PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY - Research output - University of Edinburgh Research Explorer

2013

Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort

ECLIPSE Investigators, Agusti, A., Edwards, L. D., Celli, B., MacNee, W., Calverley, P. M. A., Muellerova, H., Lomas, D. A., Wouters, E., Bakke, P., Rennard, S., Crim, C., Miller, B. E., Coxson, H. O., Yates, J. C., Tal-Singer, R. & Vestbo, J., Sept 2013, In: European Respiratory Journal. 42, 3, p. 636-646 11 p.

Research output: Contribution to journal › Article › peer-review

Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort

Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators, Miller, J., Edwards, L. D., Agustí, A., Bakke, P., Calverley, P. M. A., Celli, B., Coxson, H. O., Crim, C., Lomas, D. A., Miller, B. E., Rennard, S., Silverman, E. K., Tal-Singer, R., Vestbo, J., Wouters, E., Yates, J. C. & Macnee, W., Sept 2013, In: Respiratory Medicine. 107, 9, p. 1376-84 9 p.

Research output: Contribution to journal › Article › peer-review

Length-dependent pleural inflammation and parietal pleural responses after deposition of carbon nanotubes in the pulmonary airspaces of mice

Murphy, F. A., Poland, C. A., Duffin, R. & Donaldson, K., Sept 2013, In: Nanotoxicology. 7, 6, p. 1157-1167 11 p.

Research output: Contribution to journal › Article › peer-review

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

Currie, S. M., Gwyer Findlay, E., McHugh, B. J., Mackellar, A., Man, T., Macmillan, D., Wang, H., Fitch, P. M., Schwarze, J. & Davidson, D. J., 30 Aug 2013, In: PLoS ONE. 8, 8, 10 p., e73659.

Research output: Contribution to journal › Article › peer-review

Open Access

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Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

Marwick, J. A., Dorward, D. A., Lucas, C. D., Jones, K. O., Sheldrake, T. A., Fox, S., Ward, C., Murray, J., Brittan, M., Hirani, N., Duffin, R., Dransfield, I., Haslett, C. & Rossi, A. G., 20 Aug 2013, In: Journal of Leukocyte Biology. 94, 6, p. 1285-1292

Research output: Contribution to journal › Article › peer-review

Open Access

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A Randomized Controlled Trial of Peripheral Blood Mononuclear Cell Depletion in Experimental Human Lung Inflammation

Barr, L. C., Brittan, M., Conway Morris, A., McAuley, D. F., McCormack, C., Fletcher, A. M., Richardson, H., Connell, M., Patel, D., Wallace, W., Rossi, A. G., Davidson, D. J., Manson, L., Turner, M., Hirani, N., Walsh, T. S., Anderson, N. H., Dhaliwal, K. & Simpson, A. J., Aug 2013, In: American Journal of Respiratory and Critical Care Medicine. 188, 4, p. 449-455

Research output: Contribution to journal › Article › peer-review

Computed Tomography Angiography in the Diagnosis of ANCA-Associated Small- and Medium-Vessel Vasculitis

Dhaun, N., Patel, D. & Kluth, D. C., Aug 2013, In: American Journal of Kidney Diseases. 62, 2, p. 390-393 4 p.

Research output: Contribution to journal › Article › peer-review

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial

MacNee, W., Allan, R. J., Jones, I., De Salvo, M. C. & Tan, L. F., Aug 2013, In: Thorax. 68, 8, p. 738-45 8 p.

Research output: Contribution to journal › Article › peer-review

Surviving intensive care: a systematic review of healthcare resource use after hospital discharge*

Lone, N. I., Seretny, M., Wild, S. H., Rowan, K. M., Murray, G. D. & Walsh, T. S., Aug 2013, In: Critical Care Medicine. 41, 8, p. 1832-1843 12 p.

Research output: Contribution to journal › Article › peer-review

Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment

Doig, T., Hume, D. A., Theocharidis, T., Goodlad, J., Gregory, C. D. & Freeman, T. C., 11 Jul 2013, In: BMC Genomics. 14, n/a, 469.

Research output: Contribution to journal › Article › peer-review

Open Access

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Developing high-fidelity hepatotoxicity models from pluripotent stem cells

Medine, C. N., Lucendo-Villarin, B., Storck, C., Wang, F., Szkolnicka, D., Khan, F., Pernagallo, S., Black, J. R., Marriage, H. M., Ross, J. A., Bradley, M., Iredale, J. P., Flint, O. & Hay, D. C., Jul 2013, In: Stem Cells Translational Medicine. 2, 7, p. 505-9 5 p.

