Optimising Innate Host Defence to Combat Antimicrobial Resistance

Dockrell, David (Principal Investigator)
Baillie, Kenneth (Co-investigator)
Bradley, Mark (Co-investigator)
Brown, Helen (Co-investigator)
Dhaliwal, Kevin (Co-investigator)
Fitzgerald, Ross (Co-investigator)
Haslett, Christopher (Co-investigator)
Hume, David (Co-investigator)
Rossi, Adriano (Co-investigator)
Walmsley, Sarah (Co-investigator)
Whyte, Moira (Co-investigator)

11 Article
1 Editorial

12 results

2024
Clinical sub-phenotypes of Staphylococcus aureus bacteraemia
Swets, M. C., Bakk, Z., Westgeest, A. C., Berry, K., Cooper, G., Sim, W., Lee, R. S., Gan, T. Y., Donlon, W., Besu, A., Heppenstall, E., Tysall, L., Dewar, S., de Boer, M., Fowler Jr., V. G., Dockrell, D. H., Thwaites, G., Pujol, M., Pallares, N., Tebe, C., & 4 othersCarratala, J., Szubert, A., Groeneveld, G. H. & Russell, C. D., 25 Jun 2024, In: Clinical Infectious Diseases. 79, 5, p. 1153-1161
Research output: Contribution to journal › Article › peer-review

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Experimental evolution of Staphylococcus aureus in macrophages: dissection of a conditional adaptive trait promoting intracellular survival
Alves, J., Vrieling, M., Ring, N., Yebra, G., Pickering, A., Prajsnar, T. K., Renshaw, S. A. & Fitzgerald, R., 12 Jun 2024, In: mBio. 15, 6, p. 1-19 19 p.
Research output: Contribution to journal › Article › peer-review

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2023

Moving into the red – a near infra-red optical probe for analysis of human neutrophil elastase in activated neutrophils and neutrophil extracellular traps
Rodriguez-Rios, M., Rinaldi, G., Megia-Fernandez, A., Lilienkampf, A., Robb, C. T., Rossi, A. G. & Bradley, M., 11 Sept 2023, (E-pub ahead of print) In: Chemical Communications.
Research output: Contribution to journal › Article › peer-review

Open Access
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2022

Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19?
Dockrell, D. H., Russell, C. D., McHugh, B. & Fraser, R., 1 Dec 2022, In: European Respiratory Journal. 60, 6, 2201521.
Research output: Contribution to journal › Editorial › peer-review

Open Access
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Epidemiological analysis of Legionnaires’ disease in Scotland: a genomic study
Gorzynski, J., Wee, B. A., Llano, M., Alves, J., Cameron, R. L., McMenamin, J., Smith, A., Lindsay, D. & Fitzgerald, R., 11 Oct 2022, (E-pub ahead of print) In: The Lancet Microbe. 3, p. e835–45
Research output: Contribution to journal › Article › peer-review

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2021
Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing
Wee, B. A., Alves, J., Lindsay, D. S. J., Klatt, A-B., Sargison, F. A., Cameron, R. L., Pickering, A., Gorzynski, J., Corander, J., Marttinen, P., Opitz, B., Smith, A. J. & Fitzgerald, J. R., 9 Dec 2021, In: Nature Communications. 12, 1, 7165.
Research output: Contribution to journal › Article › peer-review

Open Access
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Near-Infrared-Emitting Hemicyanines and Their Photodynamic Killing of Cancer Cells
Santra, M., Owens, M., Birch, G. & Bradley, M., 29 Nov 2021, (E-pub ahead of print) In: ACS Applied Biomaterials.
Research output: Contribution to journal › Article › peer-review

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Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages
Cole, J., Angyal, A., Emes, R. D., Mitchell, T. J., Dickman, M. J. & Dockrell, D. H., 17 May 2021, In: Frontiers in Immunology. 12
Research output: Contribution to journal › Article › peer-review

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2020
Population analysis of Staphylococcus aureus reveals a cryptic, highly prevalent superantigen SElW that contributes to the pathogenesis of bacteremia
Vrieling, M., Tuffs, S. W., Yebra, G., Smoorenburga, M. Y. V., Alves, J., Pickering, A., Park, J. Y., Park, N., Heinrichs, D. E., Benedictus, L., Connelley, T., Seo, K. S., McCormick, J. K. & Fitzgerald, R., 27 Oct 2020, (E-pub ahead of print) In: mBio.
Research output: Contribution to journal › Article › peer-review

Open Access
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Acapsular Staphylococcus aureus with a non-functional agr regains capsule expression after passage through the bloodstream in a bacteremia mouse model
Suligoy, C. M., Díaz, R. E., Gehrke, A-K., Ring, N., Yebra, G., Alves, J., Gómez, M. I., Wendler, S., Fitzgerald, J. R., Tuchscherr, L., Löffler, B., Sordelli, D. O., Llana, M. N. & Buzzola, F. R., 24 Aug 2020, In: Scientific Reports. 10, 1, p. 14108
Research output: Contribution to journal › Article › peer-review

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2019
A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species
Bacigalupe, R., Tormo-Mas, M. A., Penades, J. R. & Fitzgerald, J., 27 Nov 2019, In: Science Advances. 5, 11, p. 1-14 eaax0063.
Research output: Contribution to journal › Article › peer-review

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2018
Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists
COPDMAP, Bewley, M. A., Budd, R. C., Ryan, E., Cole, J., Collini, P., Marshall, J., Kolsum, U., Beech, G., Emes, R. D., Tcherniaeva, I., Berbers, G. A. M., Walmsley, S. R., Donaldson, G., Wedzicha, J. A., Kilty, I., Rumsey, W., Sanchez, Y., Brightling, C. E., Donnelly, L. E., & 4 othersBarnes, P. J., Singh, D., Whyte, M. K. B. & Dockrell, D. H., 15 Sept 2018, In: American Journal of Respiratory and Critical Care Medicine. 198, 6, p. 739-750 12 p.
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Optimising Innate Host Defence to Combat Antimicrobial Resistance

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