Proteomic analysis of deafferentation-induced plasticity in medial vestibular nucleus and cerebellum.

  • Dutia, Mayank (Principal Investigator)
  • Aitken, Alastair (Co-investigator)

Project Details

Key findings

This research idenfied key proteins in the brain which are associated with the recovery of behavioural function after unilateral vestibular damage, in the process known as "vestibular compensation" (VC). In man vestibular lesions lead to sometimes chronic dizziness and vertigo, with a substantial negative impact on the quality of life of the affected patients. This research for the first time implicated specific proteins associated with changes in metabolic energy demands, neuronal outgrowth and synaptic remodelling in VC. The findings suggest novel roles for axon elaboration and guidance molecules, as well as mitochondrial and metabolic regulatory proteins in the functional recovery, and provide a new basis for understanding VC at the molecular level.
StatusFinished
Effective start/end date1/04/0431/03/07

Funding

  • BBSRC: £248,607.00