Research output per year
Research output per year
- 1 - 50 out of 101 results
Search results
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2024
xiVIEW: Visualisation of Crosslinking Mass Spectrometry Data
Combe, C. W., Graham, M., Kolbowski, L., Fischer, L. & Rappsilber, J., 1 Sept 2024, In: Journal of Molecular Biology. 436, 17, 10 p., 168656.Research output: Contribution to journal › Article › peer-review
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C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
Zoch, A., Konieczny, G., Auchynnikava, T., Stallmeyer, B., Rotte, N., Heep, M., Berrens, R. V., Schito, M., Kabayama, Y., Schöpp, T., Kliesch, S., Houston, B., Nagirnaja, L., O’Bryan, M. K., Aston, K. I., Conrad, D. F., Rappsilber, J., Allshire, R. C., Cook, A. G., Tüttelmann, F., & 1 others, 21 Mar 2024, In: Molecular Cell. 84, 6, p. 1021 27 p.Research output: Contribution to journal › Article › peer-review
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2023
Higher‐order modular regulation of the human proteome
Kustatscher, G., Hödl, M., Rullmann, E., Grabowski, P., Fiagbedzi, E., Groth, A. & Rappsilber, J., 9 May 2023, In: Molecular Systems Biology. 19, 5, 14 p., e9503.Research output: Contribution to journal › Article › peer-review
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2022
Visualizing translation dynamics at atomic detail inside a bacterial cell
Xue, L., Lenz, S., Zimmermann-Kogadeeva, M., Tegunov, D., Cramer, P., Bork, P., Rappsilber, J. & Mahamid, J., 28 Sept 2022, (E-pub ahead of print) In: Nature. 610, 7930, p. 205-211 7 p.Research output: Contribution to journal › Article › peer-review
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Generation of glycan-specific nanobodies
Khilji, S. K., Goerdeler, F., Frensemeier, K., Warschkau, D., Lühle, J., Fandi, Z., Schirmeister, F., Chen, Z. A., Turak, O., Mallagaray, A., Boerno, S., Timmermann, B., Rappsilber, J., Seeberger, P. H. & Moscovitz, O., 18 Aug 2022, In: Cell Chemical Biology. 29, 8, p. 1353-1361.e6 9 p.Research output: Contribution to journal › Article › peer-review
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Improved peptide backbone fragmentation is the primary advantage of MS-cleavable crosslinkers
Kolbowski, L., Lenz, S., Fischer, L., Sinn, L., O'Reilly, F. J. & Rappsilber, J., 7 Jun 2022, In: Analytical Chemistry. 94, 22, p. 7779-7786 8 p.Research output: Contribution to journal › Article › peer-review
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Leveraging parameter dependencies in high-field asymmetric waveform ion-mobility spectrometry and size-exclusion chromatography for proteome-wide crosslinking mass spectrometry
Sinn, L. R., Giese, S. H., Stuiver, M. & Rappsilber, J., 11 Mar 2022, In: Analytical Chemistry. 94, 11, p. 4627-4634 8 p.Research output: Contribution to journal › Article › peer-review
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Leveraging crosslinking mass spectrometry in structural and cell biology
Graziadei, A. & Rappsilber, J., 6 Jan 2022, In: Structure. 30, 1, p. 37-54 18 p.Research output: Contribution to journal › Review article › peer-review
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2021
A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination
Staneva, D., Carloni, R., Auchynnikava, T., Tong, P., Rappsilber, J., Jeyaprakash, A. A., Matthews, K. R. & Allshire, R. C., 1 Nov 2021, In: Genome Research. 31, 11, p. 2138-2154 17 p.Research output: Contribution to journal › Article › peer-review
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STING Nuclear Partners Contribute to Innate Immune Signalling Responses
Dixon, C., Malik, P., de las Heras, J., Saiz ros, N., Alves, F. L., Tingey, M., Gaunt, E., Richardson, A. C., Kelly, D., Goldberg, M., Towers, G. J., Yang, W., Rappsilber, J., Digard, P. & Schirmer, E. C., 28 Aug 2021, (E-pub ahead of print) In: iScience. 103055.Research output: Contribution to journal › Article › peer-review
