Induction of neutrophil apoptosis and treatment of severe lung inflammation

2022

Inhibition of cyclin-dependent kinase 9 downregulates cytokine production without detrimentally affecting human monocyte-derived macrophage viability

McHugh, B., Stephen, J., Robb, C., Fox, S., Kipari, T., Cartwright, J., Haslett, C., Duffin, R., Lucas, C. D. & Rossi, A. G., 26 May 2022, In: Frontiers in Cell and Developmental Biology. 10, 905315.

Research output: Contribution to journal › Article › peer-review

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2016

11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice

Coutinho, A. E., Kipari, T. M. J., Zhang, Z., Esteves, C. L., Lucas, C. D., Gilmour, J. S., Webster, S. P., Walker, B. R., Hughes, J., Savill, J. S., Seckl, J. R., Rossi, A. G. & Chapman, K. E., 4 May 2016, (E-pub ahead of print) In: Endocrinology. 157, 7, p. 2928-2936 9 p.

Research output: Contribution to journal › Article › peer-review

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2015

Crosstalk between monocytes and myometrial smooth muscle in culture generates synergistic pro-inflammatory cytokine production and enhances myocyte contraction, with effects opposed by progesterone

Rajagopal, S. P., Hutchinson, J. L., Dorward, D., Rossi, A. G. & Norman, J. E., 22 May 2015, In: Molecular Human Reproduction.

Research output: Contribution to journal › Article › peer-review

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2014

Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon

Robb, C. T., Dyrynda, E. A., Gray, R. D., Rossi, A. G. & Smith, V. J., 13 Aug 2014, In: Nature Communications. 5, 11 p., 4627.

Research output: Contribution to journal › Article › peer-review

Open Access

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Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

Lucas, C. D., Dorward, D. A., Tait, M. A., Fox, S., Marwick, J. A., Allen, K. C., Robb, C. T., Hirani, N., Haslett, C., Duffin, R. & Rossi, A. G., Jul 2014, In: Mucosal Immunology. 7, 4, p. 857-868 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Apoptotic cell clearance: basic biology and therapeutic potential

Poon, I. K. H., Lucas, C. D., Rossi, A. G. & Ravichandran, K. S., Mar 2014, In: Nature Reviews Immunology. 14, 3, p. 166-180 15 p.

Research output: Contribution to journal › Literature review › peer-review

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Assessment of neutrophil apoptosis

Dorward, D. A., Rossi, A. G., Dransfield, I. & Lucas, C. D., 2014, Neutrophil Methods and Protocols. Quin, MT. & Deleo, FR. (eds.). 2nd ed. Totowa: Humana Press, Vol. 1124. p. 159-80 22 p. (Methods in Molecular Biology; vol. 1124).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2013

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

Marwick, J. A., Dorward, D. A., Lucas, C. D., Jones, K. O., Sheldrake, T. A., Fox, S., Ward, C., Murray, J., Brittan, M., Hirani, N., Duffin, R., Dransfield, I., Haslett, C. & Rossi, A. G., 20 Aug 2013, In: Journal of Leukocyte Biology. 94, 6, p. 1285-1292

Research output: Contribution to journal › Article › peer-review

Open Access

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Resolution of inflammation: Mechanisms and opportunity for drug development

Alessandri, A. L., Sousa, L. P., Lucas, C. D., Rossi, A. G., Pinho, V. & Teixeira, M. M., Aug 2013, In: Pharmacology and Therapeutics. 139, 2, p. 189-212 24 p.

Research output: Contribution to journal › Literature review › peer-review

Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production

Dorward, D. A., Lucas, C. D., Alessandri, A. L., Marwick, J. A., Rossi, F., Dransfield, I., Haslett, C., Dhaliwal, K. & Rossi, A. G., Jul 2013, In: Journal of Leukocyte Biology. 94, 1, p. 193-202 10 p.

Research output: Contribution to journal › Article › peer-review

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Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

Montanaro, G., Bertinaria, M., Rolando, B., Fruttero, R., Lucas, C., Dorward, D. A., Rossi, A. G., Megson, I. L. & Gasco, A., 1 Apr 2013, In: Bioorganic and Medicinal Chemistry. 21, 7, p. 2107-2116 10 p.

Research output: Contribution to journal › Article › peer-review

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Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

Gray, R. D., Lucas, C., Mackellar, A., Li, F., Hiersemenzel, K., Haslett, C., Davidson, D. J. & Rossi, A. G., 21 Mar 2013, In: Journal of inflammation. 10, 1, 8 p., 12.

