RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Research output

Research output per year 2012 2013 2014 2015 2016 2017 2018 2023

• 507 Article
• 5 Meeting abstract
• 5 Literature review
• 2 Editorial
• 4 More
  • 1 Conference contribution
  • 1 Comment/debate
  • 1 Short survey
  • 1 Special issue

Research output per year

Research output per year

Search results

• 2023

  The contributions of mitochondrial and nuclear mitochondrial genetic variation to neuroticism

  Xia, C., Pickett, S. J., Liewald, D. C. M., Weiss, A., Hudson, G. & Hill, W. D., May 2023, In: Nature Communications. 14, 1, 3146 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mutation 100%
  • Mitochondrial Genetics 100%
  • Neuroticism 100%
  • Haplogroup 100%
  • Genetic Variation 100%

• Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936

  Clancy, U., Radakovic, R., Doubal, F., Hernández, M. D. C. V., Maniega, S. M., Taylor, A. M., Corley, J., Chappell, F. M., Russ, T. C., Cox, S. R., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Jan 2023, In: International Journal of Geriatric Psychiatry. 38, 1, e5855.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • White Matter 100%
  • Symptom 100%
  • Marker 100%
  • Small Vessel Disease 100%
  • Disease Exacerbation 100%
• 2022

  What determines cognitive estimation ability? Changing contributions of semantic and executive domains as a function of age

  Hoffman, P. & MacPherson, S. E., Sept 2022, In: Journal of Neuropsychology. 16, 3, p. 481-497

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Domains 100%
  • Functions 100%
  • Semantics 100%
  • Abilities 100%
  • Test Performance 83%

• Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

  Mishra, A., Duplaà, C., Vojinovic, D., Suzuki, H., Sargurupremraj, M., Zilhão, N. R., Li, S., Bartz, T. M., Jian, X., Zhao, W., Hofer, E., Wittfeld, K., Harris, S. E., van der Auwera-Palitschka, S., Luciano, M., Bis, J. C., Adams, H. H. H., Satizabal, C. L., Gottesman, R. F., Gampawar, P. G., & 47 othersBülow, R., Weiss, S., Yu, M., Bastin, M. E., Lopez, O. L., Vernooij, M. W., Beiser, A. S., Völker, U., Kacprowski, T., Soumare, A., Smith, J. A., Knopman, D. S., Morris, Z., Zhu, Y., Rotter, J. I., Dufouil, C., Valdés Hernández, M., Muñoz Maniega, S., Lathrop, M., Boerwinkle, E., Schmidt, R., Ihara, M., Mazoyer, B., Yang, Q., Joutel, A., Tournier-Lasserve, E., Launer, L. J., Deary, I. J., Mosley, T. H., Amouyel, P., DeCarli, C. S., Psaty, B. M., Tzourio, C., Kardia, S. L. R., Grabe, H. J., Teumer, A., van Duijn, C. M., Schmidt, H., Wardlaw, J. M., Ikram, M. A., Fornage, M., Gudnason, V., Seshadri, S., Matthews, P. M., Longstreth, W. T., Couffinhal, T. & Debette, S., 2 May 2022, (E-pub ahead of print) In: Brain. awab432.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cerebrovascular Disease 100%
  • Gene Map 100%
  • Gene Mapping 100%
  • Association 85%
  • Small Vessel Disease 71%
• 2020

  Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects

  Ballerini, L., McGrory, S., Valdes Hernandez, M., Lovreglio, R., Pellegrini, E., MacGillivray, T., Muñoz Maniega, S., Henderson, R., Taylor, A., Bastin, M., Doubal, F., Trucco, E., Deary, I. & Wardlaw, J., 21 Aug 2020, In: Cerebral Circulation—Cognition and Behavior. 1, 100002.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brain 100%
  • Measurement 100%
  • Perivascular Space 100%
  • Morphology 36%
  • Age 27%

• Blood pressure and cognitive function across the eighth decade: A prospective study of the Lothian Birth Cohort 1936

