High-Sensitivity Cardiac Troponin and Coronary Heart Disease

2023

Sex-differences in oral anticoagulation therapy in patients hospitalized with atrial fibrillation: a nationwide cohort study

Lee, K. K., Doudesis, D., Bing, R., Astengo, F., R. Perez, J., Anand, A., McIntyre, S., Bloor, N., Sandler, B., Lister, S., Pollock, K. G. J., Qureshi, A. C., McAllister, D. A., Shah, A. SV. & Mills, N. L., 2 Mar 2023, (E-pub ahead of print) In: Journal of the American Heart Association.

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2022

Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis

Farrah, T. E., Melville, V., Czopek, A., Fok, H., Bruce, L., Mills, N. L., Bailey, M. A., Webb, D. J., Dear, J. W. & Dhaun, N., 1 Nov 2022, In: Kidney International. 102, p. 1115-1126 12 p.

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Reference ranges for NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) and risk factors for higher NT-proBNP concentrations in a large general population cohort

Welsh, P., Campbell, R. T., Mooney, L., Kimenai, D. M., Hayward, C., Campbell, A., Porteous, D., Mills, N. L., Lang, N., Petrie, M. C., Januzzi, J. L., McMurray, J. J. V. & Sattar, N. A., 13 Sept 2022, (E-pub ahead of print) In: Circulation: Heart failure. 15, 11 p., e009427.

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High-sensitivity Cardiac Troponin Is Not Associated with Acute Cellular Rejection after Heart Transplantation

Fitzsimons, S. J., Evans, J. D. W., Rassl, D. M., Lee, K. K., Strachan, F. E., Parameshwar, J., Mills, N. L. & Pettit, S. J., 1 May 2022, In: Transplantation. 106, 5, p. 1024-1030 7 p.

Research output: Contribution to journal › Article › peer-review

Hepatosteatosis and atherosclerotic plaque on coronary computed tomography angiography

Carter, J., Heseltine, T. D., Meah, M. N., Tzolos, E., Kwiecinski, J., Doris, M., McElhinney, P., Moss, A. J., Adamson, P. D., Hunter, A. L., Alam, S., Shah, A. S. V., Pawade, T., Wang, C., Weir-McCall, J. R., Roditi, G., van Beek, E. J. R., Nicol, E. D., Shaw, L. J., Berman, D. S., & 7 othersSlomka, P. J., Mills, N. L., Dweck, M. R., Newby, D. E., Murray, S. W., Dey, D. & Williams, M. C., 28 Apr 2022, In: Radiology: Cardiothoracic Imaging.

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Pericoronary adipose tissue attenuation, low-attenuation plaque burden and 5-year risk of myocardial infarction

Tzolos, E., Williams, M. C., McElhinney, P., Lin, A., Grodecki, K., Flores Tomasino, G., Cadet, S., Kwiecinski, J., Doris, M., Adamson, P. D., Moss, A. J., Alam, S., Hunter, A., Shah, A. S. V., Mills, N. L., Pawade, T., Wang, C., Weir-McCall, J. R., Roditi, G., van Beek, E. J. R., & 7 othersShaw, L. J., Nicol, E. D., Berman, D. S., Slomka, P. J., Dweck, M. R., Newby, D. E. & Dey, D., 13 Apr 2022, In: JACC: Cardiovascular Imaging. 15, 6, p. 1078-1088

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High-Sensitivity Cardiac Troponin and the Diagnosis of Myocardial Infarction in Patients with Renal Impairment

High-STEACS Investigators, Gallacher, P. J., Miller-Hodges, E., Shah, A. S. V., Farrah, T., Halbesma, N., Blackmur, J. P., Chapman, A. R., Adamson, P. D., Anand, A., Strachan, F. E., Ferry, A. V., Lee, K. K., Berry, C., Findlay, I., Cruickshank, A., Reid, A., Gray, A., Collinson, P. O., Apple, F. S., & 8 othersMcAllister, D. A., Maguire, D., Fox, K. AA., Keerie, C., Weir, C. J., Newby, D. E., Mills, N. L. & Dhaun, N., 7 Mar 2022, In: Kidney International.