Research output: Contribution to journal › Article › peer-review

Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production

Dorward, D. A., Lucas, C. D., Alessandri, A. L., Marwick, J. A., Rossi, F., Dransfield, I., Haslett, C., Dhaliwal, K. & Rossi, A. G., Jul 2013, In: Journal of Leukocyte Biology. 94, 1, p. 193-202 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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CT-measured bone attenuation in patients with chronic obstructive pulmonary disease: relation to clinical features and outcomes

Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators, Romme, E. A. P. M., Murchison, J. T., Edwards, L. D., van Beek, E., Murchison, D. M., Rutten, E. P. A., Smeenk, F. W. J. M., Williams, M. C., Wouters, E. F. M. & MacNee, W., Jun 2013, In: Journal of Bone and Mineral Research. 28, 6, p. 1369-77 9 p.

Research output: Contribution to journal › Article › peer-review

Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23

Haines, C. J., Chen, Y., Blumenschein, W. M., Jain, R., Chang, C., Joyce-Shaikh, B., Porth, K., Boniface, K., Mattson, J., Basham, B., Anderton, S. M., McClanahan, T. K., Sadekova, S., Cua, D. J. & McGeachy, M. J., 30 May 2013, In: Cell Reports. 3, 5, p. 1378-1388 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Forced Expiratory Volume in One Second Predicts Length of Stay and In-Hospital Mortality in Patients Undergoing Cardiac Surgery: A Retrospective Cohort Study

Mcallister, D. A., Wild, S. H., Maclay, J. D., Robson, A., Newby, D. E., Macnee, W., Innes, J. A., Zamvar, V. & Mills, N. L., 28 May 2013, In: PLoS ONE. 8, 5, 8 p., e64565.

Research output: Contribution to journal › Article › peer-review

Open Access

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Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Bird, T. G., Lu, W.-Y., Boulter, L., Gordon-Keylock, S., Ridgway, R. A., Williams, M. J., Taube, J., Thomas, J. A., Wojtacha, D., Gambardella, A., Sansom, O. J., Iredale, J. P. & Forbes, S. J., 16 Apr 2013, In: Proceedings of the National Academy of Sciences (PNAS). 110, 16, p. 6542-6547 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Modification of the FoxP3 Transcription Factor Principally Affects Inducible T Regulatory Cells in a Model of Experimental Autoimmune Encephalomyelitis

Verhagen, J., Burton, B. R., Britton, G. J., Shepard, E. R., Anderton, S. M. & Wraith, D. C., 8 Apr 2013, In: PLoS ONE. 8, 4, p. e61334

Research output: Contribution to journal › Article › peer-review

Open Access

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Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

Montanaro, G., Bertinaria, M., Rolando, B., Fruttero, R., Lucas, C., Dorward, D. A., Rossi, A. G., Megson, I. L. & Gasco, A., 1 Apr 2013, In: Bioorganic and Medicinal Chemistry. 21, 7, p. 2107-2116 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility

Siedlinski, M., Tingley, D., Lipman, P. J., Cho, M. H., Litonjua, A. A., Sparrow, D., Bakke, P., Gulsvik, A., Lomas, D. A., Anderson, W., Kong, X., Rennard, S. I., Beaty, T. H., Hokanson, J. E., Crapo, J. D., Lange, C., Silverman, E. K., COPDGene and ECLIPSE Investigators & Macnee, B., Apr 2013, In: Human Genetics. 132, 4, p. 431-41 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Systematic Review and Meta-Analysis of Haemostatic and Biliostatic Efficacy of Fibrin Sealants in Elective Liver Surgery

Sanjay, P., Watt, D. G. & Wigmore, S. J., Apr 2013, In: Journal of Gastrointestinal Surgery. 17, 4

Research output: Contribution to journal › Article › peer-review

Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

Gray, R. D., Lucas, C., Mackellar, A., Li, F., Hiersemenzel, K., Haslett, C., Davidson, D. J. & Rossi, A. G., 21 Mar 2013, In: Journal of inflammation. 10, 1, 8 p., 12.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cardiovascular disease in COPD: mechanisms

Maclay, J. D. & MacNee, W., Mar 2013, In: Chest Journal. 143, 3, p. 798-807 10 p.

Research output: Contribution to journal › Article › peer-review

Combination peptide immunotherapy based on T cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation

Mackenzie, K. J., Fitch, P. M., Leech, M. D., Ilchmann, A., Wilson, C., McFarlane, A., Howie, S. E., Anderton, S. M. & Schwarze, J., Mar 2013, In: Immunology . 138, 3, p. 258-268 11 p.