  Altschul, D., Starr, J. & Deary, I., 23 Jul 2020, (E-pub ahead of print) In: BMJ Open.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Prospective Study 100%
  • Blood Pressure 100%
  • Cognition 100%
  • Cognitive Function 100%
  • Childbirth 100%

• Playing analog games is associated with reduced declines in cognitive function: A 68 year longitudinal cohort study

  Altschul, D. & Deary, I., Mar 2020, In: The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences. 75, 3, p. 474-482

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Cognitive Decline 16%
  • Abilities 5%
  • Behavior 5%
  • Goals 5%

• A new look at neuroticism: Should we worry so much about worrying?

  Weiss, A. & Deary, I., 2020, In: Current Directions in Psychological Science. 29, 1, p. 92-101

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Worry 100%
  • Neuroticism 100%
  • Groups 33%
  • Personality 33%
  • Physical Health 33%
• 2019

  How youth cognitive and sociodemographic factors relate to the development of overweight and obesity in the UK and the USA: a prospective cross-cohort study of the National Child Development Study and National Longitudinal Study of Youth 1979

  Altschul, D., Wraw, C., Gale, C. & Deary, I., 17 Dec 2019, In: BMJ Open. 9, 12, e033011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Longitudinal Analysis 100%
  • Sociodemographic Factors 100%
  • Sociodemographics 100%
  • Child Development 100%
  • Obesity 100%

• The role of neuroticism in self-harm and suicidal ideation: Results from two UK population-based cohorts

  Hafferty, J. D., Navrady, L. B., Adams, M. J., Howard, D. M., Campbell, A. I., Whalley, H. C., Lawrie, S. M., Nicodemus, K. K., Porteous, D. J., Deary, I. J. & Mcintosh, A. M., Dec 2019, In: Social psychiatry and psychiatric epidemiology. 54, 12, p. 1505-1518

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuroticism 100%
  • Automutilation 100%
  • Suicidal Ideation 100%
  • Coping 87%
  • Emotion 50%

• Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

  Clarke, T-K., Adams, M. J., Howard, D. M., Xia, C., Davies, G., Hayward, C., Campbell, A., Padmanabhan, S., Smith, B. H., Murray, A., Porteous, D., Deary, I. J. & Mcintosh, A. M., 25 Nov 2019, (E-pub ahead of print) In: Molecular Psychiatry. N/A, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetics 100%
  • Smoking 100%
  • Substance Abuse 100%
  • Alcohol Abuse 100%
  • Substance Use 50%

• Longitudinal associations between loneliness and cognitive ability in the Lothian Birth Cohort 1936: 1376-1386

  Okely, J. A. & Deary, I. J., Nov 2019, In: The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences. 74, 8, p. 1376-1386 gby086.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Loneliness 100%
  • Abilities 25%
  • Processing Speed 25%
  • Visuospatial Ability 25%

• Divergent effects of healthy ageing on semantic knowledge and control: Evidence from novel comparisons with semantically-impaired patients

  Hoffman, P., Sept 2019, In: Journal of Neuropsychology. 13, 3, p. 462-484

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Semantics 100%
  • Healthy Aging 100%
  • Semantic Knowledge 100%
  • Groups 50%
  • Cognition 33%

• What do older people do when sitting and why? Implications for decreasing sedentary behavior

  USP Team, Aug 2019, In: Gerontologist. 59, 4, p. 686-697 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Older Adult 100%
  • Older People 100%
  • Sedentary Behavior 100%
  • Leisure Activity 60%
  • Woman 40%

• Where words meet numbers: Comprehension of measurement unit terms in posterior cortical atrophy

  Suárez González, A., Hoffman, P. & Crutch, S., Aug 2019, In: Neuropsychologia. 131, p. 216-222

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Measurement 100%
  • Comprehension 100%
  • Brain 40%
  • Semantics 20%
  • Abilities 20%