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2021

Infective endocarditis hospitalizations & outcomes in patients with end-stage kidney disease: a nationwide data-linkage study

Gallacher, P. J., McAllister, D. A., Mills, N. L., Cruden, N. L., Shah, A. S. V. & Dhaun, N., 28 Sept 2021, In: Journal of the American Heart Association.

Research output: Contribution to journal › Article › peer-review

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Association of coronary artery calcium score with qualitatively and quantitatively assessed adverse plaque on coronary CT angiography in the SCOT-HEART trial

Osborne-Grinter, M., Kwiecinski, J., Doris, M., McElhinney, P., Cadet, S., Adamson, P. D., Moss, A. J., Alam, S., Hunter, A. L., Shah, A. S. V., Mills, N. L., Pawade, T., Wang, C., Weir-McCall, J. R., Roditi, G., van Beek, E. J. R., Shaw, L. J., Nicol, E., Berman, D. S., Slomka, P. J., & 4 othersNewby, D. E., Dweck, M. R., Dey, D. & Williams, M. C., 16 Sept 2021, In: European Heart Journal - Cardiovascular Imaging.

Research output: Contribution to journal › Article › peer-review

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Risk factors for type 1 and type 2 myocardial infarction

High-STEACS Investigators, 25 Aug 2021, (E-pub ahead of print) In: European Heart Journal.

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Generation of a Novel In Vitro Model to Study Endothelial Dysfunction from Atherothrombotic Specimens

Gallogly, S., Fujisawa, T., Hung, J. D., Brittan, M., Skinner, E. M., Mitchell, A. J., Medine, C., Luque, N., Zodda, E., Cascante, M., Hadoke, P. W., Mills, N. L. & Tura-Ceide, O., 20 Feb 2021, (E-pub ahead of print) In: Cardiovascular Drugs and Therapy.

Research output: Contribution to journal › Article › peer-review

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2020

Adverse health effects associated with household air pollution: a systematic review, meta-analysis and burden estimation study

Lee, K. K., Bing, R., Kiang, J., Bashir, S., Spath, N., Stelzle, D., Mortimer, K., Bularga, A., Doudesis, D., Joshi, S., Strachan, F., Bonjour, S., Adair-Rohani, H., Attia, E. F., Chung, M. H., Miller, M., Newby, D. E., Mills, N. L., Mcallister, D. & Shah, A. S. V., 1 Nov 2020, (E-pub ahead of print) In: The Lancet Global Health. 8, 11, p. e1427-e1434 8 p.

Research output: Contribution to journal › Article › peer-review

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Coronary Vasospasm in Eosinophilic Granulomatosis with Polyangiitis

Chapman, F., Dhaun, N., Dweck, M. R. & Mills, N. L., 5 Aug 2020, In: Rheumatology.

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Ticagrelor to Reduce Myocardial Injury in Patients With High-Risk Coronary Artery Plaque

Moss, A. J., Dweck, M. R., Doris, M. K., Andrews, J. P. M., Bing, R., O. Forsythe, R., Cartlidge, T. R., Pawade, T. A., Daghem, M., Raftis, J. B., Williams, M. C., van Beek, E. J. R., Forsyth, L., Lewis, S. C., Lee, R. J., Shah, A. S. V., Mills, N. L., Newby, D. E. & Adamson, P. D., Jul 2020, In: Journal of the American College of Cardiology. 13, 7, p. 1549-1560

Research output: Contribution to journal › Article › peer-review

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Cardiac biomarkers of prognostic importance in chronic obstructive pulmonary disease

Nilsson, U., Mills, N. L., Mcallister, D. A., Backman, H., Stridsman, C., Hedman, L., Rönmark, E., Fujisawa, T., Blomberg, A. & Lindberg, A., 26 Jun 2020, In: Respiratory research. 21, 1

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Performance of the GRACE 2.0 score in patients with type 1 and type 2 myocardial infarction

Hung, J., Roos, A., Kadesjo, E., McAllister, D., Kimenai, D. M., Shah, A. S., Anand, A., Strachan, F., Fox, K., Mills, N., Chapman, A. & Holzmann, M., 9 Jun 2020, In: European Heart Journal. n/a, p. 1-10 ehaa375.

