Neuronal network dysfunction in Alzheimer's disease

The early stages of Alzheimer's disease (AD) are associated with selective deficits in memory processes. The lab aims to identify the neuronal circuit mechanisms that underlie the specific cognitive impairments in the early stages of AD. We propose that identifying the cells and synapses that are affected early in disease progression can shed light on the causes of AD, as well as reveal new therapeutic targets. We study rodent models of AD using a combination of in vitro and in vivo electrophysiology, optogenetics, cellular imaging and immunohistochemistry. A number of projects are currently available in the lab.