Imaging perfusion deficits and thrombolysis safety and efficacy in acute ischaemic stroke. The Third International Stroke Trial (IST-3)

Research output

Research output per year 2012 2012 2013 2015 2019

• 20 Article
• 11 Other
• 3 Abstract
• 2 Literature review

Research output per year

Research output per year

Search results

• 2019

  Observer Agreement on Computed Tomography Perfusion Imaging in Acute Ischemic Stroke

  El-tawil, S., Mair, G., Huang, X., Sakka, E., Palmer, J., Ford, I., Kalra, L., Wardlaw, J. & Muir, K. W., 25 Sept 2019, In: Stroke.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Visual rating scales of white matter hyperintensities and atrophy: comparison of computed tomography and magnetic resonance imaging

  Ferguson, K., Cvoro, V., Maclullich, A., Shenkin, S., Sandercock, P., Sakka, E. & Wardlaw, J., 23 Mar 2018, (E-pub ahead of print) In: Journal of Stroke & Cerebrovascular Diseases.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Rating Scale 100%
  • White Matter 100%
  • Computer Assisted Tomography 100%
  • Magnetic Resonance Imaging 100%
  • Atrophy 100%

• Coupled changes in hippocampal structure and cognitive ability in later life

  Anblagan, D., Valdes Hernandez, M., Ritchie, S. J., Aribisala, B., Royle, N., Hamilton, I., Cox, S., Gow, A., Pattie, A., Corley, J., Starr, J., Muñoz Maniega, S., Bastin, M., Deary, I. & Wardlaw, J., 4 Jan 2018, (E-pub ahead of print) In: Brain and Behavior.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Domains 71%
  • Fractional Anisotropy 57%
  • Verbal Memory 28%
  • Working Memory 28%
• 2017

  Brain Lesion Segmentation through Image Synthesis and Outlier Detection

  Bowles, C., Qin, C., Guerrero, R., Gunn, R., Hammers, A., Dickie, D. A., Valdes Hernandez, M., Wardlaw, J. & Rueckert, D., 2017, In: NeuroImage: Clinical. 16, p. 643-658

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pathology 100%
  • Outlier 100%
  • Segmentation 100%
  • Lesion Segmentation 100%
  • Image Synthesis 100%
• 2015

  Effect of X-Ray Attenuation of Arterial Obstructions on Intravenous Thrombolysis and Outcome after Ischemic Stroke

  IST-3 Collaborative Group, Mair, G., von Kummer, R., Lindley, R., Sandercock, P. & Wardlaw, J., 23 Dec 2015, In: PLoS ONE. 10, e0145683.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Blood Clot Lysis 100%
  • Obstruction 100%
  • Brain Ischemia 100%
  • X-Ray 100%
  • Ischemic Stroke 100%

• Effects of blood pressure and blood pressure-lowering treatment during the first 24 hours among patients in the Third International Stroke Trial of thrombolytic treatment for acute ischemic stroke

  Berge, E., Cohen, G., Lindley, R., Sandercock, P., Wardlaw, J., Sandset, E. C. & Whiteley, W., 20 Oct 2015, In: Stroke. 46, 12, p. 3362-3369 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Blood Pressure 100%
  • Therapeutic Procedure 100%
  • Thrombolytic Drug 100%
  • Apoplexy 100%
  • Patient 100%

• Protocol for the perfusion and angiography imaging sub-study of the Third International Stroke Trial (IST-3) of alteplase treatment within six-hours of acute ischemic stroke

  Wardlaw, J. M., von Kummer, R., Carpenter, T., Parsons, M., Lindley, R. I., Cohen, G., Murray, V., Kobayashi, A., Peeters, A., Chappell, F. & Sandercock, P. A. G., Aug 2015, In: International Journal of Stroke. 10, 6, p. 956-968

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Angiography 100%
  • Therapeutic Procedure 100%
  • Alteplase 100%
  • Apoplexy 100%
  • Brain Ischemia 100%

• Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial

  The IST-3 Collaborative Group , 1 May 2015, In: Lancet Neurology. 14, 5, p. 485-496 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Analysis 100%
  • Association 100%
  • Randomized Controlled Trial 100%
  • Brain Imaging 100%
  • Alteplase 100%

• Alteplase for Acute Ischemic Stroke: Outcomes by Clinically Important Subgroups in the Third International Stroke Trial

  Lindley, R. I., Wardlaw, J. M., Whiteley, W. N., Cohen, G., Blackwell, L., Murray, G. D., Sandercock, P. A. G., on behalf of the IST-3 Collaborative Group, Sellar, R. & Farrall, A., Mar 2015, In: Stroke. 46, 3, p. 746-756 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Alteplase 100%
  • Apoplexy 100%
  • Brain Ischemia 100%
  • Stroke 100%
  • Ischemic Stroke 100%

• Observer reliability of CT angiography in the assessment of acute ischaemic stroke: data from the Third International Stroke Trial

  The IST-3 Collaborative Group , Jan 2015, In: Neuroradiology. 57, 1, p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Assessment 100%
  • Computed Tomography Angiography 100%
  • Apoplexy 100%
  • Brain Ischemia 100%
  • Angiography 100%

• Sensitivity and specificity of the Hyperdense Artery Sign for arterial obstruction in acute ischemic stroke

  IST-3 Collaborative Group, Mair, G., Boyd, E., Chappell, F., von Kummer, R., Lindley, R., Sandercock, P. & Wardlaw, J., Jan 2015, In: Stroke. 46, 1, p. 102-107 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sensitivity and Specificity 100%
  • Artery 100%
  • Obstruction 100%
  • Brain Ischemia 100%
  • Accuracy 36%
• 2014

  Imaging of acute stroke prior to treatment: current practice and evolving techniques

  Mair, G. & Wardlaw, J., Aug 2014, In: British Journal of Radiology. 87, 1040, 14 p., 20140216.

  Research output: Contribution to journal › Literature review › peer-review

  • Therapeutic Procedure 100%
  • Apoplexy 100%
  • Blood Clot Lysis 40%
  • Magnetic Resonance Angiography 20%
  • Scintigraphy 20%

• Imaging perfusion deficits, arterial patency and thrombolysis safety and efficacy in acute ischaemic stroke. An observational study of the effect of advanced imaging methods in The Third International Stroke Trial (IST-3), a randomised controlled trial

  Wardlaw, J., Carpenter, T., Sakka, E., Mair, G., Cohen, G., Shuler, K., Palmer, J. & Sandercock, P., 2014, In: Efficacy and Mechanism Evaluation. 1, p. 1-116

  Research output: Contribution to journal › Literature review › peer-review

• Location, extent and persistence of hyperdense arteries affects outcome in acute ischemic stroke

  Mair, G., von Kummer, R., Morris, Z., von Heijne, A., Bradey, N., Cala, L., Peeters, A., Farrall, A., Adami, A., Potter, G., Cohen, G., Sandercock, P., Lindley, R. & Wardlaw, J., 2014, In: Circulation.

