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Invasion and metastasis; understanding and targeting an adhesion protein network - Programme Grant Renewal
Frame, Margaret
(Principal Investigator)
Deanery of Molecular, Genetic and Population Health Sciences
Overview
Fingerprint
Research output
(31)
Project Details
Status
Finished
Effective start/end date
1/05/13
→
31/08/18
Funding
UK-based charities:
£2,012,920.00
View all
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Focal Adhesion Protein-Tyrosine Kinases
Medicine & Life Sciences
100%
Neoplasms
Medicine & Life Sciences
44%
Interleukin-33
Medicine & Life Sciences
31%
Breast Neoplasms
Medicine & Life Sciences
30%
AZD-0424
Medicine & Life Sciences
27%
Squamous Cell Carcinoma
Medicine & Life Sciences
27%
Autophagy
Medicine & Life Sciences
24%
Ponatinib
Chemical Compounds
22%
Research output
Research output per year
2014
2015
2016
2017
2018
2019
2021
2022
28
Article
2
Literature review
1
Review article
Research output per year
Research output per year
Characterisation of a nucleo-adhesome
Byron, A.
,
Griffith, B.
,
Herrero Mier, A.
,
Loftus, A. E. P.
,
Koeleman, E. S.
,
Kogerman, L.
,
Dawson, J. C.
,
McGivern, N.
,
Culley, J.
,
Grimes, G. R.
,
Serrels, B.
,
von Kriegsheim, A.
,
Brunton, V. G.
&
Frame, M. C.
,
1 Jun 2022
, (E-pub ahead of print)
In:
Nature Communications.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
proteins
100%
Nuclear Proteins
97%
adhesion
90%
characterization
69%
Protein
51%
Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors
Dawson, J. C.
,
Munro, A.
,
Macleod, K.
,
Muir, M.
,
Timpson, P.
,
Williams, R. J.
,
Frame, M. C.
,
Brunton, V. G.
&
Carragher, N. O.
,
2 Dec 2021
, (E-pub ahead of print)
In:
Molecular Oncology.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
AZD-0424
100%
trametinib
54%
Mitogen-Activated Protein Kinase Kinases
44%
AZD 6244
19%
Cell Line
13%
A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability
Temps, C., Leitha, D.,
Webb, E.
,
Li, X-F.
,
Dawson, J. C.
, Muir, M., Macleod, K., Valero, T.,
Munro, A.
, Contreras-montoya, R., Luque-Ortega, J. R., Fraser, C., Beetham, H., Schoenherr, C., Lopalco, M.,
Arends, M. J.
,
Frame, M. C.
,
Qian, B-Z.
,
Brunton, V. G.
,
Carragher, N. O.
& 1 others
,
Unciti-Broceta, A.
,
20 Aug 2021
, (E-pub ahead of print)
In:
Cancer Research.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Pharmaceutical Preparations
100%
Phosphotransferases
62%
Phosphorylation
55%
Neoplasms
51%
Therapeutics
39%