Research output: Contribution to journal › Article › peer-review

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

Lucas, C., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R. & Rossi, A. G., Mar 2013, In: The FASEB Journal. 27, 3, p. 1084-1094 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Nanoparticles and the cardiovascular system: a critical review

Donaldson, K., Duffin, R., Langrish, J. P., Miller, M. R., Mills, N. L., Poland, C. A., Raftis, J., Shah, A., Shaw, C. A. & Newby, D. E., Mar 2013, In: Nanomedicine. 8, 3, p. 403-423 21 p.

Research output: Contribution to journal › Article › peer-review

Six-Minute-Walk Test in Chronic Obstructive Pulmonary Disease: Minimal Clinically Important Difference for Death or Hospitalization

Evaluation COPD Longitudinally Ide, Polkey, M. I., Spruit, M. A., Edwards, L. D., Watkins, M. L., Pinto-Plata, V., Vestbo, J., Calverley, P. M. A., Tal-Singer, R., Agusti, A., Bakke, P. S., Coxson, H. O., Lomas, D. A., MacNee, W., Rennard, S., Silverman, E. K., Miller, B. E., Crim, C., Yates, J. & Wouters, E. F. M. & 1 others, Celli, B., 15 Feb 2013, In: American Journal of Respiratory and Critical Care Medicine. 187, 4, p. 382-386 5 p.

Research output: Contribution to journal › Article › peer-review

Cutting Edge: IL-6-Dependent Autoimmune Disease: Dendritic Cells as a Sufficient, but Transient, Source

Leech, M. D., Barr, T. A., Turner, D. G., Brown, S., O'Connor, R. A., Gray, D., Mellanby, R. J. & Anderton, S. M., 1 Feb 2013, In: The Journal of Immunology. 190, 3, p. 881-885 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre

Bellamy, C. O. C., Maxwell, R. S., Prost, S., Azodo, I. A., Powell, J. J. & Manning, J., Feb 2013, In: Histopathology. 62, 3, p. 431-445 15 p.

Research output: Contribution to journal › Article › peer-review

Histologic Assessment of Tumor-Associated CD45+ Cell Numbers Is an Independent Predictor of Prognosis in Small Cell Lung CancerSmall Cell Lung Cancer: CD45+ Cells and Outcome

Wang, W., Hodkinson, P., McLaren, F., Mackean, M. J., Williams, L., Howie, S. E. M., Wallace, W., Sethi, T., Williams, L. & Mackean, M. J., Jan 2013, In: Chest Journal. 143, 1, p. 146-151 6 p.

Research output: Contribution to journal › Article › peer-review

Innate recognition of apoptotic cells: novel apoptotic cell-associated molecular patterns revealed by crossreactivity of anti-LPS antibodies

Tennant, I., Pound, J. D., Marr, L. A., Willems, J. J. L. P., Petrova, S., Ford, C. A., Paterson, M., Devitt, A. & Gregory, C. D., 2013, In: Cell Death & Differentiation (CDD). 20, 5

Research output: Contribution to journal › Article › peer-review

Multicomponent Reactions for de Novo Synthesis of BODIPY Probes: In vivo Imaging of Phagocytic Macrophages

Vazquez-Romero, A. M., Kielland, N., Arevalo, M. J., Preciado, S., Mellanby, R., Feng, Y., Lavilla, R. & Vendrell, M., 2013, In: Journal of the American Chemical Society. 135, 43, p. 16018–16021

Research output: Contribution to journal › Article › peer-review

Phosphoinositide 3-OH Kinase Regulates Integrin-Dependent Processes in Neutrophils by Signaling through Its Effector ARAP3

Gambardella, L., Anderson, K. E., Jakus, Z., Kovács, M., Voigt, S., Hawkins, P. T., Stephens, L., Mócsai, A. & Vermeren, S., 2013, In: The Journal of Immunology. 190, 1, p. 381-91 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The involvement of xanthohumol in the expression of annexin in human malignant glioblastoma cells

Festa, M., Caputo, M., Cipolla, C., D'Acunto, C., Rossi, A., Tecce, M. & Capasso, A., 2013, In: The Open Biochemistry Journal. 7, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The Uncoupling of Monocyte-Platelet Interactions from the Induction of Proinflammatory Signaling in Monocytes

Stephen, J., Emerson, B., Fox, K. A. A. & Dransfield, I., 2013, In: The Journal of Immunology.