  Research output: Contribution to journal › Article › peer-review

• 2013

  Acute Stroke Imaging Research Roadmap II

  Storke Imageing Res STIR Imaging, Virtual Int Stroke Trials Archive, Wintermark, M., Albers, G. W., Broderick, J. P., Demchuk, A. M., Fiebach, J. B., Fiehler, J., Grotta, J. C., Houser, G., Jovin, T. G., Lees, K. R., Lev, M. H., Liebeskind, D. S., Luby, M., Muir, K. W., Parsons, M. W., von Kummer, R., Wardlaw, J. M., Wu, O., & 32 othersYoo, A. J., Alexandrov, A. V., Alger, J. R., Aviv, R. I., Bammer, R., Baron, J-C., Calamante, F., Campbell, B. C. V., Carpenter, T., Christensen, S., Copen, W. A., Derdeyn, C. P., Haley, C., Khatri, P., Kudo, K., Lansberg, M. G., Latour, L. L., Lee, T-Y., Leigh, R., Lin, W., Lyden, P., Mair, G., Menon, B. K., Michel, P., Mikulik, R., Nogueira, R. G., Ostergaard, L., Pedraza, S., Riedel, C. H., Rowley, H. A., Sanelli, P. C. & Sasaki, M., Sept 2013, In: Stroke. 44, 9, p. 2628-2639 12 p.

  Research output: Contribution to journal › Article › peer-review

• Lesion Area Detection Using Source Image Correlation Coefficient for CT Perfusion Imaging

  Zhu, F., Rodriguez Gonzalez, D., Carpenter, T., Atkinson, M. & Wardlaw, J., Sept 2013, In: IEEE Journal of Biomedical and Health Informatics. 17, 5, p. 950-958 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Scintigraphy 100%
  • Lesion 100%
  • Computer Assisted Tomography 100%
  • Correlation Coefficient 100%
  • Perfusion 100%

• Recommendations on angiographic revascularization grading standards for acute ischemic stroke: A consensus statement

  Cerebral Angiographic Revascularization Grading (CARG) Collaborators, Zaidat, O. O., Yoo, A. J., Khatri, P., Tomsick, T. A., von Kummer, R., Saver, J. L., Marks, M. P., Prabhakaran, S., Kallmes, D. F., Fitzsimmons, B-F. M., Mocco, J., Wardlaw, J. M., Barnwell, S. L., Jovin, T. G., Linfante, I., Siddiqui, A. H., Alexander, M. J., Hirsch, J. A., Wintermark, M., & 16 othersAlbers, G., Woo, H. H., Heck, D. V., Lev, M., Aviv, R., Hacke, W., Warach, S., Broderick, J., Derdeyn, C. P., Furlan, A., Nogueira, R. G., Yavagal, D. R., Goyal, M., Demchuk, A. M., Bendszus, M. & Liebeskind, D. S., Sept 2013, In: Stroke; a journal of cerebral circulation. 44, 9, p. 2650-63 14 p.

  Research output: Contribution to journal › Article › peer-review

• Association of non-contrast CT and CT angiography with baseline clinical deficit and functional outcome. Substudy analysis of imaging from the Third International Stroke Trial (IST- 3)

  Mair, G., 2013, (Unpublished).

  Research output: Contribution to conference › Abstract

• Combining CT angiography with non-contrast CT to predict infarct on follow up CT in acute ischaemic stroke. Substudy analysis of imaging from the Third International Stroke Trial (IST-3)

  Mair, G., 2013, (Unpublished).

  Research output: Contribution to conference › Abstract

• Does perfusion imaging lesion size or mismatch influence six month outcomes after rt-PA given up to six hours after acute ischaemic stroke? The Third International Stroke Trial (IST-3)

  Wardlaw, J., 2013, (Unpublished).

  Research output: Contribution to conference › Other

• Perfusion Imaging In Patients Randomised To rt-PA or Control In The Third International Stroke Trial (IST-3): Baseline Characteristics And Association With Outcome

  Wardlaw, J., 2013, (Unpublished).

  Research output: Contribution to conference › Other

• Response to intravenous rt-PA in ischaemic stroke patients with and without arterial occlusion on CTA: The Third Interventional Stroke Trial (IST-3)

  Mair, G., 2013, (Unpublished).

  Research output: Contribution to conference › Abstract

• Update on structural and advanced imaging in patient selection for intravenous thrombolysis

  Wardlaw, J., 2013, (Unpublished).

