Genetics and Healthcare Initiative

Research output

Research output per year 2014 2015 2017 2019 2019

• 16 Article

Research output per year

Research output per year

Search results

• 2019

  Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

  Howard, D. M., Adams, M. J., Clarke, T-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., Alloza, C., Shen, X., Barbu, M. C., Xu, E. Y., Whalley, H. C., Marioni, R. E., Porteous, D. J., Davies, G., Deary, I. J., Hemani, G., & 20 othersBerger, K., Teismann, H., Rawal, R., Arolt, V., Baune, B. T., Dannlowski, U., Domschke, K., Tian, C., Hinds, D. A., 23andMe Research Team, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Trzaskowski, M., Byrne, E. M., Ripke, S., Smith, D. J., Sullivan, P. F., Wray, N. R., Breen, G., Lewis, C. M. & McIntosh, A. M., 31 Mar 2019, In: Nature Neuroscience. 22, 3, p. 343–352 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brain 100%
  • Meta-Analysis 100%
  • Depression 100%
  • Gene 60%
  • Genome-Wide Association Study 20%

• The neurobiology of personal control during reward learning and its relation to mood

  Romaniuk, L., Sandu, A., Waiter, G. D., Mcneil, C. J., Xueyi, S., Harris, M. A., Macfarlane, J. A., Lawrie, S. M., Deary, I. J., Murray, A. D., Delgado, M. R., Steele, J. D., Mcintosh, A. M. & Whalley, H. C., Feb 2019, In: Biological psychiatry. Cognitive neuroscience and neuroimaging. 4, 2, p. 190-199 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Reinforcement Learning 100%
  • Behavior (Neuroscience) 100%
  • Neuroscience 100%
  • Anhedonia 50%
  • Frontal Lobe 50%

• Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

  Kilpeläinen, T. O., Bentley, A. R., Noordam, R., Ju Sung, Y., Harris, S., Schwander, K., Porteous, D., Starr, J. & Deary, I., 22 Jan 2019, In: Nature Communications. p. 1-11 376 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Blood Lipids 100%
  • Physical Activity 100%
  • Cholesterol 60%
  • LHX1 60%
  • Lipid Level 40%

• Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

  Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R. D., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S., Boehnke, M., & 156 othersBots, M. L., Brazel, D. M., Chambers, J. C., Chang-claude, J., Chen, C., Corley, J., Chou, Y., David, S. P., De Boer, R. A., De Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A., Hsu, C., Iacono, W. G., Kanoni, S., Kapoor, M., Kaprio, J., Kardia, S. L., Karpe, F., Kontto, J., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Laakso, M., Lai, D., Langenberg, C., Le, N., Lettre, G., Loukola, A., Luan, J., Madden, P. A. F., Mangino, M., Marioni, R. E., Marouli, E., Marten, J., Martin, N. G., Mcgue, M., Michailidou, K., Mihailov, E., Moayyeri, A., Moitry, M., Müller-nurasyid, M., Naheed, A., Nauck, M., Neville, M. J., Nielsen, S. F., North, K., Perola, M., Pharoah, P. D. P., Pistis, G., Polderman, T. J., Posthuma, D., Poulter, N., Qaiser, B., Rasheed, A., Reiner, A., Renström, F., Rice, J., Rohde, R., Rolandsson, O., Samani, N. J., Samuel, M., Schlessinger, D., Scholte, S. H., Scott, R. A., Sever, P., Shao, Y., Shrine, N., Smith, J. A., Starr, J. M., Stirrups, K., Stram, D., Stringham, H. M., Tachmazidou, I., Tardif, J., Thompson, D. J., Tindle, H. A., Tragante, V., Trompet, S., Turcot, V., Tyrrell, J., Vaartjes, I., Van Der Leij, A. R., Van Der Meer, P., Varga, T. V., Verweij, N., Völzke, H., Wareham, N. J., Warren, H. R., Weir, D. R., Weiss, S., Wetherill, L., Yaghootkar, H., Yavas, E., Jiang, Y., Chen, F., Zhan, X., Zhang, W., Zhao, W., Zhao, W., Zhou, K., Amouyel, P., Blankenberg, S., Caulfield, M. J., Chowdhury, R., Cucca, F., Deary, I. J., Deloukas, P., Di Angelantonio, E., Ferrario, M., Ferrières, J., Franks, P. W., Frayling, T. M., Frossard, P., Hall, I. P., Hayward, C., Jansson, J., Jukema, J. W., Kee, F., Männistö, S., Metspalu, A., Munroe, P. B., Nordestgaard, B. G., Palmer, C. N. A., Salomaa, V., Sattar, N., Spector, T., Strachan, D. P., Van Der Harst, P., Zeggini, E., Saleheen, D., Butterworth, A. S., Wain, L. V., Abecasis, G. R., Danesh, J., Tobin, M. D., Vrieze, S., Liu, D. J. & Howson, J. M. M., 7 Jan 2019, (E-pub ahead of print) In: Molecular Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene Locus 100%
  • Smoking 100%
  • Single-Nucleotide Polymorphism 80%
  • Association 30%
  • Sample 10%
• 2018