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Incidence, microbiology and outcomes in patient hospitalized with infective endocarditis

Shah, A., Mcallister, D., Gallacher, P., Astengo, F., Rodriguez Perez, J. A., Hall, J., Lee, K. K., Bing, R., Anand, A., Nathwani, D., Mills, N., Newby, D., Marwick, C. & Cruden, N., 15 May 2020, In: Circulation.

Research output: Contribution to journal › Article › peer-review

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Dynamic Changes in High-Sensitivity Cardiac Troponin I in Response to Anthracycline-Based Chemotherapy

Tzolos, E., Adamson, P. D., Hall, P. S., Macpherson, I. R., Oikonomidou, O., MacLean, M., Lewis, S. C., McVicars, H., Newby, D. E., Mills, N. L., Lang, N. N. & Henriksen, P. A., May 2020, In: Clinical Oncology. 32, 5, p. 292-297 6 p.

Research output: Contribution to journal › Article › peer-review

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Determinants and prognostic value of echocardiographic first-phase ejection fraction in aortic stenosis

Bing, R., Gu, H., Chin, C., Fang, L., White, A., Everett, R. J., Spath, N. B., Park, E., Jenkins, W. S. A., Shah, A. S. V., Mills, N. L., Flapan, A. D., Chambers, J. B., Newby, D., Chowienczyk, P. & Dweck, M., 28 Apr 2020, (E-pub ahead of print) In: Heart.

Research output: Contribution to journal › Article › peer-review

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High-Sensitivity Cardiac Troponin Can Be An Ally in the Fight Against COVID-19

Chapman, A. R., Bularga, A. & Mills, N. L., 6 Apr 2020, In: Circulation.

Research output: Contribution to journal › Article › peer-review

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Frailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction

Anand, A., Cudmore, S., Robertson, S., Stephen, J., Haga, K., Weir, C. J., Murray, S. A., Boyd, K., Gunn, J., Iqbal, J., Maclullich, A., Shenkin, S. D., Fox, K. A. A., Mills, N. & Denvir, M. A., 13 Mar 2020, In: BMC Geriatrics. 20, 1

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Validation of European Society of Cardiology pre-test probabilities for obstructive coronary artery disease in suspected stable angina

Bing, R., Singh, T., Dweck, M. R., Mills, N. L., Williams, M. C., Adamson, P. D. & Newby, D. E., 24 Jan 2020, In: European Heart Journal - Quality of Care and Clinical Outcomes.

Research output: Contribution to journal › Article › peer-review

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2019

Diagnosing myocardial infarction in the era of high-sensitivity troponin: the High-STEACS trial

Anand, A. & Mills, N., 7 Nov 2019, (E-pub ahead of print) In: Cardiovascular Research.

Research output: Contribution to journal › Article › peer-review

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High-sensitivity troponin and the application of risk stratification thresholds in patients with suspected acute coronary syndrome

High-STEACS Investigators, Bularga, A., Lee, K. K., Stewart, S., Ferry, A. V., Chapman, A. R., Marshall, L., Strachan, F. E., Cruickshank, A., Maguire, D., Berry, C., Findlay, I., Shah, A. S. V., Newby, D. E., Mills, N. L. & Anand, A., 5 Nov 2019, In: Circulation. 140, 19, p. 1557–1568

Research output: Contribution to journal › Article › peer-review

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Guiding Therapy by Coronary CT Angiography Improves Outcomes in Patients With Stable Chest Pain

SCOT-HEART Investigators, 22 Oct 2019, In: Journal of the American College of Cardiology. 74, 16, p. 2058-2070 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome