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Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses
Banchenko, S., Krupp, F., Gotthold, C., Bürger, J., Graziadei, A., O'Reilly, F. J., Sinn, L., Ruda, O., Rappsilber, J., Spahn, C. M. T., Mielke, T., Taylor, I. A. & Schwefel, D., 2 Aug 2021, In: PLoS Pathogens. 17, 8, 34 p., e1009775.Research output: Contribution to journal › Article › peer-review
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DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network
Hammond, C. M., Bao, H., Hendriks, I. A., Carraro, M., García-Nieto, A., Liu, Y., Reverón-Gómez, N., Spanos, C., Chen, L., Rappsilber, J., Nielsen, M. L., Patel, D. J., Huang, H. & Groth, A., 17 Jun 2021, In: Molecular Cell. 81, 12, p. 2533-2548.e9 16 p.Research output: Contribution to journal › Article › peer-review
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Reliable identification of protein-protein interactions by crosslinking mass spectrometry
Lenz, S., Sinn, L., O'Reilly, F. J., Fischer, L., Wegner, F. & Rappsilber, J., 11 Jun 2021, In: Nature Communications. 12, 11 p., 3564.Research output: Contribution to journal › Article › peer-review
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Retention time prediction using neural networks increases identifications in crosslinking mass spectrometry
Giese, S. H., Sinn, L., Wegner, F. & Rappsilber, J., 28 May 2021, In: Nature Communications. 12, 34 p., 3237.Research output: Contribution to journal › Article › peer-review
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SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase
Su, B., Wang, M., Schaffner, C., Nerusheva, O. O., Clift, D., Spanos, C., Kelly, D., Tatham, M. H., Wallek, A., Wu, Y., Rappsilber, J., Jeyaprakash, A. A., Storchova, Z., Hay, R. T. & Marston, A. L., 30 Apr 2021, In: Journal of Cell Biology. 220, 7, 25 p., e202005130.Research output: Contribution to journal › Article › peer-review
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Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end
Lau, C. K., O’Reilly, F. J., Santhanam, B., Lacey, S. E., Rappsilber, J. & Carter, A. P., 18 Mar 2021, In: EMBO Journal. 40, 8, 19 p., e106164.Research output: Contribution to journal › Article › peer-review
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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
Nakamura, K., Kustatscher, G., Alabert, C., Hödl, M., Forne, I., Völker-Albert, M., Satpathy, S., Beyer, T. E., Mailand, N., Choudhary, C., Imhof, A., Rappsilber, J. & Groth, A., 4 Mar 2021, In: Molecular Cell. 81, 5, p. P1084-1099.E6 16 p.Research output: Contribution to journal › Article › peer-review
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Shulin packages axonemal outer dynein arms for ciliary targeting
Mali, G. R., Ali, F. A., Lau, C. K., Begum, F., Boulanger, J., Howe, J. D., Chen, Z. A., Rappsilber, J., Skehel, M. & Carter, A. P., 26 Feb 2021, In: Science. 371, 6532, p. 910-916 7 p., abe0526.Research output: Contribution to journal › Article › peer-review
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Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts
Kyrilis, F. L., Semchonok, D. A., Skalidis, I., Tüting, C., Hamdi, F., O’Reilly, F. J., Rappsilber, J. & Kastritis, P. L., 9 Feb 2021, In: Cell Reports. 34, 6, 108727.Research output: Contribution to journal › Article › peer-review
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The proteomic landscape of centromeric chromatin reveals an essential role for the Ctf19CCAN complex in meiotic kinetochore assembly
Borek, W., Vincenten, N., Duro, E., Makrantoni, V., Spanos, C., Sarangapani, K. K., de Lima Alves, F., Kelly, D., Asbury, C. L., Rappsilber, J. & Marston, A. L., 25 Jan 2021, In: Current Biology. 31, 2, p. P283-296.E7 14 p.Research output: Contribution to journal › Article › peer-review