• Individual differences in cognitive processes underlying Trail Making Test-B performance in old age: The Lothian Birth Cohort 1936

  MacPherson, S. E., Allerhand, M., Cox, S. R. & Deary, I. J., Jul 2019, In: Intelligence. 75, p. 23-32

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Process 100%
  • Individual Differences 100%
  • Trail Making Test 100%
  • Processing Speed 57%
  • Cognitive Factor 28%

• Reaction time variability and brain white matter integrity

  Booth, T., Dykiert, D., Corley, J., Gow, A., Morrison, Z., Munoz-Maniega, S., Royle, N., Valdes Hernandez, M., Starr, J., Penke, L., Bastin, M., Wardlaw, J. & Deary, I., 28 Jun 2019, In: Neuropsychology. 33, 5, p. 642-657

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brain 100%
  • White Matter 100%
  • Reaction Time 100%
  • Individual Differences 25%
  • Magnetic Resonance Imaging of Brain 12%

• What genome-wide association studies reveal about the association between intelligence and physical health, illness, and mortality

  Deary, I. J., Harris, S. E. & Hill, W. D., 1 Jun 2019, In: Current Opinion in Psychology. 27, p. 6-12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Association 100%
  • Mortality 100%
  • Intelligence 100%
  • Health 100%

• Insulin resistance: Genetic associations with depression and cognition in population based cohorts

  Frangou, S., Shirali, M., Adams, M. J., Howard, D. M., Gibson, J., Hall, L. S., Smith, B. H., Padmanabhan, S., Murray, A. D., Porteous, D. J., Haley, C. S., Deary, I. J., Clarke, T. & Mcintosh, A. M., Jun 2019, In: Experimental neurology. 316, p. 20-26

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognition 100%
  • Insulin Resistance 100%
  • Genetic Association 100%
  • Insulin 100%
  • Depression 100%

• What genome-wide association studies reveal about the association between intelligence and mental health

  Hill, W. D., Harris, S. E. & Deary, I. J., Jun 2019, In: Current Opinion in Psychology. 27, p. 25-30

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Association 100%
  • Mental Health 100%
  • Genome Wide Association Study 100%
  • Intelligence 100%
  • Genome-Wide Association Study 100%

• Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

  Grotzinger, A., Rhemtulla, M., Vlaming, R. D., Ritchie, S. J., Mallard, T. T., Hill, W. D., Hill, F., Marioni, R., McIntosh, A., Deary, I., Koellinger, P. D., Harden, K. P., Nivard, M. G. & Tucker-Drob, E. M., May 2019, In: Nature Human Behaviour. 3, 5, p. 513-525

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Structural Equation Modeling 100%
  • Genome-Wide Association Study 100%
  • Introspection 100%
  • Genetic Architecture 100%
  • Scanning Electron Microscopy 75%

• Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: A meta-analysis

  Marini, S., Crawford, K., Morotti, A., Lee, M. J., Pezzini, A., Moomaw, C. J., Flaherty, M. L., Montaner, J., Roquer, J., Jimenez-conde, J., Giralt-steinhauer, E., Elosua, R., Cuadrado-godia, E., Soriano-tarraga, C., Slowik, A., Jagiella, J. M., Pera, J., Urbanik, A., Pichler, A., Hansen, B. M., & 32 othersMccauley, J. L., Tirschwell, D. L., Selim, M., Brown, D. L., Silliman, S. L., Worrall, B. B., Meschia, J. F., Kidwell, C. S., Testai, F. D., Kittner, S. J., Schmidt, H., Enzinger, C., Deary, I. J., Rannikmae, K., Samarasekera, N., Salman, R. A., Sudlow, C. L., Klijn, C. J. M., Van Nieuwenhuizen, K. M., Fernandez-cadenas, I., Delgado, P., Norrving, B., Lindgren, A., Goldstein, J. N., Viswanathan, A., Greenberg, S. M., Falcone, G. J., Biffi, A., Langefeld, C. D., Woo, D., Rosand, J. & Anderson, C. D., 1 Apr 2019, In: JAMA Neurology. p. 480-491

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Race 100%
  • Ethnicity 100%
  • Intracerebral Hemorrhage 100%
  • Apolipoprotein E 100%
  • Meta-Analysis 100%

• Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

  Howard, D. M., Adams, M. J., Clarke, T-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., Alloza, C., Shen, X., Barbu, M. C., Xu, E. Y., Whalley, H. C., Marioni, R. E., Porteous, D. J., Davies, G., Deary, I. J., Hemani, G., & 20 othersBerger, K., Teismann, H., Rawal, R., Arolt, V., Baune, B. T., Dannlowski, U., Domschke, K., Tian, C., Hinds, D. A., 23andMe Research Team, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Trzaskowski, M., Byrne, E. M., Ripke, S., Smith, D. J., Sullivan, P. F., Wray, N. R., Breen, G., Lewis, C. M. & McIntosh, A. M., 31 Mar 2019, In: Nature Neuroscience. 22, 3, p. 343–352 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brain 100%
  • Meta-Analysis 100%
  • Depression 100%
  • Gene 60%
  • Genome-Wide Association Study 20%

• Aluminium and fluoride in drinking water in relation to later dementia risk

  Russ, T., Killin, L., Hannah, J., Batty, G. D., Deary, I. & Starr, J., 14 Mar 2019, (E-pub ahead of print) In: The British Journal of Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dementia 100%
  • Fluoride 100%
  • Water 100%
  • Aluminum 100%
  • Fluorine 16%

• An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

  Hamilton, O., Zhang, Q., Mcrae, A. F., Walker, R., Morris, S., Redmond, P., Campbell, A., Murray, A., Porteous, D., Evans, K., McIntosh, A., Deary, I. & Marioni, R., 6 Mar 2019, In: International Journal of Obesity.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Birth 100%
  • Body Mass 100%
  • DNA Methylation 100%
  • Health 100%

• Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

  Prendergast, J., Pugh, C., Harris, S., Hume, D., Deary, I. & Beveridge, A., Mar 2019, In: Genome Biology and Evolution. 11, 3, p. 759–775

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mutation 100%
  • Population Differentiation 100%
  • Evolution 100%
  • Single-Nucleotide Polymorphism 100%
  • Protein 100%

• A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence

  Hill, W. D., Marioni, R. E., Maghzian, O., Ritchie, S. J., Hagenaars, S. P., McIntosh, A. M., Gale, C. R., Davies, G. & Deary, I. J., 28 Feb 2019, In: Molecular Psychiatry. 24, 2, p. 169-181 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Intelligence 100%
  • Myelination 100%
  • Nervous System Development 100%
  • Myelinogenesis 100%
  • Neurogenesis 100%

• Hypertension development by midlife and the roles of pre-morbid cognition function, sex, and their interaction

  Altschul, D., Wraw, C., Der, G., Gale, C. & Deary, I., 19 Feb 2019, In: Hypertension. 73, 4, p. 812–819

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hypertension 100%
  • Cognition 100%
  • Cognitive Function 100%
  • Socioeconomic Status 25%
  • Family Income 12%

• Cognitive ability and risk of death from lower respiratory tract infection: Findings from UK Biobank

  Gale, C., Deary, I. & Batty, G. D., 4 Feb 2019, In: Scientific Reports.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lower Respiratory Tract Infection 100%
  • Death 100%
  • Cognitive Function 100%
  • Lower Respiratory Tract 100%
  • Respiratory Tract 100%

• Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

  Olova, N., Simpson, D. J., Marioni, R. E. & Chandra, T., 1 Feb 2019, In: Aging Cell. 18, 1, e12877.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Identity 100%
  • Reprogramming 100%
  • Age 100%
  • Somatic 100%

• The neurobiology of personal control during reward learning and its relation to mood

