Leucine and ACE inhibitors as therapies for sarcopenia: a two by two factorial randomised placebo controlled trial

Duncan, Gordon (Principal Investigator)

Deanery of Clinical Sciences

Description

EudraCT No: 2014-003455-61

NIHR-funded CTIMP which is investigating whether supplementation with the essential amino acid leucine and/or perindopril will improve muscle mass and function in older people with sarcopenia.

CI: Dr Miles Witham
Sponsor: University of Dundee

Acronym	LACE
Status	Active
Effective start/end date	21/02/16 → …
Links	http://www.lacetrial.org.uk/

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2 Article

Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial
Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T., Avenell, A., Band, M. M., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Hume, C., Jackson, T. A., Kerr, S., Kilgour, A. & Masud, T. & 15 others, McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Rossios, C., Sayer, A. A., Smith, K. T., Soiza, R. L., Steves, C. J., Struthers, A. D., Tiwari, D., Whitney, J., Witham, M. D. & Kemp, P. R., 14 Nov 2023, In: PLOS ONE. 18, 11, 18 p., e0294330.
Research output: Contribution to journal › Article › peer-review

Open Access
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ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial
Rossios, C., Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T., Avenell, A., Band, M. M., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Hume, C., Jackson, T. A., Kerr, S. & Kilgour, A. & 15 others, Masud, T., McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Sayer, A. A., Smith, K. T., Soiza, R. L., Steves, C. J., Struthers, A. D., Tiwari, D., Whitney, J., Witham, M. D. & Kemp, P. R., 20 Oct 2023, In: PLOS ONE. 18, 10, 17 p., e0292402.
Research output: Contribution to journal › Article › peer-review

Open Access
File

Leucine and ACE inhibitors as therapies for sarcopenia: a two by two factorial randomised placebo controlled trial

Project Details

Description

Access Project

Fingerprint

Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial

ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial

Leucine and ACE inhibitors as therapies for sarcopenia: a two by two factorial randomised placebo controlled trial

Project Details

Description

Access Project

Fingerprint

Research output

Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial

ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial