Activities per year
This was a collaborative project in which a novel gene designed to block MDV replication in chicken cells was developed by collaborators. This specific part of the project involved production of genetically-modified chickens carrying this new gene and testing the response of these chickens to infection with MDV.
Marek's disease (MDV) is a major viral disease of commercial chickens. The virus is very robust and hard to clean from poultry housing. Vaccines are used to control infections with MDV but they are not fully protective and the strains of MDV are becoming more virulent. The aim of this project was to investigate a novel approach to control of MDV by using genetic modification to block infection in every chicken carrying a new gene.
Genetically modified chickens were generated that expressed the small RNA molecules that had been shown to affect MDV replication in a test system. We could not detect greater resistance to MDV infection in these birds. The project did demonstrate that small interfering RNA molecules can be introduced into chickens and the RNAs found in all tissues.
|Effective start/end date||1/05/08 → 30/07/10|
- BBSRC: £38,025.00
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
GM animals and GM food
Helen Sang (Contributor)25 Feb 2014
Activity: Consultancy types › Providing oral or written evidence for non-academic board, committee, working group or advisory panel
Edinburgh Festival Fringe
Helen Sang (Presenter)24 Aug 2014
Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
Genetic modification of chickens: technologies for the future?
Helen Sang (Contributor)22 Apr 2014
Activity: Academic talk or presentation types › Invited talk