  Research output: Contribution to conference › Other

• 2012

  Parallel perfusion imaging processing using GPGPU

  Zhu, F., Gonzalez, D. R., Carpenter, T., Atkinson, M. & Wardlaw, J., Dec 2012, In: Computer methods and programs in biomedicine. 108, 3, p. 1012-1021 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Processing 100%
  • Scintigraphy 100%
  • Graphics Processor 100%
  • Brain 100%
  • Brain Perfusion 66%

• Computed tomography perfusion imaging denoising using Gaussian process regression

  Zhu, F., Carpenter, T., Gonzalez, D. R., Atkinson, M. & Wardlaw, J., 21 Jun 2012, In: Physics in Medicine & Biology. 57, 12, p. N183-N198 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Computer Assisted Tomography 100%
  • Scintigraphy 100%
  • Gaussian Process 100%
  • Regression 100%
  • Computed Tomography 100%

• The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

  Sandercock, P., Wardlaw, J. M., Lindley, R. I., Dennis, M., Cohen, G., Murray, G., Innes, K., Venables, G., Czlonkowska, A., Kobayashi, A., Ricci, S., Murray, V., Berge, E., Slot, K. B., Hankey, G. J., Correia, M., Peeters, A., Matz, K., Lyrer, P., Gubitz, G., & 5 othersPhillips, S. J., Arauz, A., IST-3 collaborative group, Al-Shahi Salman, R. & Lewis, S., Jun 2012, In: The Lancet. 379, 9834, p. 2352-2363 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Randomized Controlled Trial 100%
  • Alteplase 100%
  • Stroke 100%
  • Ischemic Stroke 100%
  • Brain Ischemia 100%

• Medical image analysis methods in MR/CT-imaged acute-subacute ischemic stroke lesion: Segmentation, prediction and insights into dynamic evolution simulation models. A critical appraisal

  Rekik, I., Carpenter, T. K., Wardlaw, J. M. & Allassonnière, S., 1 Jan 2012, In: NeuroImage: Clinical. 1, 1, p. 164-178 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lesion 100%
  • Computer Assisted Tomography 100%
  • Critical Appraisal 100%
  • Image Analysis (Medical Imaging) 100%
  • Brain Ischemia 100%

• Affordable evidence-based imaging assessment in acute stroke

  Wardlaw, J., 2012, (Unpublished).

  Research output: Contribution to conference › Other

• Essential new information about the imaging contribution to the management of stroke

  Wardlaw, J., 2012, (Unpublished).

  Research output: Contribution to conference › Other

• Getting the best out of your radiology department

  Wardlaw, J., 2012, (Unpublished).

  Research output: Contribution to conference › Other

• Interpretation of the hyper-acute CT in stroke and how the imaging steps fit together in different locations

  Wardlaw, J., 2012, (Unpublished).

  Research output: Contribution to conference › Other

• New insights into the brain and vascular disease from imaging: why it's not just enough to be a radiologist

  Wardlaw, J., 2012, (Unpublished).

  Research output: Contribution to conference › Other

• State of the ART 2: Ischaemic Stroke

  Wardlaw, J., 2012, (Unpublished).

  Research output: Contribution to conference › Other

• Statistical analysis plan for the third International Stroke Trial (IST-3); part of a 'thread' of reports of the trial

  ST-3 collaborative group, Sandercock, P., Lindley, R., Wardlaw, J., Whiteley, W. & Murray, G., 2012, In: International Journal of Stroke. 7, 3, p. 186-7 2 p.

  Research output: Contribution to journal › Article › peer-review

• The Third International Stroke Trial (IST-3) of thrombolysis Main results II: effects of iv thrombolysis. IST-3 in context of an updated meta-analysis of the randomised trials

  Wardlaw, J., 2012, (Unpublished).

  Research output: Contribution to conference › Other

• Which parameters predict who will have symptomatic intracranial bleeding or massive cerebral oedema?

  Wardlaw, J., 2012, (Unpublished).

  Research output: Contribution to conference › Other