Mesa-Eguiagaray, I., Farrington, S. M., Law, P. J., Houlston, R. S., Ding, K., Dunlop, M. G., Theodoratou, E. & Li, X., 22 Aug 2023, (E-pub ahead of print) In: British Journal of Cancer. 8 p.

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Cross-cancer pleiotropic analysis identifies three novel genetic risk variants for colorectal cancer

Sun, J., Wang, L., Zhou, X., Hu, L., Yuan, S., Bian, Z., Chen, J., Zhu, Y., Farrington, S. M., Campbell, H., Ding, K., Zhang, D., Dunlop, M. G., Theodoratou, E. & Li, X., 15 Jun 2023, In: Human Molecular Genetics. 32, 12, p. 2093-2102

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Exploring the complex relationship between gut microbiota and risk of colorectal neoplasia using bidirectional Mendelian Randomization analysis

Li, W., Zhou, X., Yuan, S., Wang, L., Sun, J., Chen, J., Xiao, Q., Wan, Z., Zheng, J., Zhang, C-X., Larsson, S. C., Farrington, S. M., Law, P., Houlston, R. S., Tomlinson, I., Ding, K-F., Dunlop, M. G., Theodoratou, E. & Li, X., 1 Jun 2023, In: Cancer Epidemiology, Biomarkers & Prevention. 32, 6, p. 809-817

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2022

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Fernandez-rozadilla, C., Timofeeva, M., Chen, Z., Law, P., Thomas, M., Schmit, S., Díez-obrero, V., Hsu, L., Fernandez-tajes, J., Palles, C., Sherwood, K., Briggs, S., Svinti, V., Donnelly, K., Farrington, S., Blackmur, J., Vaughan-shaw, P., Shu, X., Long, J., Cai, Q., & 190 othersGuo, X., Lu, Y., Broderick, P., Studd, J., Huyghe, J., Harrison, T., Conti, D., Dampier, C., Devall, M., Schumacher, F., Melas, M., Rennert, G., Obón-santacana, M., Martín-sánchez, V., Moratalla-navarro, F., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S., Shin, M., Shin, A., Ahn, Y., Kim, D., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y., Jia, W., Hopper, J., Jenkins, M., Win, A. K., Pai, R., Figueiredo, J., Haile, R., Gallinger, S., Woods, M., Newcomb, P., Duggan, D., Cheadle, J., Kaplan, R., Maughan, T., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, L., Jousilahti, P., Knekt, P., Aaltonen, L., Rissanen, H., Pukkala, E., Eriksson, J., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-sinisalo, L., Zanke, B., Männistö, S., Albanes, D., Weinstein, S., Ruiz-narvaez, E., Palmer, J., Buchanan, D., Platz, E., Visvanathan, K., Ulrich, C., Siegel, E., Brezina, S., Gsur, A., Campbell, P., Chang-claude, J., Hoffmeister, M., Brenner, H., Slattery, M., Potter, J., Tsilidis, K., Schulze, M., Gunter, M., Murphy, N., Castells, A., Castellví-bel, S., Moreira, L., Arndt, V., Shcherbina, A., Stern, M., Pardamean, B., Bishop, T., Giles, G., Southey, M., Idos, G., Mcdonnell, K., Abu-ful, Z., Greenson, J., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y., Steinfelder, R., Keku, T., Van Guelpen, B., Hudson, T., Hampel, H., Pearlman, R., Berndt, S., Hayes, R., Martinez, M. E., Thomas, S., Corley, D., Pharoah, P., Larsson, S., Yen, Y., Lenz, H., White, E., Li, L., Doheny, K., Pugh, E., Shelford, T., Chan, A., Cruz-correa, M., Lindblom, A., Hunter, D., Joshi, A., Schafmayer, C., Scacheri, P., Kundaje, A., Nickerson, D., Schoen, R., Hampe, J., Stadler, Z., Vodicka, P., Vodickova, L., Vymetalkova, V., Papadopoulos, N., Edlund, C., Gauderman, W., Thomas, D., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S., Van Duijnhoven, F., Feskens, E., Sakoda, L., Gago-dominguez, M., Wolk, A., Naccarati, A., Pardini, B., Fitzgerald, L., Lee, S. C., Ogino, S., Bien, S., Kooperberg, C., Li, C., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Tangen, C., Mardis, E., Yamaji, T., Sawada, N., Iwasaki, M., Haiman, C., Le Marchand, L., Wu, A., Qu, C., Mcneil, C., Coetzee, G., Hayward, C., Deary, I., Harris, S., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Moreno, V., Casey, G., Gruber, S., Tomlinson, I., Zheng, W., Dunlop, M., Houlston, R. & Peters, U., 20 Dec 2022, (E-pub ahead of print) In: Nature Genetics.