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Isolation of acetylated and unmodified protein N-Terminal peptides by strong cation exchange chromatographic separation of TrypN-digested peptides
Chang, C-H., Chang, H-Y., Rappsilber, J. & Ishihama, Y., 1 Jan 2021, In: Molecular & Cellular Proteomics (MCP). 20, 9 p., 100003.Research output: Contribution to journal › Article › peer-review
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2020
The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling
Pei, H-H., Hilal, T., Chen, Z. A., Huang, Y-H., Gao, Y., Said, N., Loll, B., Rappsilber, J., Belogurov, G. A., Artsimovitch, I. & Wahl, M. C., 18 Dec 2020, In: Nature Communications. 11, 1, 14 p., 6418.Research output: Contribution to journal › Article › peer-review
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Megadalton-sized dityrosine aggregates of α-synuclein retain high degrees of structural disorder and internal dynamics
Verzini, S., Shah, M., Theillet, F-X., Belsom, A., Bieschke, J., Wanker, E. E., Rappsilber, J., Binolfi, A. & Selenko, P., 4 Dec 2020, In: Journal of Molecular Biology. 432, 24, 16 p., 166689.Research output: Contribution to journal › Article › peer-review
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Multiomics analysis provides insight into the laboratory evolution of Escherichia coli towards the metabolic usage of fluorinated indoles
Agostini, F., Sinn, L., Petras, D., Schipp, C. J., Kubyshkin, V., Berger, A. A., Dorrestein, P. C., Rappsilber, J., Budisa, N. & Koksch, B., 20 Nov 2020, (E-pub ahead of print) In: ACS Central Science. 12 p.Research output: Contribution to journal › Article › peer-review
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Stress-induced translation inhibition through rapid displacement of scanning initiation factors
Bresson, S., Shchepachev, V., Spanos, C., Turowski, T., Rappsilber, J. & Tollervey, D., 5 Nov 2020, In: Molecular Cell. 80, 3, p. 470-484.e8 15 p.Research output: Contribution to journal › Article › peer-review
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Towards increased reliability, transparency and accessibility in crosslinking mass spectrometry
Leitner, A., Bonvin, A. M. J. J., Borchers, C. H., Chalkley, R. J., Chamot-Rooke, J., Combe, C., Cox, J., Dong, M-Q., Fischer, L., Götze, M., Gozzo, F. C., Heck, A. J. R., Hoopmann, M. R., Huang, L., Ishihama, Y., Jones, A. R., Kalisman, N., Kohlbacher, O., Mechtler, K., Moritz, R. L., & 16 others, 3 Nov 2020, In: Structure. 28, 11, p. 1259-1268 10 p.Research output: Contribution to journal › Article › peer-review
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A structure-based mechanism for DNA entry into the cohesin ring
Higashi, T. L., Eickhoff, P., Sousa, J. S., Locke, J., Nans, A., Flynn, H. R., Snijders, A. P., Papageorgiou, G., O’reilly, N., Chen, Z. A., O’Reilly, F. J., Rappsilber, J., Costa, A. & Uhlmann, F., 17 Sept 2020, In: Molecular Cell. 79, 6, p. 917-933.e9 17 p.Research output: Contribution to journal › Article › peer-review
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SPOCD1 is an essential executor of piRNA-directed 1 de novo DNA methylation
Zoch, A., Auchynnikava, T., Berrens, R. V., Kabayama, Y., Schöpp, T., Heep, M., Vasiliauskaitė, L., Pérez-Rico, Y. A., Cook, A. G., Shkumatava, A., Rappsilber, J., Allshire, R. C. & O'Carroll, D., 27 Aug 2020, In: Nature. 584, 7822, p. 635-639 5 p.Research output: Contribution to journal › Article › peer-review
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The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment
Legal, T., Hayward, D., Gluszek-Kustusz, A., Blackburn, E., Spanos, C., Rappsilber, J., Gruneberg, U. & Welburn, J. P. I., 25 Aug 2020, In: Journal of Cell Science. 133, 16, 11 p., jcs246025.Research output: Contribution to journal › Article › peer-review
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Anatomy of a crosslinker