Research output: Contribution to journal › Article › peer-review

2012

Diesel Exhaust Particle Exposure In Vitro Alters Monocyte Differentiation and Function

Chaudhuri, N., Jary, H., Lea, S., Khan, N., Piddock, K. C., Dockrell, D., Donaldson, K., Duffin, R., Singh, D., Parker, L. C. & Sabroe, I., 7 Dec 2012, In: PLoS ONE. 7, 12, 12 p., ARTN e51107.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

Leitch, A. E., Lucas, C., Marwick, J. A., Duffin, R., Haslett, C. & Rossi, A. G., Dec 2012, In: Cell Death & Differentiation (CDD). 19, 12, p. 1950-1961 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Differential effects of long and short carbon nanotubes on the gas-exchange region of the mouse lung

Mühlfeld, C., Poland, C. A., Duffin, R., Brandenberger, C., Murphy, F. A., Rothen-Rutishauser, B., Gehr, P. & Donaldson, K., Dec 2012, In: Nanotoxicology. 6, 8, p. 867-879 13 p.

Research output: Contribution to journal › Article › peer-review

Factors associated with prophylactic plasma transfusion before vascular catheterization in non-bleeding critically ill adults with prolonged prothrombin time: a casecontrol study

Intensive Care Study Coagulopathy, Hall, D. P., Lone, N. I., Watson, D. M., Stanworth, S. J. & Walsh, T. S., Dec 2012, In: British Journal of Anaesthesia. 109, 6, p. 919-927 9 p.

Research output: Contribution to journal › Article › peer-review

Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity

Poland, C. A., Byrne, F., Cho, W.-S., Prina-Mello, A., Murphy, F. A., Davies, G. L., Coey, J. M. D., Gounko, Y., Duffin, R., Volkov, Y. & Donaldson, K., Dec 2012, In: Nanotoxicology. 6, 8, p. 899-911 13 p.

Research output: Contribution to journal › Article › peer-review

Ventilator-Associated Pneumonia Is Characterized by Excessive Release of Neutrophil Proteases in the Lung

Wilkinson, T. S., Conway-Morris, A., Kefala, K., O'Kane, C. M., Moore, N. R., Booth, N. A., McAuley, D. F., Dhaliwal, K., Walsh, T. S., Haslett, C., Sallenave, J.-M. & Simpson, A. J., Dec 2012, In: Chest Journal. 142, 6, p. 1425-1432 8 p.

Research output: Contribution to journal › Article › peer-review

Pure populations of murine macrophages from cultured embryonic stem cells. Application to studies of chemotaxis and apoptotic cell clearance

Zhuang, L., Pound, J. D., Willems, J. J. L. P., Taylor, A. H., Forrester, L. M. & Gregory, C. D., 30 Nov 2012, In: Journal of Immunological Methods. 385, 1-2, p. 1-14 14 p.

Research output: Contribution to journal › Article › peer-review

Bone attenuation on routine chest CT correlates with bone mineral density on DXA in patients with COPD

Romme, E. A. P. M., Murchison, J. T., Phang, K. F., Jansen, F. H., Rutten, E. P. A., Wouters, E. F. M., Smeenk, F. W. J. M., Van Beek, E. J. R. & Macnee, W., Nov 2012, In: Journal of Bone and Mineral Research. 27, 11, p. 2338-2343 6 p.

Research output: Contribution to journal › Article › peer-review

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial

Treweeke, A. T., Winterburn, T. J., Mackenzie, I., Barrett, F., Barr, C., Rushworth, G. F., Dransfield, I., MacRury, S. M. & Megson, I. L., Nov 2012, In: Diabetologia. 55, 11, p. 2920-2928 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD

Ubhi, B. K., Cheng, K. K., Dong, J., Janowitz, T., Jodrell, D., Tal-Singer, R., MacNee, W., Lomas, D. A., Riley, J. H., Griffin, J. L. & Connor, S. C., 30 Oct 2012, In: Molecular BioSystems. 8, 12, p. 3125-33 9 p.

Research output: Contribution to journal › Article › peer-review

TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

Mellanby, R. J., Cambrook, H., Turner, D., O'Connor, R. A., Leech, M. D., Kurschus, F. C., Macdonald, A. S., Arnold, B. & Anderton, S. M., 30 Oct 2012, In: Journal of Neuroinflammation. 9, 1, 248.

Research output: Contribution to journal › Article › peer-review

Open Access

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Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice

Ferenbach, D. A., Sheldrake, T. A., Dhaliwal, K., Kipari, T. M. J., Marson, L. P., Kluth, D. C. & Hughes, J., Oct 2012, In: Kidney International. 82, 8, p. 928-933 6 p.

Research output: Contribution to journal › Article › peer-review

Neuromuscular electrical stimulation prevents muscle function deterioration in exacerbated COPD: A pilot study

Giavedoni, S., Deans, A., McCaughey, P., Drost, E., MacNee, W. & Rabinovich, R. A., Oct 2012, In: Respiratory Medicine. 106, 10, p. 1429-1434 6 p.

Research output: Contribution to journal › Article › peer-review

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

Research output

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