Induction of neutrophil apoptosis and treatment of severe lung inflammation

2022

Inhibition of cyclin-dependent kinase 9 downregulates cytokine production without detrimentally affecting human monocyte-derived macrophage viability

McHugh, B., Stephen, J., Robb, C., Fox, S., Kipari, T., Cartwright, J., Haslett, C., Duffin, R., Lucas, C. D. & Rossi, A. G., 26 May 2022, In: Frontiers in Cell and Developmental Biology. 10, 905315.

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2016

11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice

Coutinho, A. E., Kipari, T. M. J., Zhang, Z., Esteves, C. L., Lucas, C. D., Gilmour, J. S., Webster, S. P., Walker, B. R., Hughes, J., Savill, J. S., Seckl, J. R., Rossi, A. G. & Chapman, K. E., 4 May 2016, (E-pub ahead of print) In: Endocrinology. 157, 7, p. 2928-2936 9 p.

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2015

Crosstalk between monocytes and myometrial smooth muscle in culture generates synergistic pro-inflammatory cytokine production and enhances myocyte contraction, with effects opposed by progesterone

Rajagopal, S. P., Hutchinson, J. L., Dorward, D., Rossi, A. G. & Norman, J. E., 22 May 2015, In: Molecular Human Reproduction.

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2014

Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon

Robb, C. T., Dyrynda, E. A., Gray, R. D., Rossi, A. G. & Smith, V. J., 13 Aug 2014, In: Nature Communications. 5, 11 p., 4627.

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Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

Lucas, C. D., Dorward, D. A., Tait, M. A., Fox, S., Marwick, J. A., Allen, K. C., Robb, C. T., Hirani, N., Haslett, C., Duffin, R. & Rossi, A. G., Jul 2014, In: Mucosal Immunology. 7, 4, p. 857-868 12 p.

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2013

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

Marwick, J. A., Dorward, D. A., Lucas, C. D., Jones, K. O., Sheldrake, T. A., Fox, S., Ward, C., Murray, J., Brittan, M., Hirani, N., Duffin, R., Dransfield, I., Haslett, C. & Rossi, A. G., 20 Aug 2013, In: Journal of Leukocyte Biology. 94, 6, p. 1285-1292

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Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production

Dorward, D. A., Lucas, C. D., Alessandri, A. L., Marwick, J. A., Rossi, F., Dransfield, I., Haslett, C., Dhaliwal, K. & Rossi, A. G., Jul 2013, In: Journal of Leukocyte Biology. 94, 1, p. 193-202 10 p.

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Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

Montanaro, G., Bertinaria, M., Rolando, B., Fruttero, R., Lucas, C., Dorward, D. A., Rossi, A. G., Megson, I. L. & Gasco, A., 1 Apr 2013, In: Bioorganic and Medicinal Chemistry. 21, 7, p. 2107-2116 10 p.

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Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

Gray, R. D., Lucas, C., Mackellar, A., Li, F., Hiersemenzel, K., Haslett, C., Davidson, D. J. & Rossi, A. G., 21 Mar 2013, In: Journal of inflammation. 10, 1, 8 p., 12.

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Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

Lucas, C., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R. & Rossi, A. G., Mar 2013, In: The FASEB Journal. 27, 3, p. 1084-1094 11 p.

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The involvement of xanthohumol in the expression of annexin in human malignant glioblastoma cells

Festa, M., Caputo, M., Cipolla, C., D'Acunto, C., Rossi, A., Tecce, M. & Capasso, A., 2013, In: The Open Biochemistry Journal. 7, p. 1-10 10 p.

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2012

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

Leitch, A. E., Lucas, C., Marwick, J. A., Duffin, R., Haslett, C. & Rossi, A. G., Dec 2012, In: Cell Death & Differentiation (CDD). 19, 12, p. 1950-1961 12 p.

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Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury

Dhaliwal, K., Scholefield, E., Ferenbach, D., Gibbons, M., Duffin, R., Dorward, D. A., Morris, A. C., Humphries, D., Mackinnon, A., Wilkinson, T. S., Wallace, W., van Rooijen, N., Mack, M., Rossi, A. G., Davidson, D. J., Hirani, N., Hughes, J., Haslett, C. & Simpson, A. J., 15 Sept 2012, In: American Journal of Respiratory and Critical Care Medicine. 186, 6, p. 514-524 11 p.

