MRNA LOCALIZATION

  • Davis, Ilan (Principal Investigator)
  • Finnegan, David (Co-investigator)

Project Details

Key findings

1. Identification of a structure within the RNA transpositon intermediate of the I factor that is necessary and sufficient for move to the nucleus in the oocyte of Drosophila.
2. This structure is similar to that required for a developmentally important messenger RNA to move to the nucleus in the oocyte.
3. Demonstration that these RNAs are moved through the nucleus by related transport proteins.
4. Identification of two protein that are required to move the RNA to the nucleus and allow it to accumulate there.
5. Production of an automated method to identify RNAs that contain any similar structures. This allowed us to identify other RNA transposition intermediates that are transported to the oocyte nucleus.
StatusFinished
Effective start/end date1/03/0528/02/07

Funding

  • EU government bodies: £102,610.00

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