Belsom, A. & Rappsilber, J., 21 Aug 2020, (E-pub ahead of print) In: Current opinion in chemical biology. 60, p. 39-46Research output: Contribution to journal › Article › peer-review
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In-cell architecture of an actively transcribing-translating expressome
O'Reilly, F. J., Xue, L., Graziadei, A., Sinn, L., Lenz, S., Tegunov, D., Blötz, C., Singh, N., Hagen, W. J. H., Cramer, P., Stülke, J., Mahamid, J. & Rappsilber, J., 31 Jul 2020, In: Science. 369, 6503, p. 554-557 4 p.Research output: Contribution to journal › Article › peer-review
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TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing
Schöpp, T., Zoch, A., Berrens, R. V., Auchynnikava, T., Kabayama, Y., Vasiliauskaitė, L., Rappsilber, J., Allshire, R. C. & O'Carroll, D., 27 Jul 2020, (E-pub ahead of print) In: Nature Communications. 11, 3739.Research output: Contribution to journal › Article › peer-review
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The arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2
Bloomer, R. H., Hutchison, C. E., Bäurle, I., Walker, J., Fang, X., Perera, P., Velanis, C. N., Gümüs, S., Spanos, C., Rappsilber, J., Feng, X., Goodrich, J. & Dean, C., 14 Jul 2020, In: Proceedings of the National Academy of Sciences (PNAS). 117, 28, p. 16660-16666 7 p.Research output: Contribution to journal › Article › peer-review
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Proteomics using protease alternatives to trypsin benefits from sequential digestion with trypsin
Dau, T., Bartolomucci, G. & Rappsilber, J., 6 Jul 2020, (E-pub ahead of print) In: Analytical Chemistry.Research output: Contribution to journal › Article › peer-review
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Substrate specificity of the TRAMP nuclear surveillance complexes
Delan-Forino, C., Spanos, C., Rappsilber, J. & Tollervey, D., 19 Jun 2020, In: Nature. 11, 3122.Research output: Contribution to journal › Article › peer-review
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Microtubule nucleation properties of single human γTuRCs explained by their Cryo-EM structure
Consolati, T., Locke, J., Roostalu, J., Chen, Z. A., Gannon, J., Asthana, J., Lim, W. M., Martino, F., Cvetkovic, M. A., Rappsilber, J., Costa, A. & Surrey, T., 19 May 2020, (E-pub ahead of print) In: Developmental Cell. 53, 5, p. 603-617.e8Research output: Contribution to journal › Article › peer-review
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Ultraviolet photodissociation of tryptic peptide backbones at 213 nm
Kolbowski, L., Belsom, A. & Rappsilber, J., 30 Apr 2020, (E-pub ahead of print) In: Journal of the American Society for Mass Spectrometry. 31, 6, p. 1282-1290Research output: Contribution to journal › Article › peer-review
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The structure of human thyroglobulin
Coscia, F., Taler-Verčič, A., Chang, V. T., Sinn, L., O’Reilly, F. J., Izoré, T., Renko, M., Berger, I., Rappsilber, J., Turk, D. & Löwe, J., 27 Feb 2020, In: Nature. 578, 7796, p. 627-630 4 p.Research output: Contribution to journal › Article › peer-review
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A protocol for studying structural dynamics of proteins by quantitative crosslinking mass spectrometry and data-independent acquisition
Müller, F. & Rappsilber, J., 25 Feb 2020, In: Journal of proteomics. 218, 103721.Research output: Contribution to journal › Article › peer-review
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Hap2–Ino80-facilitated transcription promotes de novo establishment of CENP-A chromatin
Singh, P. P., Shukla, M., White, S. A., Lafos, M., Tong, P., Auchynnikava, T., Spanos, C., Rappsilber, J., Pidoux, A. L. & Allshire, R. C., 9 Jan 2020, (E-pub ahead of print) In: Genes & Development. 34, 3-4, p. 226-238Research output: Contribution to journal › Article › peer-review