  Genetic and environmental contributions to psychological resilience and coping

  Navrady, L. B., Zeng, Y., Clarke, T-K., Adams, M. J., Howard, D. M., Deary, I. J. & McIntosh, A. M., 15 Feb 2018, In: Wellcome Open Research . 3, 12, p. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetics 100%
  • Coping Behavior 100%
  • Coping Strategies 100%
  • Resilience 100%
  • Coping 60%

• Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): A questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS)

  Navrady, L., Wolters, M., MacIntyre, D., Clarke, T-K., Campbell, A., Murray, A., Evans, K., Seckl, J., Haley, C., Milburn, K., Wardlaw, J., Porteous, D., Deary, I. & McIntosh, A., 1 Feb 2018, In: International Journal of Epidemiology. 47, 1, p. 13-14g

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

  Howard, D. M., Hall, L., Hafferty, J., Zeng, Y., Adams, M. J., Clarke, T-K., Porteous, D., Nagy, R., Hayward, C., Smith, B. H., Murray, A., Ryan, N., Evans, K., Haley, C., Deary, I., Thomson, P. & McIntosh, A., 30 Nov 2017, (E-pub ahead of print) In: Translational Psychiatry. 7, 1263.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)

  Clarke, T-K., Adams, M. J., Davies, G., Howard, D. M., Hall, L. S., Padmanabhan, S., Murray, A. D., Smith, B. H., Campbell, A., Hayward, C., Porteous, D. J., Deary, I. J. & McIntosh, A. M., 31 Oct 2017, In: Molecular Psychiatry. 22, 10, p. 1376-1384 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Genetics 100%
  • Health 100%
  • Alcohol Consumption 100%
  • Genome Wide Association Study 100%

• Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data

  Gibson, J., Russ, T., Adams, M. J., Clarke, T-K., Howard, D. M., Hall, L., Fernandez-Pujals, A. M., Wigmore, E., Hayward, C., Davies, G., Murray, A., Smith, B. H., Porteous, D., Deary, I. & McIntosh, A., 18 Apr 2017, In: Translational Psychiatry. 7, 4, e1094.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alzheimer's Disease 100%
  • Association 100%
  • Major Depressive Episode 100%
  • Genetic Architecture 100%
  • Major Depressive Disorder 100%

• Genetic effects influencing risk for major depressive disorder in China and Europe

  Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S-A., Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschøn, H. N., Byrne, E. M., Cichon, S., Clarke, T-K., Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C., Degenhardt, F., & 77 othersDunn, E. C., Edwards, A. C., Fanous, A. H., Forstner, A. J., Frank, J., Gill, M., Gordon, S. D., Grabe, H. J., Hamilton, S. P., Hardiman, O., Hayward, C., Heath, A. C., Henders, A. K., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Hottenga, J-J., Ising, M., Jansen, R., Kloiber, S., Knowles, J. A., Lang, M., Li, Q. S., Lucae, S., MacIntyre, D. J., Madden, P. A. F., Martin, N. G., McGrath, P. J., McGuffin, P., McIntosh, A. M., Medland, S. E., Mehta, D., Middeldorp, C. M., Milaneschi, Y., Montgomery, G. W., Mors, O., Müller-Myhsok, B., Nauck, M., Nyholt, D. R., Nöthen, M. M., Owen, M. J., Penninx, B. W. J. H., Pergadia, M. L., Perlis, R. H., Peyrot, W. J., Porteous, D. J., Potash, J. B., Rice, J. P., Rietschel, M., Riley, B. P., Rivera, M., Schoevers, R., Schulze, T. G., Shi, J., Shyn, S. I., Smit, J. H., Smoller, J. W., Streit, F., Strohmaier, J., Teumer, A., Treutlein, J., Van der Auwera, S., van Grootheest, G., van Hemert, A. M., Völzke, H., Webb, B. T., Weissman, M. M., Wellmann, J., Willemsen, G., Witt, S. H., Levinson, D. F., Lewis, C. M., Wray, N. R., Flint, J., Sullivan, P. F. & Kendler, K. S., 28 Mar 2017, In: Translational Psychiatry. 7, 3, p. e1074