  Romaniuk, L., Sandu, A., Waiter, G. D., Mcneil, C. J., Xueyi, S., Harris, M. A., Macfarlane, J. A., Lawrie, S. M., Deary, I. J., Murray, A. D., Delgado, M. R., Steele, J. D., Mcintosh, A. M. & Whalley, H. C., Feb 2019, In: Biological psychiatry. Cognitive neuroscience and neuroimaging. 4, 2, p. 190-199 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Reinforcement Learning 100%
  • Behavior (Neuroscience) 100%
  • Neuroscience 100%
  • Anhedonia 50%
  • Frontal Lobe 50%

• Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP

  Wigmore, E., Hafferty, J., Hall, L., Howard, D. M., Clarke, T-K., Fabbri, C., Lewis, C. M., Uher, R., Navrady, L., Adams, M. J., Zeng, Y., Campbell, A., Gibson, J., Thomson, P., Hayward, C., Smith, B. H., Hocking, L. J., Padmanabhan, S., Deary, I., Porteous, D., & 4 othersMors, O., Mattheisen, M., Nicodemus, K. & McIntosh, A., 31 Jan 2019, In: Pharmacogenomics Journal.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Therapeutic Procedure 100%
  • Meta-Analysis 100%
  • Antidepressant 100%
  • Health Service 100%
  • Genome Wide Association Study 100%

• Reductions in prefrontal activation predict off-topic utterances during speech production

  Hoffman, P., 31 Jan 2019, In: Nature Communications. 10, 11 p., 515.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Prefrontal Cortex 100%
  • Functional Magnetic Resonance Imaging 100%
  • Neural System 50%
  • Communication 50%
  • Behavior (Neuroscience) 50%

• Positive and negative well-being and objectively measured sedentary behaviour in older adults: Evidence from three cohorts

  Seniors USP Team, Okely, J., Čukić, I., Shaw, R. J., Chastin, S. F. M., Dall, P. M., Deary, I. J., Der, G., Dontje, M. L., Skelton, D. A. & Gale, C., 30 Jan 2019, (E-pub ahead of print) In: BMC Geriatrics. 19, 28, 28.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Depression 100%
  • Sedentary Behavior 100%
  • Anxiety 100%
  • Wellbeing 100%
  • Regression Analysis 20%

• Sex-specific moderation by lifestyle and psychosocial factors on the genetic contributions to adiposity in 112,151 individuals from UK Biobank

  Calvin, C., Hagenaars, S., Gallacher, J., Harris, S., Davies, G., Liewald, D., Gale, C. & Deary, I., 23 Jan 2019, In: Scientific Reports. 9, 363.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Obesity 100%
  • Psychosocial Factor 100%
  • Lifestyle 100%
  • Biobank 100%
  • Moderation 100%

• Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

  Kilpeläinen, T. O., Bentley, A. R., Noordam, R., Ju Sung, Y., Harris, S., Schwander, K., Porteous, D., Starr, J. & Deary, I., 22 Jan 2019, In: Nature Communications. p. 1-11 376 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Blood Lipids 100%
  • Physical Activity 100%
  • Cholesterol 60%
  • LHX1 60%
  • Lipid Level 40%

• Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

  Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R. D., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S., Boehnke, M., & 156 othersBots, M. L., Brazel, D. M., Chambers, J. C., Chang-claude, J., Chen, C., Corley, J., Chou, Y., David, S. P., De Boer, R. A., De Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A., Hsu, C., Iacono, W. G., Kanoni, S., Kapoor, M., Kaprio, J., Kardia, S. L., Karpe, F., Kontto, J., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Laakso, M., Lai, D., Langenberg, C., Le, N., Lettre, G., Loukola, A., Luan, J., Madden, P. A. F., Mangino, M., Marioni, R. E., Marouli, E., Marten, J., Martin, N. G., Mcgue, M., Michailidou, K., Mihailov, E., Moayyeri, A., Moitry, M., Müller-nurasyid, M., Naheed, A., Nauck, M., Neville, M. J., Nielsen, S. F., North, K., Perola, M., Pharoah, P. D. P., Pistis, G., Polderman, T. J., Posthuma, D., Poulter, N., Qaiser, B., Rasheed, A., Reiner, A., Renström, F., Rice, J., Rohde, R., Rolandsson, O., Samani, N. J., Samuel, M., Schlessinger, D., Scholte, S. H., Scott, R. A., Sever, P., Shao, Y., Shrine, N., Smith, J. A., Starr, J. M., Stirrups, K., Stram, D., Stringham, H. M., Tachmazidou, I., Tardif, J., Thompson, D. J., Tindle, H. A., Tragante, V., Trompet, S., Turcot, V., Tyrrell, J., Vaartjes, I., Van Der Leij, A. R., Van Der Meer, P., Varga, T. V., Verweij, N., Völzke, H., Wareham, N. J., Warren, H. R., Weir, D. R., Weiss, S., Wetherill, L., Yaghootkar, H., Yavas, E., Jiang, Y., Chen, F., Zhan, X., Zhang, W., Zhao, W., Zhao, W., Zhou, K., Amouyel, P., Blankenberg, S., Caulfield, M. J., Chowdhury, R., Cucca, F., Deary, I. J., Deloukas, P., Di Angelantonio, E., Ferrario, M., Ferrières, J., Franks, P. W., Frayling, T. M., Frossard, P., Hall, I. P., Hayward, C., Jansson, J., Jukema, J. W., Kee, F., Männistö, S., Metspalu, A., Munroe, P. B., Nordestgaard, B. G., Palmer, C. N. A., Salomaa, V., Sattar, N., Spector, T., Strachan, D. P., Van Der Harst, P., Zeggini, E., Saleheen, D., Butterworth, A. S., Wain, L. V., Abecasis, G. R., Danesh, J., Tobin, M. D., Vrieze, S., Liu, D. J. & Howson, J. M. M., 7 Jan 2019, (E-pub ahead of print) In: Molecular Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene Locus 100%
  • Smoking 100%
  • Single-Nucleotide Polymorphism 80%
  • Association 30%
  • Sample 10%

• Associations of mitochondrial and nuclear mitochondrial variants and genes with seven metabolic traits

  Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-gao, R., Hartwig, F. P., Lin, S. J., Wang, L., & 132 othersRichardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., Van Heemst, D., De Las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., De Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K., Love-gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., De Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-pedersen, C., Stergiakouli, E., Sheu, W. H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., De Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3 Jan 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Association 100%
  • Nested Gene 100%
  • Mitochondrion 100%
  • Mitochondrial DNA 50%
  • Body Mass 40%

• Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and white matter microstructure in UK Biobank

  Barbu, M. C., Zeng, Y., Shen, X., Cox, S. R., Clarke, T., Gibson, J., Adams, M. J., Johnstone, M., Haley, C. S., Lawrie, S. M., Deary, I. J., Mcintosh, A. M. & Whalley, H. C., 1 Jan 2019, In: Biological psychiatry. Cognitive neuroscience and neuroimaging. 4, 1, p. 91-100 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • White Matter 100%
  • Association 100%
  • Major Depressive Episode 100%
  • Signal Transduction 100%
  • Cell Signaling 100%

• Tracking the epigenetic clock across the human life course: A meta-analysis of longitudinal cohort data

  Marioni, R., Suderman, M. J., Chen, B. H., Horvath, S., Bandinelli, S., Morris, T. J., Becker, S., Ferrucci, L., Pedersen, N. L., Relton, C. L., Deary, I. & Hägg, S., Jan 2019, In: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. 74, 1, p. 1-5 gly060.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clock 100%
  • Meta-Analysis 100%
  • Datum 100%
  • Epigenetics 100%
  • Life 100%

• Conditioning on a collider may or may not explain the relationship between lower neuroticism and premature mortality in Gale et al. (2017): A reply to Richardson, Davey Smith, and Munafó (2018)

