Investigating the roles of follicular dendritic cells in TSE agent neuroinvasion from lymphoid tissues

Project Details

Key findings

-Demonstrated for the first time that follicular dendritic cells alone are the important sites of TSE agent accumulation in lymphoid tissues.



-Demonstrated for the first time that the specific ablation of PrPC expression only on FDC blocked TSE agent accumulation in lymphoid tissues and subsequent neuroinvasion.
StatusFinished
Effective start/end date1/05/0831/08/14

Funding

  • BBSRC: £162,386.00

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