Orkney Cardiovascular Disease Study

2023

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

Zhao, J. H., Stacey, D., Eriksson, N., Macdonald-Dunlop, E., Hedman, Å. K., Kalnapenkis, A., Enroth, S., Cozzetto, D., Digby-Bell, J., Marten, J., Folkersen, L., Herder, C., Jonsson, L., Bergen, S. E., Gieger, C., Needham, E. J., Surendran, P., Paul, D. S., Polasek, O., Thorand, B., & 21 othersGrallert, H., Roden, M., Võsa, U., Esko, T., Hayward, C., Johansson, Å., Gyllensten, U., Powell, N., Hansson, O., Mattsson-Carlgren, N., Joshi, P. K., Danesh, J., Padyukov, L., Klareskog, L., Landén, M., Wilson, J. F., Siegbahn, A., Wallentin, L., Mälarstig, A., Butterworth, A. S. & Peters, J. E., 1 Sept 2023, In: Nature Immunology. 24, 9, p. 1540-1551 31 p.

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Genetic insights into resting heart rate and its role in cardiovascular disease

DCCT/EDIC Research Group, Campbell, A., Schraut, K. E., Joshi, P. K., Hayward, C., Porteous, D. J., Wilson, J. F. & van der Harst, P., 2 Aug 2023, In: Nature Communications. 14, 1, 21 p., 4646.

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Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene

Kentistou, K., Luan, J., Wittemans, L. B. L., Hambly, C., Klaric, L., Kutalik, Z., Speakman, J. R., Wareham, N. J., Kendall, T. J., Langenberg, C., Wilson, J. F., Joshi, P. K. & Morton, N. M., 19 Jan 2023, In: Nature Communications.

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2020

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Klaric, L., Tsepilov, Y. A., Stanton, C. M., Mangino, M., Sikka, T. T., Esko, T., Pakhomov, E., Salo, P., Deelen, J., McGurnaghan, S. J., Keser, T., Vučković, F., Ugrina, I., Krištić, J., Gudelj, I., Štambuk, J., Plomp, R., Pučić-Baković, M., Pavić, T., Vilaj, M., & 34 othersTrbojević Akmačić, I., Drake, C., Dobrinić, P., Timofeeva, M., Mlinarec, J., Jelušić, B., Richmond, A., Timofeeva, M., Grishchenko, A. K., Dmitrieva, J., Bermingham, M. L., Sharapov, S. Z., Farrington, S., Theodoratou, E., Uh, H-W., Beekman, M., Slagboom, E. P., Louis, E., Georges, M., Wuhrer, M., Colhoun, H. M., Dunlop, M. G., Perola, M., Fischer, K., Polasek, O., Campbell, H., Rudan, I., Wilson, J. F., Zoldos, V., Vitart, V., Spector, T., Aulchenko, Y. S., Lauc, G. & Hayward, C., 19 Feb 2020, In: Science Advances. 6, 8, eaax0301.

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2017

Determinants of retinal microvascular features and their relationships in two European populations

Kirin, M., Nagy, R., MacGillivray, T., Polasek, O., Hayward, C., Rudan, I., Campbell, H., Wild, S., Wright, A., Wilson, J. F. & Vitart, V., Aug 2017, In: Journal of Hypertension.

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2015

Homozygous loss-of-function variants in European cosmopolitan and isolate populations

Generation Scotland, UK10K, Kaiser, V. B., Svinti, V., Prendergast, J. G., Chau, Y-Y., Campbell, A., Patarcic, I., Barroso, I., Joshi, P. K., Hastie, N. D., Miljkovic, A., Taylor, M. S., Enroth, S., Memari, Y., Kolb-Kokocinski, A., Wright, A. F., Gyllensten, U., Durbin, R., Rudan, I., & 11 othersCampbell, H., Polašek, O., Johansson, Å., Sauer, S., Porteous, D. J., Fraser, R. M., Drake, C., Vitart, V., Hayward, C., Semple, C. A. & Wilson, J. F., 14 Jul 2015, In: Human Molecular Genetics.

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