Research output per year
Research output per year
Project Details
Layman's description
Chicken and mouseEmbryos which lack functional TALPID3 protein die during development.
Key findings
TALPID3 protein is a centrosomal protein
It is postulated through analysis of TALPID3 homologues that TALPID3 has a Eumetazoan origin
TALPID3 has 2 essential coiled coiled domains
TALPID3 has 1 essential region of intrisic disorder
TALPID3 is essential for motile and non-motile cilia development
TALPID3 is essential for migration and orientation of centrosomes during ciliogenesis
TALPID3 is not essential for centriol duplication
TALPID3 is not essential for axoneme formation
Telencephalic choroid plexus forms in in talpid3-/- chicken embryos
Lung development is abnormal in talpid3-/- and phenocopies human ciliopathy syndromes
Liver development is abnormal in talpid3-/- and phenocopies human ciliopathy syndromes
Inner ear development is abnormal in talpid3-/- and phenocopies human ciliopathy syndromes
talpid3-/- embryos have planar cell polarity type anatomical defects
talpid3-/- embryos/cells have intracellular mislocalisation of core planar cell polarity proteins
TALPID3 is epistatic to KIF7
It is postulated through analysis of TALPID3 homologues that TALPID3 has a Eumetazoan origin
TALPID3 has 2 essential coiled coiled domains
TALPID3 has 1 essential region of intrisic disorder
TALPID3 is essential for motile and non-motile cilia development
TALPID3 is essential for migration and orientation of centrosomes during ciliogenesis
TALPID3 is not essential for centriol duplication
TALPID3 is not essential for axoneme formation
Telencephalic choroid plexus forms in in talpid3-/- chicken embryos
Lung development is abnormal in talpid3-/- and phenocopies human ciliopathy syndromes
Liver development is abnormal in talpid3-/- and phenocopies human ciliopathy syndromes
Inner ear development is abnormal in talpid3-/- and phenocopies human ciliopathy syndromes
talpid3-/- embryos have planar cell polarity type anatomical defects
talpid3-/- embryos/cells have intracellular mislocalisation of core planar cell polarity proteins
TALPID3 is epistatic to KIF7
| Status | Finished |
|---|---|
| Effective start/end date | 1/07/08 → 28/02/14 |
Funding
- BBSRC: £1,378,066.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)
Stephen, L. A., Tawamie, H., Davis, G. M., Tebbe, L., Nürnberg, P., Nürnberg, G., Thiele, H., Thoenes, M., Boltshauser, E., Uebe, S., Rompel, O., Reis, A., Ekici, A. B., McTeir, L., Fraser, A. M., Hall, E., Mill, P., Daudet, N., Cross, C., Wolfrum, U., & 3 others, 19 Sept 2015, In: eLIFE. 4, September, p. 1-22 22 p., 2015;4:e08077.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly
Johnson, E. J., Neely, D. M., Dunn, I. C. & Davey, M. G., 5 Jun 2014, In: Developmental Biology. 392, 2, p. 209–220Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The chicken left right organizer has nonmotile cilia which are lost in a stage-dependent manner in the talpid3 ciliopathy
Stephen, L. A., Johnson, E. J., Davis, G. M., Mcteir, L., Pinkham, J., Jaberi, N. & Davey, M. G., 2 Apr 2014, In: genesis: The Journal of Genetics and Development. 52, 6, p. 600-613Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
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What's In an Egg
Megan Davey (Presenter)
2 Mar 2014Activity: Participating in or organising an event types › Public Engagement – Schools engagement
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3rd Annual Nordic Cilia and Centrosome Meeting
Megan Davey (Invited speaker)
2 Feb 2013Activity: Participating in or organising an event types › Participation in conference
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National Science and Engineering Competition 2013
Megan Davey (Contributor)
15 Mar 2013 → 17 Mar 2013Activity: Participating in or organising an event types › Public Engagement – Festival/Exhibition