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Determinism 100%
  • Major Depressive Disorder 100%
  • Single-Nucleotide Polymorphism 37%
  • Genetic Correlation 25%
  • Gene 25%

• A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway is Associated with Major Depressive Disorder

  Zeng, Y., Navarro, P., Fernandez-pujals, A. M., Hall, L. S., Clarke, T., Thomson, P. A., Smith, B. H., Hocking, L. J., Padmanabhan, S., Hayward, C., Macintyre, D. J., Wray, N. R., Deary, I., Porteous, D. J., Haley, C. S. & Mcintosh, A. M., 15 Feb 2017, In: Biological Psychiatry. 81, 4, p. 336-346

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Analysis 100%
  • Major Depressive Episode 100%
  • Heritability 100%
  • Major Depressive Disorder 100%
  • Association 23%
• 2016

  Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

  Johnson, M. R., Shkura, K., Langley, S. R., Delahaye-Duriez, A., Srivastava, P., Hill, W. D., Rackham, O. J. L., Davies, G., Harris, S. E., Moreno-Moral, A., Rotival, M., Speed, D., Petrovski, S., Katz, A., Hayward, C., Porteous, D. J., Smith, B. H., Padmanabhan, S., Hocking, L. J., Starr, J. M., & 14 othersLiewald, D. C., Visconti, A., Falchi, M., Bottolo, L., Rossetti, T., Danis, B., Mazzuferi, M., Foerch, P., Grote, A., Helmstaedter, C., Becker, A. J., Kaminski, R. M., Deary, I. J. & Petretto, E., 29 Feb 2016, In: Nature Neuroscience. 19, 2, p. 223-232 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognition 100%
  • Gene 100%
  • Brain 40%
  • Gene Regulatory Network 40%
  • Encephalopathy 20%
• 2015

  Homozygous loss-of-function variants in European cosmopolitan and isolate populations

  Generation Scotland, UK10K, Kaiser, V. B., Svinti, V., Prendergast, J. G., Chau, Y-Y., Campbell, A., Patarcic, I., Barroso, I., Joshi, P. K., Hastie, N. D., Miljkovic, A., Taylor, M. S., Enroth, S., Memari, Y., Kolb-Kokocinski, A., Wright, A. F., Gyllensten, U., Durbin, R., Rudan, I., & 11 othersCampbell, H., Polašek, O., Johansson, Å., Sauer, S., Porteous, D. J., Fraser, R. M., Drake, C., Vitart, V., Hayward, C., Semple, C. A. & Wilson, J. F., 14 Jul 2015, In: Human Molecular Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nested Gene 100%
  • Gene Function 75%
  • Human 50%
  • Loss of Function Mutation 50%
  • Sample 25%

• Current Versus Lifetime Depression, APOE Variation, and Their Interaction on Cognitive Performance in Younger and Older Adults

  Generation Scotland, Luciano, M., Pujals, A. M. F., Marioni, R. E., Campbell, A., Hayward, C., MacIntyre, D. J., Porteous, D. J., McIntosh, A. M. & Deary, I. J., 13 Jun 2015, In: Psychosomatic Medicine: Journal of Biobehavioral Medicine. 77, 5, p. 480-492 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Young Adult 100%
  • Lifespan 100%
  • Older Adult 100%
  • Cognitive Performance 100%
  • Depression 100%

• Recent genomic heritage in Scotland

  Generation Scotland, Amador, C., Huffman, J., Trochet, H., Campbell, A., Porteous, D., Wilson, J. F., Hastie, N., Vitart, V., Hayward, C., Navarro, P. & Haley, C. S., 6 Jun 2015, In: BMC Genomics. 16, 1, 437.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Family Health 100%
  • Inheritance 100%
  • Sample 50%
  • Health 50%
  • Autosome 25%
• 2014

  Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study

  Generation Scotland, 23 Jun 2014, In: BMC Medical Genetics. 15, 1, p. 70

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Screening 100%
  • Next Generation Sequencing 100%
  • Cholesterol 87%
  • Combination Therapy 37%
  • Clinical Significance 25%