Genetics & healthcare initiative

2017

Balancing the local and the universal in maintaining ethical access to a genomics biobank

Heeney, C. & Kerr, S., 28 Dec 2017, In: BMC Medical Ethics. 18, 1, p. 1-11 11 p.

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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-costa, N. L., Den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renström, F., Quaye, L., Eicher, J. D., & 262 othersHayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-vidal, P. M., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, J. M., Kleber, M. E., Hollensted, M., Lohman, K., Rivera, N. V., Whitfield, J. B., Zhao, J. H., Stringham, H. M., Lyytikäinen, L., Huppertz, C., Willemsen, G., Peyrot, W. J., Wu, Y., Kristiansson, K., Demirkan, A., Fornage, M., Hassinen, M., Bielak, L. F., Cadby, G., Tanaka, T., Mägi, R., Van Der Most, P. J., Jackson, A. U., Bragg-gresham, J. L., Vitart, V., Marten, J., Navarro, P., Bellis, C., Pasko, D., Johansson, Å., Snitker, S., Cheng, Y., Eriksson, J., Lim, U., Aadahl, M., Adair, L. S., Amin, N., Balkau, B., Auvinen, J., Beilby, J., Bergman, R. N., Bergmann, S., Bertoni, A. G., Blangero, J., Bonnefond, A., Bonnycastle, L. L., Borja, J. B., Brage, S., Busonero, F., Buyske, S., Campbell, H., Chines, P. S., Collins, F. S., Corre, T., Smith, G. D., Delgado, G. E., Dueker, N., Dörr, M., Ebeling, T., Eiriksdottir, G., Esko, T., Faul, J. D., Fu, M., Færch, K., Gieger, C., Gläser, S., Gong, J., Gordon-larsen, P., Grallert, H., Grammer, T. B., Grarup, N., Van Grootheest, G., Harald, K., Hastie, N. D., Havulinna, A. S., Hernandez, D., Hindorff, L., Hocking, L. J., Holmens, O. L., Holzapfel, C., Hottenga, J. J., Huang, J., Huang, T., Hui, J., Huth, C., Hutri-kähönen, N., James, A. L., Jansson, J., Jhun, M. A., Juonala, M., Kinnunen, L., Koistinen, H. A., Kolcic, I., Komulainen, P., Kuusisto, J., Kvaløy, K., Kähönen, M., Lakka, T. A., Launer, L. J., Lehne, B., Lindgren, C. M., Lorentzon, M., Luben, R., Marre, M., Milaneschi, Y., Monda, K. L., Montgomery, G. W., De Moor, M. H. M., Mulas, A., Müller-nurasyid, M., Musk, A. W., Männikkö, R., Männistö, S., Narisu, N., Nauck, M., Nettleton, J. A., Nolte, I. M., Oldehinkel, A. J., Olden, M., Ong, K. K., Padmanabhan, S., Paternoster, L., Perez, J., Perola, M., Peters, A., Peters, U., Peyser, P. A., Prokopenko, I., Puolijoki, H., Raitakari, O. T., Rankinen, T., Rasmussen-torvik, L. J., Rawal, R., Ridker, P. M., Rose, L. M., Rudan, I., Sarti, C., Sarzynski, M. A., Savonen, K., Scott, W. R., Sanna, S., Shuldiner, A. R., Sidney, S., Silbernagel, G., Smith, B. H., Smith, J. A., Snieder, H., Stančáková, A., Sternfeld, B., Swift, A. J., Tammelin, T., Tan, S., Thorand, B., Thuillier, D., Vandenput, L., Vestergaard, H., Van Vliet-ostaptchouk, J. V., Vohl, M., Völker, U., Waeber, G., Walker, M., Wild, S., Wong, A., Wright, A. F., Zillikens, M. C., Zubair, N., Haiman, C. A., Lemarchand, L., Gyllensten, U., Ohlsson, C., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pérusse, L., Wilson, J. F., Hayward, C., Polasek, O., Cucca, F., Hveem, K., Hartman, C. A., Tönjes, A., Bandinelli, S., Palmer, L. J., Kardia, S. L. R., Rauramaa, R., Sørensen, T. I. A., Tuomilehto, J., Salomaa, V., Penninx, B. W. J. H., De Geus, E. J. C., Boomsma, D. I., Lehtimäki, T., Mangino, M., Laakso, M., Bouchard, C., Martin, N. G., Kuh, D., Liu, Y., Linneberg, A., März, W., Strauch, K., Kivimäki, M., Harris, T. B., Gudnason, V., Völzke, H., Qi, L., Järvelin, M., Chambers, J. C., Kooner, J. S., Froguel, P., Kooperberg, C., Vollenweider, P., Hallmans, G., Hansen, T., Pedersen, O., Metspalu, A., Wareham, N. J., Langenberg, C., Weir, D. R., Porteous, D. J., Boerwinkle, E., Chasman, D. I., Abecasis, G. R., Barroso, I., Mccarthy, M. I., Frayling, T. M., O’connell, J. R., Van Duijn, C. M., Boehnke, M., Heid, I. M., Mohlke, K. L., Strachan, D. P., Fox, C. S., Liu, C., Hirschhorn, J. N., Klein, R. J., Johnson, A. D., Borecki, I. B., Franks, P. W., North, K. E., Cupples, L. A., Loos, R. J. F., Kilpeläinen, T. O. & Edwards, T. L. (ed.), 27 Apr 2017, In: PLoS Genetics. 13, 4, p. e1006528 26 p.