High-STEACS Investigators, Lee, K. K., Ferry, A. V., Anand, A., Strachan, F. E., Chapman, A. R., Kimenai, D. M., Meex, S. J. R., Berry, C., Findlay, I., Reid, A., Cruickshank, A., Gray, A., Collinson, P. O., Apple, F. S., McAllister, D. A., Maguire, D., Fox, K. A. A., Newby, D. E., Tuck, C., & 4 othersKeerie, C., Weir, C. J., Shah, A. S. V. & Mills, N. L., 22 Oct 2019, In: Journal of the American College of Cardiology. 74, 16, p. 2032-2043 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Global burden of atherosclerotic cardiovascular disease in people with hepatitis C virus infection: a systematic review, meta-analysis, and modelling study

Lee, K. K., Stelzle, D., Bing, R., Anwar, M., Strachan, F., Bashir, S., Newby, D. E., Shah, J. S., Chung, M. H., Bloomfield, G. S., Longenecker, C. T., Bagchi, S., Kottilil, S., Blach, S., Razavi, H., Mills, P. R., Mills, N. L., McAllister, D. A. & Shah, A. S. V., 1 Oct 2019, In: The Lancet Gastroenterology & Hepatology. 4, 10, p. 794-804

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A Proposal for Modest Revision of the Definition of Type 1 and Type 2 Myocardial Infarction

de Lemos, J. A., Newby, L. K. & Mills, N., 6 Sept 2019, In: Circulation.

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Assessment and Treatment of Patients with Type 2 Myocardial Infarction and Acute Non-Ischemic Myocardial Injury

DeFilippis, A. P., Chapman, A. R., Mills, N. L., de Lemos, J. A., Arbab-Zadeh, A., Newby, L. K. & Morrow, D. A., 16 Aug 2019, (E-pub ahead of print) In: Circulation. 140, 20, p. 1661–1678

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Endothelin Receptor Antagonism Improves Lipid Profiles and Lowers PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) in Patients With Chronic Kidney Disease

Farrah, T. E., Anand, A., Gallacher, P. J., Kimmitt, R., Carter, E., Dear, J. W., Mills, N. L., Webb, D. J. & Dhaun, N., Aug 2019, In: Hypertension. 74, 2, p. 323-330 8 p.

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Convalescent troponin and cardiovascular death following acute coronary syndrome

Adamson, P. D., Mcallister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., Ellis, C., Mills, N. L., Newby, D. E., Pemberton, C., Troughton, R. W., Doughty, R. N. & Richards, A. M., 23 Jul 2019, In: Heart.

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Endothelin receptor antagonism improves lipid profiles & lowers PCSK9 in patients with chronic kidney disease

Farrah, T., Anand, A., Gallacher, P., Kimmitt, R. A., Carter, E., Dear, J., Mills, N., Webb, D. & Dhaun, N., 10 Jun 2019, In: Hypertension.

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Clinical determinants of plasma cardiac biomarkers in patients with stable chest pain

Bing, R., Henderson, J., Hunter, A. L., Williams, M., Moss, A., Shah, A. S., McAllister, D., Dweck, M., Newby, D., Mills, N. & Adamson, P., 1 Jun 2019, In: Heart.

Research output: Contribution to journal › Article › peer-review

Open Access

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Heart Failure and Healthcare Informatics

Anwar, M., Japp, A. & Mills, N., 21 May 2019, In: PLoS Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cardiac Troponin to Guide the Use of Noninvasive Testing in Patients Ruled Out for Myocardial Infarction

Mills, N. L. & Omland, T., 1 Apr 2019, In: Circulation. 139, 14, p. 1655-1657

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Global Adoption of High-Sensitivity Cardiac Troponins and the Universal Definition of Myocardial Infarction

Anand, A., Shah, A. S. V., Beshiri, A., Jaffe, A. S. & Mills, N. L., 9 Jan 2019, (E-pub ahead of print) In: Clinical Chemistry.

