Investigation of the role of the primary cilia and centrosome during signalling events in development using the chicken mutant TALPID3: Fellowship Dr M Davey

Research output

Research output per year 2008 2009 2014 2015

• 10 Article
• 8 Abstract
• 6 Meeting abstract
• 1 Conference contribution
• 1 More
  • 1 Paper

Research output per year

Research output per year

Search results

• 2015

  TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)

  Stephen, L. A., Tawamie, H., Davis, G. M., Tebbe, L., Nürnberg, P., Nürnberg, G., Thiele, H., Thoenes, M., Boltshauser, E., Uebe, S., Rompel, O., Reis, A., Ekici, A. B., McTeir, L., Fraser, A. M., Hall, E., Mill, P., Daudet, N., Cross, C. & Wolfrum, U. & 3 others, Jamra, R. A., Davey, M. G. & Bolz, H. J., 19 Sept 2015, In: eLIFE. 4, September, p. 1-22 22 p., 2015;4:e08077.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Polarity 100%
  • Centrosome 100%
  • Orthology 100%
  • Animal Models 50%
  • Exome Sequencing 50%
• 2014

  Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly

  Johnson, E. J., Neely, D. M., Dunn, I. C. & Davey, M. G., 5 Jun 2014, In: Developmental Biology. 392, 2, p. 209–220

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hedgehog Signaling Pathway 100%
  • Sonic Hedgehog 100%
  • Enhancer Region 100%
  • Allele 20%
  • Hedgehog 13%

• The chicken left right organizer has nonmotile cilia which are lost in a stage-dependent manner in the talpid3 ciliopathy

  Stephen, L. A., Johnson, E. J., Davis, G. M., Mcteir, L., Pinkham, J., Jaberi, N. & Davey, M. G., 2 Apr 2014, In: genesis: The Journal of Genetics and Development. 52, 6, p. 600-613

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cilium 100%
  • Ciliopathy 100%
  • Primary Cilium 10%
  • Cell Polarity 10%
  • Mouse 9%

• Loss of cilia causes embryonic lung hypoplasia, liver fibrosis and cholestasis in the talpid3 ciliopathy mutant

  Davey, M., McTeir, L., Barrie, A., Freem, L. & Stephen, L., Apr 2014, In: Organogenesis. 10, 2, p. 177-185

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cilium 100%
  • Intrahepatic Cholestasis 100%
  • Lung Hypoplasia 100%
  • Hedgehog Signaling Pathway 83%
  • Liver Development 83%

• TALPID3 is a Centrosomal Protein Working in the Wnt/PCP Pathway

  Stephen, L., McTeir, L., Davis, G. & Davey, M., 2014.

  Research output: Contribution to conference › Abstract

• 2013

  Failure of centrosome migration causes a loss of motile cilia in talpid³ mutants

  Stephen, L. A., Davis, G., McTeir, K. E., James, J., McTeir, L., Kierans, M., Bain, A. & Davey, M. G., Aug 2013, In: Developmental Dynamics. 242, 8, p. 923-931

  Research output: Contribution to journal › Article › peer-review

  • Cilium 100%
  • Centrosome 100%
  • Ependymal Cell 80%
  • Primary Cilium 60%
  • Choroid Plexus 40%

• Is TALPID3 a PCP Pathway Protein?

  Stephen, L., McTeir, L., McTeir, K., James, J. & Davey, M., 18 Mar 2013.

  Research output: Contribution to conference › Abstract

  • Cilium 100%
  • Centrosome 100%
  • Hedgehog Signaling 100%
  • Hedgehog Signaling Pathway 100%
  • Hedgehog 100%

• The development of multi-ciliated cells in chicken embryos

  McTeir, K., McTeir, L. & Davey, M., 13 Mar 2013.

  Research output: Contribution to conference › Paper

  • Cerebrospinal Fluid 100%
  • Cell Maturation 100%
  • Central Nervous System 100%
  • Cell Fate 100%
  • Ciliopathy 100%
• 2012

  Is TALPID3 a Wnt/PCP pathway gene?

  Davey, M., 5 Dec 2012.

  Research output: Contribution to conference › Abstract

  • Hedgehog Signaling Pathway 100%
  • Centrosome 75%
  • Maternal Effect 75%
  • Cilium 50%
  • Zebra Fish 50%

• The role of TALPID3 during cell signalling and early development

  Davey, M., McTeir, L. & McGrew, M., 30 Nov 2012, p. Talpid3.

  Research output: Contribution to conference › Abstract

  • Hedgehog Signaling Pathway 100%
  • Maternal Effect 100%
  • Early Development 100%
  • Hedgehog 100%
  • Cilium 66%

• The Function of TALPID3

  Davey, M., 1 Feb 2012, p. 17. 1 p.