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Genetic stratification to identify risk groups for Alzheimer's disease

Marioni, R., Campbell, A., Hagenaars, S., Nagy, R., Amador, C., Hayward, C., Porteous, D., Visscher, P. M. & Deary, I., 4 Mar 2017, In: Journal of Alzheimer's Disease. 57, 1, p. 275-283 8 p.

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2016

Genetic variants linked to education predict longevity

Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., Hill, W. D., Davies, G., Nagy, R., Amador, C., Läll, K., Metspalu, A., Liewald, D. C., Campbell, A., Wilson, J. F., Hayward, C., Esko, T., Porteous, D. J., Gale, C. R., & 13 othersDeary, I. J., Social Science Genetic Association Consortium, Nagy, R., Amador, C., Läll, K., Metspalu, A., Liewald, D., Campbell, A., Wilson, J. F., Hayward, C., Esko, T., Porteous, D. J. & Gale, C. V., 22 Nov 2016, In: Proceedings of the National Academy of Sciences (PNAS). 113, 47, p. 13366-13371 6 p.

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Dissection of Major Depressive Disorder using polygenic risk scores for Schizophrenia in two independent cohorts

Sibley, H., Adams, M., Hall, L. S., Clarke, T-K., Fernandez-Pujals, A. M., Gibson, J., Wigmore, E., Hafferty, J., Hagenaars, S., Davies, G., Campbell, A., Hayward, C., Lawrie, S., Porteous, D., Deary, I. & McIntosh, A., 1 Nov 2016, (E-pub ahead of print) In: Translational Psychiatry. 6, 11, p. e938

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Polygenic risk for coronary artery disease is associated with cognitive ability in older adults

Generation Scotland, Hagenaars, S. P., Harris, S. E., Clarke, T-K., Hall, L., Luciano, M., Fernandez-Pujals, A. M., Davies, G., Hayward, C., Starr, J. M., Porteous, D. J., McIntosh, A. M. & Deary, I. J., 28 Jan 2016, In: International Journal of Epidemiology. 45, 2, p. 433-440

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2015

Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Timofeeva, M. N., Kinnersley, B., Farrington, S. M., Whiffin, N., Palles, C., Svinti, V., Lloyd, A., Gorman, M., Ooi, L., Hosking, F., Barclay, E., Zgaga, L., Dobbins, S., Martin, L., Theodoratou, E., Broderick, P., Tenesa, A., Smillie, C., Grimes, G., Hayward, C., & 41 othersCampbell, A., Porteous, D., Deary, I. J., Harris, S. E., Northwood, E. L., Barrett, J. H., Smith, G., Wolf, R., Forman, D., Morreau, H., Ruano, D., Tops, C., Wijnen, J., Schrumpf, M., Boot, A., Vasen, H. F. A., Hes, F. J., Van Wezel, T., Franke, A., Lieb, W., Schafmayer, C., Hampe, J., Buch, S., Propping, P., Hemminki, K., F??rsti, A., Westers, H., Hofstra, R., Pinheiro, M., Pinto, C., Teixeira, M., Ruiz-ponte, C., Fern??ndez-rozadilla, C., Carracedo, A., Castells, A., Castellv??-bel, S., Campbell, H., Bishop, D. T., Tomlinson, I. P. M., Dunlop, M. G. & Houlston, R. S., 10 Nov 2015, In: Scientific Reports. 5, p. 16286

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Homozygous loss-of-function variants in European cosmopolitan and isolate populations

Generation Scotland, UK10K, Kaiser, V. B., Svinti, V., Prendergast, J. G., Chau, Y-Y., Campbell, A., Patarcic, I., Barroso, I., Joshi, P. K., Hastie, N. D., Miljkovic, A., Taylor, M. S., Enroth, S., Memari, Y., Kolb-Kokocinski, A., Wright, A. F., Gyllensten, U., Durbin, R., Rudan, I., & 11 othersCampbell, H., Polašek, O., Johansson, Å., Sauer, S., Porteous, D. J., Fraser, R. M., Drake, C., Vitart, V., Hayward, C., Semple, C. A. & Wilson, J. F., 14 Jul 2015, In: Human Molecular Genetics.

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Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index

Clarke, T-K., Hall, L. S., Fernandez-Pujals, A. M., MacIntyre, D. J., Thomson, P., Hayward, C., Smith, B. H., Padmanabhan, S., Hocking, L. J., Deary, I. J., Porteous, D. J. & McIntosh, A. M., 30 Jun 2015, In: Translational Psychiatry. 5, e592.

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Current Versus Lifetime Depression, APOE Variation, and Their Interaction on Cognitive Performance in Younger and Older Adults

Generation Scotland, Luciano, M., Pujals, A. M. F., Marioni, R. E., Campbell, A., Hayward, C., MacIntyre, D. J., Porteous, D. J., McIntosh, A. M. & Deary, I. J., 13 Jun 2015, In: Psychosomatic Medicine: Journal of Biobehavioral Medicine. 77, 5, p. 480-492 13 p.

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Recent genomic heritage in Scotland

Generation Scotland, Amador, C., Huffman, J., Trochet, H., Campbell, A., Porteous, D., Wilson, J. F., Hastie, N., Vitart, V., Hayward, C., Navarro, P. & Haley, C. S., 6 Jun 2015, In: BMC Genomics. 16, 1, 437.

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Structural brain MRI trait polygenic score prediction of cognitive abilities

Generation Scotland & SINAPSE Collaborative Grp, 2015, In: Twin Research and Human Genetics. 18, p. 738-745 8 p.

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