  Weiss, A., Gale, C., Čukić, I., Batty, G. D., McIntosh, A. & Deary, I., 2019, In: Psychological Science. 30, 4, p. 633-638

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Neuroticism 100%
  • Self-Rated Health 80%
  • Health 40%
  • Conditioning 20%
  • Worry 20%

• Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

  Chauhan, G., Adams, H. H. H., Satizabal, C. L., Bis, J. C., Teumer, A., Sargurupremraj, M., Hofer, E., Trompet, S., Hilal, S., Smith, A. V., Jian, X., Malik, R., Traylor, M., Pulit, S. L., Amouyel, P., Mazoyer, B., Zhu, Y., Kaffashian, S., Schilling, S., Beecham, G. W., & 130 othersMontine, T. J., Schellenberg, G. D., Kjartansson, O., Guðnason, V., Knopman, D. S., Griswold, M. E., Windham, B. G., Gottesman, R. F., Mosley, T. H., Schmidt, R., Saba, Y., Schmidt, H., Takeuchi, F., Yamaguchi, S., Nabika, T., Kato, N., Rajan, K. B., Aggarwal, N. T., De Jager, P. L., Evans, D. A., Psaty, B. M., Rotter, J. I., Rice, K., Lopez, O. L., Liao, J., Chen, C., Cheng, C., Wong, T. Y., Ikram, M. K., Van Der Lee, S. J., Amin, N., Chouraki, V., Destefano, A. L., Aparicio, H. J., Romero, J. R., Maillard, P., Decarli, C., Wardlaw, J. M., Hernández, M. D. C. V., Luciano, M., Liewald, D., Deary, I. J., Starr, J. M., Bastin, M. E., Muñoz Maniega, S., Slagboom, P. E., Beekman, M., Deelen, J., Uh, H., Lemmens, R., Brodaty, H., Wright, M. J., Ames, D., Boncoraglio, G. B., Hopewell, J. C., Beecham, A. H., Blanton, S. H., Wright, C. B., Sacco, R. L., Wen, W., Thalamuthu, A., Armstrong, N. J., Chong, E., Schofield, P. R., Kwok, J. B., Van Der Grond, J., Stott, D. J., Ford, I., Jukema, J. W., Vernooij, M. W., Hofman, A., Uitterlinden, A. G., Van Der Lugt, A., Wittfeld, K., Grabe, H. J., Hosten, N., Von Sarnowski, B., Völker, U., Levi, C., Jimenez-conde, J., Sharma, P., Sudlow, C. L. M., Rosand, J., Woo, D., Cole, J. W., Meschia, J. F., Slowik, A., Thijs, V., Lindgren, A., Melander, O., Grewal, R. P., Rundek, T., Rexrode, K., Rothwell, P. M., Arnett, D. K., Jern, C., Johnson, J. A., Benavente, O. R., Wasssertheil-smoller, S., Lee, J., Wong, Q., Mitchell, B. D., Rich, S. S., Mcardle, P. F., Geerlings, M. I., Van Der Graaf, Y., De Bakker, P. I. W., Asselbergs, F. W., Srikanth, V., Thomson, R., Mcwhirter, R., Moran, C., Callisaya, M., Phan, T., Rutten-jacobs, L. C. A., Bevan, S., Tzourio, C., Mather, K. A., Sachdev, P. S., Van Duijn, C. M., Worrall, B. B., Dichgans, M., Kittner, S. J., Markus, H. S., Ikram, M. A., Fornage, M., Launer, L. J., Seshadri, S., Longstreth, W. T. & Debette, S., 2019, In: Neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lifestyle 100%
  • Magnetic Resonance Imaging 100%
  • Brain Infarction 100%
  • Brain 100%
  • Blood Pressure 33%