Research output: Contribution to journal › Article › peer-review

Open Access

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Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

Lucas, C., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R. & Rossi, A. G., Mar 2013, In: The FASEB Journal. 27, 3, p. 1084-1094 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The involvement of xanthohumol in the expression of annexin in human malignant glioblastoma cells

Festa, M., Caputo, M., Cipolla, C., D'Acunto, C., Rossi, A., Tecce, M. & Capasso, A., 2013, In: The Open Biochemistry Journal. 7, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

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2012

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

Leitch, A. E., Lucas, C., Marwick, J. A., Duffin, R., Haslett, C. & Rossi, A. G., Dec 2012, In: Cell Death & Differentiation (CDD). 19, 12, p. 1950-1961 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury

Dhaliwal, K., Scholefield, E., Ferenbach, D., Gibbons, M., Duffin, R., Dorward, D. A., Morris, A. C., Humphries, D., Mackinnon, A., Wilkinson, T. S., Wallace, W., van Rooijen, N., Mack, M., Rossi, A. G., Davidson, D. J., Hirani, N., Hughes, J., Haslett, C. & Simpson, A. J., 15 Sept 2012, In: American Journal of Respiratory and Critical Care Medicine. 186, 6, p. 514-524 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Imaging inflammation: Molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution

Dorward, D. A., Lucas, C., Rossi, A. G., Haslett, C. & Dhaliwal, K., Aug 2012, In: Pharmacology and Therapeutics. 135, 2, p. 182-199 18 p.

Research output: Contribution to journal › Literature review › peer-review

Peritonitis Activates Transcription of the Human Prolactin Locus in Myeloid Cells in a Humanized Transgenic Rat Model

Semprini, S., McNamara, A. V., Awais, R., Featherstone, K., Harper, C. V., McNeilly, J. R., Patist, A., Rossi, A. G., Dransfield, I., McNeilly, A. S., Davis, J. R. E., White, M. R. H. & Mullins, J. J., 1 Jun 2012, In: Endocrinology . 153, 6, p. 2724-2734

Research output: Contribution to journal › Article › peer-review

Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN

Hart, S. P., Rossi, A. G., Haslett, C. & Dransfield, I., 9 Mar 2012, In: PLoS ONE. 7, 3, p. e33142

Research output: Contribution to journal › Article › peer-review

Open Access

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A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation

Brittan, M., Barr, L., Conway Morris, A., Duffin, R., Rossi, F., Johnston, S., Monro, G., Anderson, N., Rossi, A. G., McAuley, D. F., Haslett, C., Hirani, N., Dhaliwal, K. & Simpson, A. J., 2012, In: European Respiratory Journal. 40, 1, p. 206-214 9 p.

Research output: Contribution to journal › Article › peer-review

2011

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

Alessandri, A. L., Duffin, R., Leitch, A. E., Lucas, C., Sheldrake, T. A., Dorward, D. A., Hirani, N., Pinho, V., de Sousa, L. P., Teixeira, M. M., Lyons, J. F., Haslett, C. & Rossi, A. G., 30 Sept 2011, In: PLoS ONE. 6, 9, p. - 10 p., e25683.

Research output: Contribution to journal › Article › peer-review

Open Access

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C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients

Morris, A. C., Brittan, M., Wilkinson, T. S., McAuley, D. F., Antonelli, J., McCulloch, C., Barr, L. C., McDonald, N. A., Dhaliwal, K., Jones, R., Mackellar, A., Haslett, C., Hay, A. W., Swann, D. G., Anderson, N., Laurenson, I. F., Davidson, D. J., Rossi, A. G., Walsh, T. S. & Simpson, A. J., 12 May 2011, In: Blood. 117, 19, p. 5178-5188 11 p.

Research output: Contribution to journal › Article › peer-review

Mechanisms of Resolution of Inflammation A Focus on Cardiovascular Disease

Maskrey, B. H., Megson, I. L., Whitfield, P. D. & Rossi, A. G., May 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 5, p. 1001-1006 6 p.

Research output: Contribution to journal › Article › peer-review

Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells

Shaw, C. A., Taylor, E. L., Fox, S., Megson, I. L. & Rossi, A. G., 1 Jan 2011, In: Free Radical Biology and Medicine. 50, 1, p. 93-101 9 p.