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Peritonitis Activates Transcription of the Human Prolactin Locus in Myeloid Cells in a Humanized Transgenic Rat Model

Semprini, S., McNamara, A. V., Awais, R., Featherstone, K., Harper, C. V., McNeilly, J. R., Patist, A., Rossi, A. G., Dransfield, I., McNeilly, A. S., Davis, J. R. E., White, M. R. H. & Mullins, J. J., 1 Jun 2012, In: Endocrinology . 153, 6, p. 2724-2734

Research output: Contribution to journal › Article › peer-review

Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN

Hart, S. P., Rossi, A. G., Haslett, C. & Dransfield, I., 9 Mar 2012, In: PLoS ONE. 7, 3, p. e33142

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A novel subpopulation of monocyte-like cells in the human lung after LPS inhalation

Brittan, M., Barr, L., Conway Morris, A., Duffin, R., Rossi, F., Johnston, S., Monro, G., Anderson, N., Rossi, A. G., McAuley, D. F., Haslett, C., Hirani, N., Dhaliwal, K. & Simpson, A. J., 2012, In: European Respiratory Journal. 40, 1, p. 206-214 9 p.

Research output: Contribution to journal › Article › peer-review

2011

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

Alessandri, A. L., Duffin, R., Leitch, A. E., Lucas, C., Sheldrake, T. A., Dorward, D. A., Hirani, N., Pinho, V., de Sousa, L. P., Teixeira, M. M., Lyons, J. F., Haslett, C. & Rossi, A. G., 30 Sept 2011, In: PLoS ONE. 6, 9, p. - 10 p., e25683.

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C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients

Morris, A. C., Brittan, M., Wilkinson, T. S., McAuley, D. F., Antonelli, J., McCulloch, C., Barr, L. C., McDonald, N. A., Dhaliwal, K., Jones, R., Mackellar, A., Haslett, C., Hay, A. W., Swann, D. G., Anderson, N., Laurenson, I. F., Davidson, D. J., Rossi, A. G., Walsh, T. S. & Simpson, A. J., 12 May 2011, In: Blood. 117, 19, p. 5178-5188 11 p.

Research output: Contribution to journal › Article › peer-review

Mechanisms of Resolution of Inflammation A Focus on Cardiovascular Disease

Maskrey, B. H., Megson, I. L., Whitfield, P. D. & Rossi, A. G., May 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 5, p. 1001-1006 6 p.

Research output: Contribution to journal › Article › peer-review

Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells

Shaw, C. A., Taylor, E. L., Fox, S., Megson, I. L. & Rossi, A. G., 1 Jan 2011, In: Free Radical Biology and Medicine. 50, 1, p. 93-101 9 p.

Research output: Contribution to journal › Article › peer-review

5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

Yang, CHENYING., Nixon, M., Kenyon, C. J., Livingstone, D. E. W., Duffin, R., Rossi, A. G., Walker, B. R. & Andrew, R., 2011, In: British Journal of Pharmacology. 164, 6, p. 1661-71 11 p.

Research output: Contribution to journal › Article › peer-review

Leukocyte migratory responses to apoptosis: the attraction and the distraction

Gregory, C. D., Rossi, A. G., Bournazou, I., Zhang, L. & Willems, J. J. L. P., 2011, In: Cell Adhesion and Migration. 5, 4, p. 293-7 5 p.

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Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways

Festa, M., Capasso, A., D'Acunto, C. W., Masullo, M., Rossi, A. G., Pizza, C. & Piacente, S., 2011, In: Journal of natural products. 74, 12, p. 2505-13 9 p.

Research output: Contribution to journal › Article › peer-review

2010

PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner

Sousa, L. P., Lopes, F., Silva, D. M., Tavares, L. P., Vieira, A. T., Rezende, B. M., Carmo, A. F., Russo, R. C., Garcia, C. C., Bonjardim, C. A., Alessandri, A. L., Rossi, A. G., Pinho, V. & Teixeira, M. M., May 2010, In: Journal of Leukocyte Biology. 87, 5, p. 895-904 10 p.

Research output: Contribution to journal › Article › peer-review

NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy

Fox, S., Wilkinson, T. S., Wheatley, P. S., Xiao, B., Morris, R. E., Sutherland, A., Simpson, A. J., Barlow, P. G., Butler, A. R., Megson, I. L. & Rossi, A. G., Apr 2010, In: Acta Biomaterialia. 6, 4, p. 1515-1521 7 p.

Research output: Contribution to journal › Article › peer-review

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

Leitch, A. E., Riley, N. A., Sheldrake, T. A., Festa, M., Fox, S., Duffin, R., Haslett, C. & Rossi, A. G., Apr 2010, In: European Journal of Immunology. 40, 4, p. 1127-1138 12 p.

Research output: Contribution to journal › Article › peer-review

Inhibition of eosinophil migration by lactoferrin

Bournazou, I., Mackenzie, K. J., Duffin, R., Rossi, A. G. & Gregory, C. D., Feb 2010, In: Immunology & Cell Biology. 88, 2, p. 220-223 4 p.

Research output: Contribution to journal › Article › peer-review

2009

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

Li, H-N., Barlow, P. G., Bylund, J., Mackellar, A., Bjorstad, A., Conlon, J., Hiemstra, P. S., Haslett, C., Gray, M., Simpson, A. J., Rossi, A. G. & Davidson, D. J., Oct 2009, In: Journal of Leukocyte Biology. 86, 4, p. 891-902 12 p.

