Solid surfaces with patterned wettability are used by many plants and animals, such as desert beetles and Lotus leaves, to manipulate droplets. In industrial processes, such as printing and air-conditioning, wettability-patterned solid surfaces suffer from droplet pinning and solid-liquid friction hindering the liquid’s mobility. But what if a solid patterned surface was replaced by a liquid patterned surface? Is it even possible to pattern the wettabillity of a liquid surface? In this proposal we will lay the foundations of how droplets interact with domains of distinct droplet-on-liquid wettability, thus developing new knowledge in fluid mechanics, surface science and soft matter