  Research output: Contribution to conference › Abstract

  • Coiled Coil 100%
  • Centrosome 75%
  • Hedgehog Signaling Pathway 50%
  • Yeast Two-Hybrid Screening 25%
  • Essential Gene 25%
• 2011

  Generation of mice with functional inactivation of talpid3, a gene first identified in chicken

  Bangs, F., Antonio, N., Thongnuek, P., Welten, M., Davey, M. G., Briscoe, J. & Tickle, C., Aug 2011, In: Development. 138, 15, p. 3261-3272 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Limb 100%
  • Hedgehog Signaling Pathway 100%
  • Hedgehog Signaling 75%
  • Primary Cilium 66%
  • Exon 66%

• TALPID3 - From the chicken to human and back again

  Davey, M. & McTeir, L., 2011, p. 78 Abstract 106.

  Research output: Contribution to conference › Abstract

• 2010

  Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

  Cruz, C., Ribes, V., Kutejova, E., Cayuso, J., Lawson, V., Norris, D., Stevens, J., Davey, M., Blight, K., Bangs, F., Mynett, A., Hirst, E., Chung, R., Balaskas, N., Brody, S. L., Marti, E. & Briscoe, J., 2010, In: Development. 137, 24, p. 4271-4282 12 p.

  Research output: Contribution to journal › Article › peer-review

  File

• Identification of genes downstream of the Shh signalling in the developing chick wing and syn-expressed with Hoxd13 using microarray and 3D computational analysis

  Bangs, F., Welten, M., Davey, M. G., Fisher, M., Yin, Y., Downie, H., Paton, B., Baldock, R., Burt, D. W. & Tickle, C., 2010, In: Mechanisms of Development. 127, 9-12, p. 428-41 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Hedgehog Signaling Pathway 100%
  • Chick 100%
  • Sonic Hedgehog 100%
  • Sonic Hedgehog Protein 100%
  • Hedgehog Signaling 100%

• Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick

  MacRae, V., Davey, M., McTeir, L., Narisawa, S., Yadav, M. C., Millan, J. L. & Farquharson, C., 2010, In: Bone. 46, 4, p. 1146-55 10 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Limb Development 100%
  • Disulfide 33%
  • Beta Defensin 30%
  • Disulfide Bond 30%
  • Antimicrobial Agent 20%
• 2009

  13-P093 Defects in gut and enteric nervous system development in talpid3 mutant chicken

  Burns, A., Bradshaw, L., Davey, M. & Thapar, N., Aug 2009, Mechanisms of Development.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Smooth Muscle 100%
  • Nervous System Development 100%
  • Intestine Innervation 100%
  • Neurogenesis 100%
  • Gut 100%

• A functional role of PHOSPHO1 in mineralisation during chick limb development

  MacRae, V. E., Davey, M. G., McTeir, L., Narisawa, S., Yadav, M. C., Millan, J. L. & Farquharson, C., 2009, In: Calcified Tissue International and Musculoskeletal Research. 85, 2, p. 166, abstract P003

  Research output: Contribution to journal › Meeting abstract › peer-review

• Analysis of talpid3 mutant chicken embryos reveals defects in gut and enteric nervous system development

  Burns, A. J., Bradshaw, L., Freem, L. J., Davey, M. G. & Thapar, N., 2009, p. 223,III-223,III.

  Research output: Contribution to conference › Abstract

• Defects in gut and enteric nervous system development in talpid3 mutant chicken

  Burns, A., Bradshaw, L., Davey, M. & Thapar, N., 2009, In: Mechanisms of Ageing and Development. 126, Supplement 1, p. S222-S223 abstract 13-PO93

  Research output: Contribution to journal › Meeting abstract › peer-review

• Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development

  MacRae, V., Davey, M., McTeir, L., Narisawa, S., Yadav, M., Millan, J. & Farquharson, C., 2009, In: Journal of Bone and Mineral Research. 24, Supplement 1, p. abstract A09001574

  Research output: Contribution to journal › Meeting abstract › peer-review

  File

• Left/right axis specification in the cilia mutant talpid(3)

  Pinkham, J., McTeir, L. & Davey, M., 2009, In: Mechanisms of Development. 126, Supplement 1, p. S187-S187 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

  • Cilium 100%
  • Hedgehog 100%
  • Hedgehog Signaling Pathway 60%
  • Polydactyly 25%
  • Neural Tube 20%

• The developmental mutant talpid 3 lacks primary cilia

  Bangs, F., Yin, Y. L., Paton, R., Prescott, A., James, J., Davey, M., Whitley, P., Genikhovich, G., Technau, U., Briscoe, J., Burt, D. & Tickle, C., 2009, In: Mechanisms of Ageing and Development. 126, Supplement 1, p. S262, abstract 16-P0002

  Research output: Contribution to journal › Meeting abstract › peer-review

• The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

  Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. & Tickle, C., 2009, In: Development. 136, 4, p. 655-64 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sea Anemone 100%
  • Translocator Protein 100%
• 2008

  Temporal expression of PHOSPHO1 during chick limb bud mesenchymal cell differentiation and mineralisation

  MacRae, V. E., Davey, M., Narisawa, S., Yadav, M. C., Millan, J. L. & Farquharson, C., 2008, In: Calcified Tissue International and Musculoskeletal Research. 83, 1, p. 9 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• The chicken mutant talpid 3 : from the tips of the fingers to the tip of the cilia

  Davey, M., 2008.

  Research output: Contribution to conference › Abstract