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Mechanisms for regulating mammalian axon guidance by differential sulphation of heparan sulphate
Pratt, Thomas
(Principal Investigator)
Mason, John
(Co-investigator)
Price, David
(Co-investigator)
Deanery of Biomedical Sciences
Overview
Fingerprint
Research output
(2)
Project Details
Status
Finished
Effective start/end date
13/10/08
→
12/01/12
Funding
MRC:
£704,420.00
View all
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Heparan Sulfate
Biochemistry, Genetics and Molecular Biology
100%
Sulfation
Biochemistry, Genetics and Molecular Biology
62%
Sulfotransferase
Biochemistry, Genetics and Molecular Biology
55%
Heparan
Pharmacology, Toxicology and Pharmaceutical Science
55%
Signaling Protein
Biochemistry, Genetics and Molecular Biology
30%
Biological Activity
Biochemistry, Genetics and Molecular Biology
25%
Wild Type
Biochemistry, Genetics and Molecular Biology
18%
Mouse Mutant
Biochemistry, Genetics and Molecular Biology
18%
Research output
Research output per year
2014
2014
2015
2015
2
Article
Research output per year
Research output per year
2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline
Chan, W. K.
,
Howe, K.
,
Clegg, J. M.
,
Guimond, S. E.
,
Price, D.
,
Turnbull, J. E.
&
Pratt, T.
,
15 Jun 2015
,
In:
PLoS ONE.
10
,
6
, e0130147.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Sulfation
100%
Heparan Sulfate
100%
Nervous System Development
11%
Embryogenesis
11%
Wild Type
11%
Heparan sulfotransferases hs6st1 and hs2st keep erk in check for mouse corpus callosum development
Clegg, J. M.
,
Conway, C. D.
,
Howe, K. M.
,
Price, D. J.
,
Mason, J. O.
,
Turnbull, J. E.
,
Basson, M. A.
&
Pratt, T.
,
5 Feb 2014
,
In:
Journal of Neuroscience.
34
,
6
,
p. 2389-401
13 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Heparan Sulfate
100%
Sulfotransferase
100%
Heparan
100%
Signaling Protein
50%
Biological Activity
50%