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Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-kappa B

Sousa, L. P., Carmo, A. F., Rezende, B. M., Lopes, F., Silva, D. M., Alessandri, A. L., Bonjardim, C. A., Rossi, A. G., Teixeira, M. M. & Pinho, V., 15 Aug 2009, In: Biochemical Pharmacology. 78, 4, p. 396-405 10 p.

Research output: Contribution to journal › Article › peer-review

C5a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients

Conway-Morris, A., Kefala, K., Wilkinson, T. S., Dhaliwal, K., Farrell, L., Walsh, T., Mackenzie, S. J., Reid, H., Davidson, D. J., Haslett, C., Rossi, A. G., Sallenave, J-M. & Simpson, A. J., 1 Jul 2009, In: American Journal of Respiratory and Critical Care Medicine. 180, 1, p. 19-28 10 p.

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Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

Shaw, C. A., Webb, D. J., Rossi, A. G. & Megson, I. L., May 2009, In: Journal of inflammation. 6, 10 p., 14.

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Enzyme-Independent NO Stores in Human Skin: Quantification and Influence of UV Radiation

Mowbray, M., McLintock, S., Weerakoon, R., Lomatschinsky, N., Jones, S., Rossi, A. G. & Weller, R. B., Apr 2009, In: Journal of Investigative Dermatology. 129, 4, p. 834-842 9 p.

Research output: Contribution to journal › Article › peer-review

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-alpha

Michlewska, S., Dransfield, I., Megson, I. L. & Rossi, A. G., Mar 2009, In: The FASEB Journal. 23, 3, p. 844-54 11 p.

Research output: Contribution to journal › Article › peer-review

Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies

Mackinnon, A. C., Tufail-hanif, U., Wheatley, M., Rossi, A. G., Haslett, C., Seckl, M. & Sethi, T., 1 Jan 2009, In: British Journal of Pharmacology. 156, 1, p. 36-47

Research output: Contribution to journal › Article › peer-review

Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin

Bournazou, I., Pound, J. D., Duffin, R., Bournazos, S., Melville, L. A., Brown, S. B., Rossi, A. G. & Gregory, C. D., Jan 2009, In: Journal of Clinical Investigation. 119, 1, p. 20-32 13 p.

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Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma

Wallace, A. E., Sales, K. J., Catalano, R. D., Anderson, R. A., Williams, A. R. W., Wilson, M. R., Schwarze, J., Wang, H., Rossi, A. G. & Jabbour, H. N., 2009, In: Cancer Research. 69, 14, p. 5726-33 8 p.

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The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

Duffin, R., Leitch, A. E., Sheldrake, T. A., Hallett, J. M., Meyer, C., Fox, S., Alessandri, A. L., Martin, M. C., Brady, H. J., Teixeira, M. M., Dransfield, I., Haslett, C. & Rossi, A. G., 2009, In: FEBS Letters. 583, 15, p. 2540-6 7 p.

Research output: Contribution to journal › Article › peer-review

2008

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

Turnbull, C. M., Marcarino, P., Sheldrake, T. A., Lazzarato, L., Cena, C., Fruttero, R., Gasco, A., Fox, S., Megson, I. L. & Rossi, A. G., 31 Jul 2008, In: Journal of inflammation. 5, p. - 10 p., 12.

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The anti-inflammatory effects and the inhibition of neutrophil responsiveness by Barleria lupulina and Clinacanthus nutans extracts

Wanikiat, P., Panthong, A., Sujayanon, P., Yoosook, C., Rossi, A. G. & Reutrakul, V., 2008, In: Journal of ethnopharmacology. 116, 2, p. 234-44 11 p.

Research output: Contribution to journal › Article › peer-review

2007

GEA 3162, a peroxynitrite donor, induces Bcl-2-sensitive, p53-independent apoptosis in murine bone marrow cells

Taylor, E. L., Li, J. T., Tupper, J. C., Rossi, A. G., Winn, R. K. & Harlan, J. M., 1 Oct 2007, In: Biochemical Pharmacology. 74, 7, p. 1039-1049

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Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints

Barton, N. J., Stevens, D. A., Hughes, J. P., Rossi, A. G., Chessell, I. P., Reeve, A. J. & Mcqueen, D. S., 1 Jan 2007, In: Journal of inflammation. 4, 1, p. 13

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Analysis of neutrophil apoptosis

Taylor, E. L., Rossi, A. G., Dransfield, I. & Hart, S. P., 2007, In: Methods in Molecular Biology. 412, p. 177-200 24 p.

Research output: Contribution to journal › Article › peer-review

Effects of glucocorticoids on apoptosis and clearance of apoptotic cells

McColl, A., Michlewska, S., Dransfield, I. & Rossi, A. G., 2007, In: Scientific World Journal. 7, p. 1165-81 17 p.

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Induction of neutrophil apoptosis and treatment of severe lung inflammation

Research output

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