Elucidating the Mechanism by Which the SHROOM2 Locus on Xp22.2 Contributes to Colorectal Cancer Aetiology

Project Details

StatusFinished
Effective start/end date1/10/1330/09/16

Funding

  • MRC: £1,084,794.00
  • Genome-wide asociation study and meta-analysis in Northrn European populations replicate multiple colorectal cancer risk loci: GWAS and meta-analysis of CRC

    Tanskanen, T., van den Berg, L. M., Välimäki, N., Aavikko, M., Ness-Jensen, E., Hveem, K., Wettergen, Y., Bexe Lindskog, E., Tonisson, N., Metspalu, A., Silander, K., Orlando, G., Law, P. J., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Kondelin, J., Sarin, A-P., Pukkala, E. & 40 others, Jousilahti, P., Salomaa, V., Ripatti, S., Palotie, A., Järvinen, H., Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Tenesa, A., Farrington, S., Timofeeva, M., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. C., Newcomb, P., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Cheadle, J. P., Dunlop, M., Tomlinson, I. P. M., Houlston, R. S., Palin, K. & Aaltonen, L. A., 28 Sep 2017, In: International Journal of Cancer. 142, 3, p. 540-546

    Research output: Contribution to journalArticlepeer-review

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  • SEMA4A variation and risk of colorectal cancer

    Kinnersley, B., Chubb, D., Dobbins, S. E., Frampton, M., Buch, S., Timofeeva, M., Castellvi-Bel, S., Farrington, S., Forsti, A., Hampe, J., Hemminki, K., Hofstra, R. M. W., Northwood, E., Palles, C., Pinheiro, M., Ruiz-Ponte, C., Schafmayer, C., Teixeira, M. R., Westers, H., Van Wezel, T. & 4 others, Bishop, D. T., Tomlinson, I., Dunlop, M. & Houlston, R. S., 10 Mar 2016, In: Nature Communications.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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  • Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Thompson, B. A., Spurdle, A. B., Plazzer, J., Greenblatt, M. S., Akagi, K., Al-mulla, F., Bapat, B., Bernstein, I., Capellá, G., Den Dunnen, J. T., Du Sart, D., Fabre, A., Farrell, M. P., Farrington, S. M., Frayling, I. M., Frebourg, T., Goldgar, D. E., Heinen, C. D., Holinski-feder, E., Kohonen-corish, M. & 119 others, Robinson, K. L., Leung, S. Y., Martins, A., Moller, P., Morak, M., Nystrom, M., Peltomaki, P., Pineda, M., Qi, M., Ramesar, R., Rasmussen, L. J., Royer-pokora, B., Scott, R. J., Sijmons, R., Tavtigian, S. V., Tops, C. M., Weber, T., Wijnen, J., Woods, M. O., Macrae, F., Genuardi, M., Castillejo, A., Sexton, A., Chan, A. K. W., Viel, A., Blanco, A., French, A., Laner, A., Wagner, A., Van Den Ouweland, A., Mensenkamp, A., Payá, A., Betz, B., Redeker, B., Smith, B., Espenschied, C., Cummings, C., Engel, C., Fornes, C., Valenzuela, C., Alenda, C., Buchanan, D., Barana, D., Konstantinova, D., Cairns, D., Glaser, E., Silva, F., Lalloo, F., Crucianelli, F., Hogervorst, F., Casey, G., Tomlinson, I., Blanco, I., Villar, I. L., Garcia-planells, J., Bigler, J., Shia, J., Martinez-lopez, J., Gille, J. J. P., Hopper, J., Potter, J., Soto, J. L., Kantelinen, J., Ellis, K., Mann, K., Varesco, L., Zhang, L., Le Marchand, L., Marafie, M. J., Nordling, M., Tibiletti, M. G., Kahan, M. A., Ligtenberg, M., Clendenning, M., Jenkins, M., Speevak, M., Digweed, M., Kloor, M., Hitchins, M., Myers, M., Aronson, M., Valentin, M. D., Kutsche, M., Parsons, M., Walsh, M., Kansikas, M., Zahary, M. N., Pedroni, M., Heider, N., Poplawski, N., Rahner, N., Lindor, N. M., Sala, P., Nan, P., Propping, P., Newcomb, P., Sarin, R., Haile, R., Hofstra, R., Ward, R., Tricarico, R., Bacares, R., Young, S., Chialina, S., Kovalenko, S., Gunawardena, S. R., Moreno, S., Ho, S. L., Yuen, S. T., Thibodeau, S. N., Gallinger, S., Burnett, T., Teitsch, T., Chan, T. L., Smyrk, T., Cranston, T., Psofaki, V., Steinke-lange, V. & Barbera, V., 28 Feb 2014, In: Nature Genetics. 46, 2, p. 107-115

    Research output: Contribution to journalArticlepeer-review