Research output per year
Research output per year
Project Details
Description
The use of whole genome sequencing of S. aureus strains of animal origin to investigate the evolutionary history of S. aureus associated with humans and animals. Investigation into the genetic processes underlying adaptation to different species. Examination of the frequency of host-switching events by contemporary strains of S. aureus and during evolutionary time.
Key findings
Host-switching from livestock by Staphylococcus aureus results in the emergence of new clones which are pathogenic for humans.
Endemic livestock clones of S. aureus originated in humans.
Some clones of S. aureus are highly promiscuous and have disseminated to many different host species e.g. CC133
Mobile genetic elements are markers for specific host-species and contribute to host-specificity
Mutations in the core genome can play a critical role in adaptation to new species eg SNP in dltB required for infection of rabbits
Avian strains of Staphylococcus aureus contain a subfamily of beta-converting phages with an avian-specific immune evasion cluster (IEC)
Endemic livestock clones of S. aureus originated in humans.
Some clones of S. aureus are highly promiscuous and have disseminated to many different host species e.g. CC133
Mobile genetic elements are markers for specific host-species and contribute to host-specificity
Mutations in the core genome can play a critical role in adaptation to new species eg SNP in dltB required for infection of rabbits
Avian strains of Staphylococcus aureus contain a subfamily of beta-converting phages with an avian-specific immune evasion cluster (IEC)
| Status | Finished |
|---|---|
| Effective start/end date | 14/11/11 → 18/02/15 |
Funding
- BBSRC: £420,385.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Bovine Staphylococcus aureus superantigens stimulate the entire T 2 cell repertoire of cattle.
Wilson, G., Tuffs, S., Wee, B. A., Seo, K. S., Park, N., Connelley, T., Guinane, C. M., Morrison, W. & Fitzgerald, J., Nov 2018, In: Infection and Immunity. 86, 11, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Genomics of Natural Populations of Staphylococcus aureus
Fitzgerald, J. R. & Holden, M. T. G., Sept 2016, In: Annual Review of Microbiology. 70, p. 459-478Research output: Contribution to journal › Literature review
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Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation
Spoor, L. E., Richardson, E., Richards, A. C., Wilson, G. J., Mendonca, C., Gupta, R. K., Mcadam, P. R., Nutbeam-tuffs, S., Black, N. S., O'gara, J. P., Lee, C. Y., Corander, J. & Fitzgerald, R., 13 Oct 2015, In: Microbial Genomics. 1, 4Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Emma Raftis PDRA Dataset
Fitzgerald, J. (Creator), Raftis, E. (Creator), Bacigalupe, R. (Depositor) & Simpson, C. (Data Manager), Edinburgh DataVault, 2017
DOI: 10.7488/06783dbe-019d-4503-8eb2-2ae1ae85e87e
Dataset
Activities
- 4 Participation in conference
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ASM-ESCMID conference on MRSA in animals
Fitzgerald, R. (Keynote/plenary speaker)
Nov 2013Activity: Participating in or organising an event types › Participation in conference
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Gordon conference on staphylocccal diseases
Fitzgerald, R. (Invited speaker)
Jul 2013Activity: Participating in or organising an event types › Participation in conference
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Systems Biology of Infection
Fitzgerald, R. (Invited speaker)
23 Jun 2013Activity: Participating in or organising an event types › Participation in conference