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Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis: a cohort study in UK Biobank

E.W Briggs, S., Law, P., E. East, J., Wordsworth, S., Dunlop, M. G., Houlston, R., Hippisley-Cox, J. & Tomlinson, I. P. M., 9 Nov 2022, In: British Medical Journal (BMJ).

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2021

Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: A Mendelian randomisation analysis

Culliford, R., Cornish, A. J., Law, P. J., Farrington, S. M., Palin, K., Jenkins, M. A., Casey, G., Hoffmeister, M., Brenner, H., Chang-Claude, J., Kirac, I., Maughan, T., Brezina, S., Gsur, A., Cheadle, J. P., Aaltonen, L. A., Dunlop, M. G. & Houlston, R. S., 7 Jan 2021, (E-pub ahead of print) In: British Journal of Cancer.

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2020

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis

Cornish, A. J., Law, P. J., Timofeeva, M., Palin, K., Farrington, S. M., Palles, C., Jenkins, M. A., Casey, G., Brenner, H., Chang-Claude, J., Hoffmeister, M., Kirac, I., Maughan, T. S., Brezina, S., Gsur, A., Cheadle, J. P., Aaltonen, L. A., Tomlinson, I., Dunlop, M. G. & Houlston, R. S., 1 Jan 2020, In: The Lancet Gastroenterology & Hepatology. 5, 1, p. 55-62

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2017

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

May-wilson, S., Sud, A., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hänninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S., Palotie, A., & 34 othersRenkonen-sinisalo, L., Lepistö, A., Böhm, J., Mecklin, J., Al-tassan, N. A., Palles, C., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Fisher, D., Kerr, R., Kerr, D., Passarelli, M. N., Figueiredo, J. C., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Aaltonen, L. A., Cheadle, J. P., Tomlinson, I. P., Dunlop, M. G. & Houlston, R. S., 19 Aug 2017, In: European Journal of Cancer. 84, p. 228-238

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Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer.

Rodriguez-Broadbent, H., J. Law, P., Sud, A., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Ripatti, S., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Palotie, A., & 36 othersRenkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Farrington, S., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Passarelli, M. N., Figueiredo, J. C., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Aaltonen, L. A., Cheadle, J. P., Tomlinson, I., Dunlop, M. & Houlston, R. S., 24 Mar 2017, (E-pub ahead of print) In: International Journal of Cancer.

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2016

Glycosylation of plasma IgG in colorectal cancer prognosis

Theodoratou, E., Thaci, K., Agakov, F., Timofeeva, M., Stambuk, J., Pucic-Bakovic, M., Vuckovic, F., Orchard, P., Agakova, A., Din, F. V. N., Brown, E., Rudd, P. M., Farrington, S. M., Dunlop, M. G., Campbell, H. & Lauc, G., 15 Jun 2016, In: Scientific Reports.

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Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

Orlando, G., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Kaprio, J., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S., Palotie, A., & 37 othersJarvinen, H. J., Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Meklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Tenesa, A., Farrington, S., Timofeeva, M., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D., Win, A. K., Hopper, J. L., Jenkins, M. C., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Taipale, J., Cheadle, J. P., Dunlop, M., Tomlinson, I., Aaltonen, L. A. & Houlston, R. S., Jun 2016, In: Human Molecular Genetics. 25, 11, p. 2349-2359

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Farming, foreign holidays, and vitamin D in Orkney

Weiss, E., Zgaga, L., Read, S., Wild, S., Dunlop, M., Campbell, H., McQuillan, R. & Wilson, J., 17 May 2016, In: PLoS ONE. e0155633.

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SEMA4A variation and risk of colorectal cancer

Kinnersley, B., Chubb, D., Dobbins, S. E., Frampton, M., Buch, S., Timofeeva, M., Castellvi-Bel, S., Farrington, S., Forsti, A., Hampe, J., Hemminki, K., Hofstra, R. M. W., Northwood, E., Palles, C., Pinheiro, M., Ruiz-Ponte, C., Schafmayer, C., Teixeira, M. R., Westers, H., Van Wezel, T., & 4 othersBishop, D. T., Tomlinson, I., Dunlop, M. & Houlston, R. S., 10 Mar 2016, In: Nature Communications.

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IgG glycome in colorectal cancer

Vuckovic, F., Theodoratou, E., Thaci, K., Timofeeva, M., Vojta, A., tambuk, J., Pucic-bakovic, M., erek, L., Servis, D., Rudd, P., Wennerstrom, A., Aulchenko, Y., Farrington, S. M., Perola, M., Dunlop, M. G., Campbell, H. & Lauc, G., 1 Feb 2016, (E-pub ahead of print) In: Clinical Cancer Research.