Research output: Contribution to journal › Article › peer-review

5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

Yang, CHENYING., Nixon, M., Kenyon, C. J., Livingstone, D. E. W., Duffin, R., Rossi, A. G., Walker, B. R. & Andrew, R., 2011, In: British Journal of Pharmacology. 164, 6, p. 1661-71 11 p.

Research output: Contribution to journal › Article › peer-review

Anti-inflammatory mediators as physiological and pharmacological regulators of parturition

Rinaldi, S., Hutchinson, J. L., Rossi, A. G. & Norman, J. E., 2011, In: Expert Review of Clinical Immunology. 7, 5, p. 675-96 22 p.

Research output: Contribution to journal › Literature review › peer-review

Editorial: Neutrophil apoptosis: hot on the TRAIL of inflammatory resolution

Leitch, A. E., Lucas, C. & Rossi, A. G., 2011, In: Journal of Leukocyte Biology. 90, 5, p. 841-3 3 p.

Research output: Contribution to journal › Editorial › peer-review

Leukocyte migratory responses to apoptosis: the attraction and the distraction

Gregory, C. D., Rossi, A. G., Bournazou, I., Zhang, L. & Willems, J. J. L. P., 2011, In: Cell Adhesion and Migration. 5, 4, p. 293-7 5 p.

Research output: Contribution to journal › Article › peer-review

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Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways

Festa, M., Capasso, A., D'Acunto, C. W., Masullo, M., Rossi, A. G., Pizza, C. & Piacente, S., 2011, In: Journal of natural products. 74, 12, p. 2505-13 9 p.

Research output: Contribution to journal › Article › peer-review

2010

PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner

Sousa, L. P., Lopes, F., Silva, D. M., Tavares, L. P., Vieira, A. T., Rezende, B. M., Carmo, A. F., Russo, R. C., Garcia, C. C., Bonjardim, C. A., Alessandri, A. L., Rossi, A. G., Pinho, V. & Teixeira, M. M., May 2010, In: Journal of Leukocyte Biology. 87, 5, p. 895-904 10 p.

Research output: Contribution to journal › Article › peer-review

NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy

Fox, S., Wilkinson, T. S., Wheatley, P. S., Xiao, B., Morris, R. E., Sutherland, A., Simpson, A. J., Barlow, P. G., Butler, A. R., Megson, I. L. & Rossi, A. G., Apr 2010, In: Acta Biomaterialia. 6, 4, p. 1515-1521 7 p.

Research output: Contribution to journal › Article › peer-review

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

Leitch, A. E., Riley, N. A., Sheldrake, T. A., Festa, M., Fox, S., Duffin, R., Haslett, C. & Rossi, A. G., Apr 2010, In: European Journal of Immunology. 40, 4, p. 1127-1138 12 p.

Research output: Contribution to journal › Article › peer-review

Inhibition of eosinophil migration by lactoferrin

Bournazou, I., Mackenzie, K. J., Duffin, R., Rossi, A. G. & Gregory, C. D., Feb 2010, In: Immunology & Cell Biology. 88, 2, p. 220-223 4 p.

Research output: Contribution to journal › Article › peer-review

Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease

Fox, S., Leitch, A. E., Duffin, R., Haslett, C. & Rossi, A. G., 2010, In: Journal of Innate Immunity. 2, 3, p. 216-227 12 p.

Research output: Contribution to journal › Literature review › peer-review

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2009

Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

Leitch, A. E., Haslett, C. & Rossi, A. G., Oct 2009, In: British Journal of Pharmacology. 158, 4, p. 1004-16 13 p.

Research output: Contribution to journal › Literature review › peer-review

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

Li, H-N., Barlow, P. G., Bylund, J., Mackellar, A., Bjorstad, A., Conlon, J., Hiemstra, P. S., Haslett, C., Gray, M., Simpson, A. J., Rossi, A. G. & Davidson, D. J., Oct 2009, In: Journal of Leukocyte Biology. 86, 4, p. 891-902 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-kappa B

Sousa, L. P., Carmo, A. F., Rezende, B. M., Lopes, F., Silva, D. M., Alessandri, A. L., Bonjardim, C. A., Rossi, A. G., Teixeira, M. M. & Pinho, V., 15 Aug 2009, In: Biochemical Pharmacology. 78, 4, p. 396-405 10 p.