Research output: Contribution to journal › Article › peer-review

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2018

Novel high-sensitivity cardiac troponin I assay in patients with suspected acute coronary syndrome

Chapman, A., Fujisawa, T., Lee, K. K., Andrews, J., Anand, A., Sandeman, D., Ferry, A. V., Stewart, S., Marshall, L., Strachan, F., Gray, A., Newby, D., Shah, A. & Mills, N., 15 Nov 2018, In: Heart.

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Open Access

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Prevalence, determinants and clinical associations of high-sensitivity cardiac troponin in patients attending the Emergency Department

Lee, K., Noaman, A., Vaswani, A., Gibbins, M., Griffiths, M. E., Chapman, A., Strachan, F., Anand, A., McAllister, D., Newby, D., Gray, A., Mills, N. & Shah, A., 25 Oct 2018, In: American Journal of Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

High-Sensitivity Cardiac Troponin I and Clinical Risk Scores in Patients With Suspected Acute Coronary Syndrome

Chapman, A. R., Hesse, K., Andrews, J., Ken Lee, K., Anand, A., Shah, A. S. V., Sandeman, D., Ferry, A. V., Jameson, J., Piya, S., Stewart, S., Marshall, L., Strachan, F. E., Gray, A., Newby, D. E. & Mills, N. L., 16 Oct 2018, In: Circulation. 138, 16, p. 1654-1665

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High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial

Shah, A. S. V., Anand, A., Strachan, F. E., Ferry, A. V., Lee, K. K., Chapman, A. R., Sandeman, D., Stables, C. L., Adamson, P. D., Andrews, J. P. M., Anwar, M. S., Hung, J., Moss, A. J., O'Brien, R., Berry, C., Findlay, I., Walker, S., Cruickshank, A., Reid, A., Gray, A., & 37 othersCollinson, P. O., Apple, F. S., McAllister, D. A., Maguire, D., Fox, K. A. A., Newby, D. E., Tuck, C., Harkess, R., Parker, R. A., Keerie, C., Weir, C. J., Mills, N. L., High-STEACS Investigators, Marshall, L., Stewart, S. D., Fujisawa, T., Vallejos, C. A., Tsanas, A., Hautvast, M., McPherson, J., McKinlay, L., Malo, J., Fischbacher, C. M., Croal, B. L., Leslie, S. J., Walker, A., Wackett, T., Armstrong, R., Stirling, L., MacDonald, C., Sadat, I., Finlay, F., Charles, H., Linksted, P., Young, S., Alexander, B. & Duncan, C., 15 Sept 2018, In: The Lancet. 392, 10151, p. 919-928 10 p.

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Cardiac Troponin I and Cardiovascular Risk in Patients With Chronic Obstructive Pulmonary Disease

Adamson, P. D., Anderson, J. A., Brook, R. D., Calverley, P. M. A., Celli, B. R., Cowans, N. J., Crim, C., Dixon, I. J., Martinez, F. J., Newby, D. E., Vestbo, J., Yates, J. C. & Mills, N. L., 4 Sept 2018, In: Journal of the American College of Cardiology. 72, 10, p. 1126-1137 12 p.

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Comparison Between High Sensitivity Cardiac Troponin T and Cardiac Troponin I in a Large General Population Cohort

Welsh, P., Preiss, D., Shah, A., McAllister, D., Briggs, A. H., Boachie, C., McConnachie, A., Hayward, C., Padmanabhan, S., Welsh, C., Woodward, M., Campbell, A., Porteous, D., Mills, N. & Sattar, N., 20 Aug 2018, In: Clinical Chemistry. 64, 11, 10 p.