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2015

Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Timofeeva, M. N., Kinnersley, B., Farrington, S. M., Whiffin, N., Palles, C., Svinti, V., Lloyd, A., Gorman, M., Ooi, L., Hosking, F., Barclay, E., Zgaga, L., Dobbins, S., Martin, L., Theodoratou, E., Broderick, P., Tenesa, A., Smillie, C., Grimes, G., Hayward, C., & 41 othersCampbell, A., Porteous, D., Deary, I. J., Harris, S. E., Northwood, E. L., Barrett, J. H., Smith, G., Wolf, R., Forman, D., Morreau, H., Ruano, D., Tops, C., Wijnen, J., Schrumpf, M., Boot, A., Vasen, H. F. A., Hes, F. J., Van Wezel, T., Franke, A., Lieb, W., Schafmayer, C., Hampe, J., Buch, S., Propping, P., Hemminki, K., F??rsti, A., Westers, H., Hofstra, R., Pinheiro, M., Pinto, C., Teixeira, M., Ruiz-ponte, C., Fern??ndez-rozadilla, C., Carracedo, A., Castells, A., Castellv??-bel, S., Campbell, H., Bishop, D. T., Tomlinson, I. P. M., Dunlop, M. G. & Houlston, R. S., 10 Nov 2015, In: Scientific Reports. 5, p. 16286

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Modulation of genetic associations with serum urate levels by body-mass-index in humans

Huffman, J. E., Albrecht, E., Teumer, A., Mangino, M., Kapur, K., Johnson, T., Kutalik, Z., Pirastu, N., Pistis, G., Lopez, L. M., Haller, T., Salo, P., Goel, A., Li, M., Tanaka, T., Dehghan, A., Ruggiero, D., Malerba, G., Smith, A. V., Nolte, I. M., & 100 othersPortas, L., Phipps-Green, A., Boteva, L., Navarro, P., Johansson, A., Hicks, A. A., Polasek, O., Esko, T., Peden, J. F., Harris, S. E., Murgia, F., Wild, S. H., Tenesa, A., Tin, A., Mihailov, E., Grotevendt, A., Gislason, G. K., Coresh, J., D'Adamo, P., Ulivi, S., Vollenweider, P., Waeber, G., Campbell, S., Kolcic, I., Fisher, K., Viigimaa, M., Metter, J. E., Masciullo, C., Trabetti, E., Bombieri, C., Sorice, R., Döring, A., Reischl, E., Strauch, K., Hofman, A., Uitterlinden, A. G., Waldenberger, M., Wichmann, H-E., Davies, G., Gow, A. J., Dalbeth, N., Stamp, L., Smit, J. H., Kirin, M., Nagaraja, R., Nauck, M., Schurmann, C., Budde, K., Farrington, S. M., Theodoratou, E., Jula, A., Salomaa, V., Sala, C., Hengstenberg, C., Burnier, M., Mägi, R., Klopp, N., Kloiber, S., Schipf, S., Ripatti, S., Cabras, S., Soranzo, N., Homuth, G., Nutile, T., Munroe, P. B., Hastie, N., Campbell, H., Rudan, I., Cabrera, C., Haley, C., Franco, O. H., Merriman, T. R., Gudnason, V., Pirastu, M., Penninx, B. W., Snieder, H., Metspalu, A., Ciullo, M., Pramstaller, P. P., van Duijn, C. M., Ferrucci, L., Gambaro, G., Deary, I. J., Dunlop, M. G., Wilson, J. F., Gasparini, P., Gyllensten, U., Spector, T. D., Wright, A. F., Hayward, C., Watkins, H., Perola, M., Bochud, M., Kao, W. H. L., Caulfield, M., Toniolo, D., Völzke, H., Gieger, C., Köttgen, A. & Vitart, V., 26 Mar 2015, In: PLoS ONE. 10, 3, e0119752.

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2013

Inference of identity by descent in population isolates and optimal sequencing studies

Glodzik, D., Navarro, P., Vitart, V., Hayward, C., McQuillan, R., Wild, S. H., Dunlop, M. G., Rudan, I., Campbell, H., Haley, C., Wright, A. F., Wilson, J. F. & McKeigue, P., Oct 2013, In: European Journal of Human Genetics. 21, 10, p. 1140-1145 6 p.

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Model Selection Approach Suggests Causal Association between 25-Hydroxyvitamin D and Colorectal Cancer

Zgaga, L., Agakov, F., Theodoratou, E., Farrington, S. M., Tenesa, A., Dunlop, M. G., McKeigue, P. & Campbell, H., 24 May 2013, In: PLoS ONE. 8, 5, 11 p., e63475.

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Dissecting the Genetics of Colorectal Cancer: New Quinque

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