Research output: Contribution to journal › Article › peer-review

C5a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients

Conway-Morris, A., Kefala, K., Wilkinson, T. S., Dhaliwal, K., Farrell, L., Walsh, T., Mackenzie, S. J., Reid, H., Davidson, D. J., Haslett, C., Rossi, A. G., Sallenave, J-M. & Simpson, A. J., 1 Jul 2009, In: American Journal of Respiratory and Critical Care Medicine. 180, 1, p. 19-28 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

Shaw, C. A., Webb, D. J., Rossi, A. G. & Megson, I. L., May 2009, In: Journal of inflammation. 6, 10 p., 14.

Research output: Contribution to journal › Article › peer-review

Open Access

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Enzyme-Independent NO Stores in Human Skin: Quantification and Influence of UV Radiation

Mowbray, M., McLintock, S., Weerakoon, R., Lomatschinsky, N., Jones, S., Rossi, A. G. & Weller, R. B., Apr 2009, In: Journal of Investigative Dermatology. 129, 4, p. 834-842 9 p.

Research output: Contribution to journal › Article › peer-review

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-alpha

Michlewska, S., Dransfield, I., Megson, I. L. & Rossi, A. G., Mar 2009, In: The FASEB Journal. 23, 3, p. 844-54 11 p.

Research output: Contribution to journal › Article › peer-review

Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies

Mackinnon, A. C., Tufail-hanif, U., Wheatley, M., Rossi, A. G., Haslett, C., Seckl, M. & Sethi, T., 1 Jan 2009, In: British Journal of Pharmacology. 156, 1, p. 36-47

Research output: Contribution to journal › Article › peer-review

Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin

Bournazou, I., Pound, J. D., Duffin, R., Bournazos, S., Melville, L. A., Brown, S. B., Rossi, A. G. & Gregory, C. D., Jan 2009, In: Journal of Clinical Investigation. 119, 1, p. 20-32 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Highlights of a workshop to discuss targeting inflammation in cystic fibrosis

Banner, K. H., De Jonge, H., Elborn, S., Growcott, E., Gulbins, E., Konstan, M., Moss, R., Poll, C., Randell, S. H., Rossi, A. G., Thomas, L. & Waltz, D., Jan 2009, In: Journal of Cystic Fibrosis. 8, 1, p. 1-8 8 p.

Research output: Contribution to journal › Literature review › peer-review

Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma

Wallace, A. E., Sales, K. J., Catalano, R. D., Anderson, R. A., Williams, A. R. W., Wilson, M. R., Schwarze, J., Wang, H., Rossi, A. G. & Jabbour, H. N., 2009, In: Cancer Research. 69, 14, p. 5726-33 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

Duffin, R., Leitch, A. E., Sheldrake, T. A., Hallett, J. M., Meyer, C., Fox, S., Alessandri, A. L., Martin, M. C., Brady, H. J., Teixeira, M. M., Dransfield, I., Haslett, C. & Rossi, A. G., 2009, In: FEBS Letters. 583, 15, p. 2540-6 7 p.

Research output: Contribution to journal › Article › peer-review

2008

"Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa"

Leitch, A. E., Duffin, R., Haslett, C. & Rossi, A. G., Sept 2008, In: Mucosal Immunology. 1, 5, p. 350-363 14 p.

Research output: Contribution to journal › Literature review › peer-review

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

Turnbull, C. M., Marcarino, P., Sheldrake, T. A., Lazzarato, L., Cena, C., Fruttero, R., Gasco, A., Fox, S., Megson, I. L. & Rossi, A. G., 31 Jul 2008, In: Journal of inflammation. 5, p. - 10 p., 12.

Research output: Contribution to journal › Article › peer-review

Open Access

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Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation

Hallett, J. M., Leitch, A. E., Riley, N. A., Duffin, R., Haslett, C. & Rossi, A. G., May 2008, In: Trends in Pharmacological Sciences. 29, 5, p. 250-7 8 p.

Research output: Contribution to journal › Article › peer-review

Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function

Farnworth, S., Henderson, N. C., MacKinnon, A. C., Atkinson, K. M., Wilkinson, T., Dhaliwal, K., Hayashi, K., Simpson, A. J., Rossi, A. G., Haslett, C. & Sethi, T., Feb 2008, In: The American Journal of Pathology. 172, 2, p. 395-405 11 p.

Research output: Contribution to journal › Article › peer-review

Induction of neutrophil apoptosis and treatment of severe lung inflammation

Research output

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