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High-Sensitivity Cardiac Troponin I and the Diagnosis of Coronary Artery Disease in Patients With Suspected Angina Pectoris

Adamson, P. D., Hunter, A., Madsen, D. M., Shah, A. S. V., McAllister, D. A., Pawade, T. A., Williams, M. C., Berry, C., Boon, N. A., Flather, M., Forbes, J., McLean, S., Roditi, G., Timmis, A. D., van Beek, E. J. R., Dweck, M. R., Mickley, H., Mills, N. L. & Newby, D. E., 14 Feb 2018, In: Circulation: Cardiovascular Quality and Outcomes. 11, 2, p. e004227

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2017

Myocardial inflammation, injury and infarction during on-pump coronary artery bypass graft surgery

Alam, S. R., Stirrat, C., Spath, N., Zamvar, V., Pessotto, R., Dweck, M. R., Moore, C., Semple, S., El-Medany, A., Manoharan, D., Mills, N. L., Shah, A., Mirsadraee, S., Newby, D. E. & Henriksen, P. A., 16 Dec 2017, In: Journal of cardiothoracic surgery. 12, 10 p., 115.

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Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome

Chapman, A. R., Lee, K. K., McAllister, D. A., Cullen, L., Greenslade, J. H., Parsonage, W., Worster, A., Kavsak, P. A., Blankenberg, S., Neumann, J., Söerensen, N. A., Westermann, D., Buijs, M. M., Verdel, G. J. E., Pickering, J. W., Than, M. P., Twerenbold, R., Badertscher, P., Sabti, Z., Mueller, C., & 17 othersAnand, A., Adamson, P., Strachan, F. E., Ferry, A., Sandeman, D., Gray, A., Body, R., Keevil, B., Carlton, E., Greaves, K., Korley, F. K., Metkus, T. S., Sandoval, Y., Apple, F. S., Newby, D. E., Shah, A. S. V. & Mills, N. L., 21 Nov 2017, In: Journal of the American Medical Association. 318, 19, p. 1913-1924 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial infarction: prospective cohort study

Shah, A. S. V., Sandoval, Y., Noaman, A., Sexter, A., Vaswani, A., Smith, S. W., Gibbins, M., Griffiths, M., Chapman, A. R., Strachan, F. E., Anand, A., Denvir, M. A., Adamson, P. D., D'Souza, M. S., Gray, A. J., McAllister, D. A., Newby, D. E., Apple, F. S. & Mills, N. L., 7 Nov 2017, In: British Medical Journal (BMJ). 359, 8130, 10 p., 4788.

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Endothelial Progenitor Cell Biology and Vascular Recovery Following Transradial Cardiac Catheterization

Mitchell, A., Fujisawa, T., Mills, N. L., Brittan, M., Newby, D. E. & Cruden, N. L. M., 28 Oct 2017, In: Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease. 6, 11

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Inhaled Nanoparticles Accumulate at Sites of Vascular Disease

Miller, M. R., Raftis, J. B., Langrish, J. P., Mclean, S. G., Samutrtai, P., Connell, S. P., Wilson, S., Vesey, A. T., Fokkens, P. H. B., Boere, A. J. F., Krystek, P., Campbell, C. J., Hadoke, P. W. F., Donaldson, K., Cassee, F. R., Newby, D. E., Duffin, R. & Mills, N. L., 23 May 2017, In: ACS Nano. 11, 5, p. 4542-4552 11 p.

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Comparison of the Efficacy and Safety of Early Rule Out Pathways for Acute Myocardial Infarction

Chapman, A. R., Anand, A., Boeddinghaus, J., Ferry, A. V., Sandeman, D., Adamson, P. D., Andrews, J., Tan, S., Cheng, S. F., D'Souza, M., Orme, K., Strachan, F. E., Nestelberger, T., Twerenbold, R., Badertscher, P., Reichlin, T., Gray, A., Shah, A. S. V., Mueller, C., Newby, D. E., & 1 othersMills, N. L., 25 Apr 2017, In: Circulation. 135, 17, p. 1586-1596 11 p.

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2016

High-Sensitivity Cardiac Troponin, Statin Therapy, and Risk of Coronary Heart Disease

Ford, I., Shah, A. S. V., Zhang, R., Mcallister, D. A., Strachan, F. E., Caslake, M., Newby, D. E., Packard, C. J. & Mills, N. L., 27 Dec 2016, In: Journal of the American College of Cardiology. 68, 25, p. 2719-2728

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High-Sensitivity Cardiac Troponin and Coronary Heart Disease

Research output

Search results