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In situ structural restraints from cross-linking mass spectrometry in human Mitochondria
Ryl, P. S. J., Bohlke-schneider, M., Lenz, S., Fischer, L., Budzinski, L., Stuiver, M., Mendes, M. M. L., Sinn, L., O’reilly, F. J. & Rappsilber, J., 3 Jan 2020, In: Journal Of Proteome Research. 19, 1, p. 327-336Research output: Contribution to journal › Article › peer-review
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2019
The structure and oxidation of the eye lens chaperone αA-crystallin
Kaiser, C. J. O., Peters, C., Schmid, P. W. N., Stavropoulou, M., Zou, J., Dahiya, V., Mymrikov, E. V., Rockel, B., Asami, S., Haslbeck, M., Rappsilber, J., Reif, B., Zacharias, M., Buchner, J. & Weinkauf, S., 2 Dec 2019, In: Nature Structural and Molecular Biology. 26, 12, p. 1141-1150 10 p.Research output: Contribution to journal › Article › peer-review
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Structure of the fanconi anaemia monoubiquitin ligase complex
Shakeel, S., Rajendral, E., Alcón, P., O’Reilly, F. J., Chorev, D. S., Maslen, S., Degliesposti, G., Russo, C. J., He, S., Hill, C. H., Skehel, J. M., Scheres, S. H. W., Patel, K. J., Rappsilber, J., Robinson, C. V. & Passmore, L. A., 30 Oct 2019, In: Nature. 575, p. 234-237Research output: Contribution to journal › Article › peer-review
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An integrated workflow for crosslinking mass spectrometry
Mendes, M. L., Fischer, L., Chen, Z. A., Barbon, M., O'Reilly, F. J., Giese, S. H., Bohlke-Schneider, M., Belsom, A., Dau, T., Combe, C. W., Graham, M., Eisele, M. R., Baumeister, W., Speck, C. & Rappsilber, J., 20 Sept 2019, In: Molecular Systems Biology. 15, 9, e8994.Research output: Contribution to journal › Article › peer-review
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Quantitative photo-crosslinking mass spectrometry revealing protein structure response to environmental changes
Müller, F., Graziadei, A. & Rappsilber, J., 16 Jul 2019, In: Analytical Chemistry. 91, 14, p. 9041-9048 8 p.Research output: Contribution to journal › Article › peer-review
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Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity
Makarov, A. A., Zou, J., Houston, D. R., Spanos, C., Solovyova, A. S., Cardenal-Peralta, C., Rappsilber, J. & Schirmer, E. C., 11 Jul 2019, In: Nature Communications. 10, 1, 17 p., 3056.Research output: Contribution to journal › Article › peer-review
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Reductional meiosis I chromosome segregation is established by coordination of key meiotic kinases
Galander, S., Barton, R., Borek, W. E., Spanos, C., Kelly, D. A., Robertson, D., Rappsilber, J. & Marston, A. L., 20 May 2019, In: Developmental Cell. 49, 4, p. 526-541.e5 22 p.Research output: Contribution to journal › Article › peer-review
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The Molecular Basis of Monopolin Recruitment to the Kinetochore
Plowman, R., Singh, N., Tromer, E., Payan, A., Duro, E., Spanos, C., Rappsilber, J., Snel, B., Kops, G. J. P. L., Corbett, K. D. & Marston, A. L., 30 Apr 2019, (E-pub ahead of print) In: Chromosoma. 24 p.Research output: Contribution to journal › Article › peer-review
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Defining the RNA interactome by total RNA-associated protein purification
Shchepachev, V., Bresson, S., Spanos, C., Petfalski, E., Fischer, L., Rappsilber, J. & Tollervey, D., 8 Apr 2019, In: Molecular Systems Biology. 15, 4, 23 p., e8689.Research output: Contribution to journal › Article › peer-review
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Sequential digestion with Trypsin and Elastase in cross-linking mass spectrometry
Dau, T., Gupta, K., Berger, I. & Rappsilber, J., 2 Apr 2019, In: Analytical Chemistry. 91, p. 4472-4478 7 p.Research output: Contribution to journal › Article › peer-review
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