• New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

  Shrine, N. R. G., Guyatt, A., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C., Batini, C., Fawcett, K. A., Song, K., Sakornsakolpat, P., Li, X., Boxall, R., Reeve, N. F., Obeidat, M., Zhao, J. H., Wielscher, M., Understanding Society Scientific Group, Weiss, S., Kentistou, K., Cook, J. P., & 88 othersSun, B. B., Zhou, J., Hui, J., Karrasch, S., Imboden, M., Harris, S., Marten, J., Enroth, S., Kerr, S., Surakka, I., Vitart, V., Lehtimäki, T., Allen, R. J., Bakke, P. S., Beaty, T. H., Bleecker, E. R., Bossé, Y., Brandsma, C-A., Chen, Z., Crapo, J. D., Danesh, J., Demeo, D. L., Dudbridge, F., Ewert, R., Gieger, C., Gulsvik, A., Hansell, A. L., Hao, K., Hoffman, J. D., Hokanson, J. E., Homuth, G., Joshi, P., Joubert, P., Langenberg, C., Li, X., Li, L., Lin, K., Lind, L., Locantore, N., Luan, J., Mahajan, A., Maranville, J. C., Murray, A., Nickle, D. C., Packer, R., Parker, M. M., Paynton, M. L., Porteous, D., Prokopenko, D., Qiao, D., Rawal, R., Runz, H., Sayers, I., Sin, D. D., Smith, B. H., Soler Artigas, M., Sparrow, D., Tal-Singer, R., Timmers, P. RHJ., van den Berge, M., Woodruff, P. G., Yerges-Armstrong, L. M., Troyanskaya, O. G., Raitakar, O. ., Kähönen, M., Polasek, O., Rudan, I., Deary, I., Probst-Hensch, N. M., Schulz, H., James, A. L., Wilson, J. F., Stubbe, B., Zeggini, E., Jarvelin, M-R., Wareham, N., Silverman, E. K., Hayward, C., Morris, A. P., Butterworth, A. S., Scott, R. A., Walters, R. G., Meyers, D. A., Cho, M. H., Strachan, D. P., Hall, I. P., Tobin, M. D. & Wain, L. V., 2019, In: Nature Genetics. 51, p. 481–493

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Obstructive Pulmonary Disease 100%
  • Lung 100%
  • Disease Association 100%
  • Pleiotropy 100%
  • Association 100%
• 2018

  Genomic analysis of family data reveals additional genetic effects on intelligence and personality

  Hill, W. D., Arslan, R. C., Xia, C., Luciano, M., Amador, C., Navarro, P., Hayward, C., Nagy, R., Porteous, D. J., McIntosh, A. M., Deary, I. J., Haley, C. S. & Penke, L., 31 Dec 2018, In: Molecular Psychiatry. 23, 12, p. 2347–2362 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Personality 100%
  • Intelligence 100%
  • Genetic Determinism 100%
  • Genetic Divergence 57%
  • Single-Nucleotide Polymorphism 42%

• Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study

  Alloza, C., Cox, S. R., Blesa Cábez, M., Redmond, P., Whalley, H. C., Ritchie, S. J., Muñoz Maniega, S., del C Valdés Hernández, M., Tucker-Drob, E. M., Lawrie, S. M., Wardlaw, J. M., Deary, I. J. & Bastin, M. E., 31 Dec 2018, In: NeuroImage. 183, p. 884-896 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dementia Praecox 100%
  • Tractography 100%
  • Brain 100%
  • Fractional Anisotropy 33%
  • Splenium 16%

• Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

  Stevenson, A., McCartney, D. L., Harris, S., Taylor, A., Redmond, P., Starr, J., Zhang, Q., McRae, A. F., Wray, N. R., Spires-Jones, T., McColl, B., McIntosh, A., Deary, I. & Marioni, R., 20 Dec 2018, In: Clinical Epigenetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Immunocompetent Cell 100%
  • Association 100%
  • Aging 100%
  • Age 100%

• Identification of 55,000 Replicated DNA Methylation QTL

  McRae, A. F., Marioni, R. E., Shah, S., Yang, J., Powell, J. E., Harris, S. E., Gibson, J., Henders, A. K., Bowdler, L., Painter, J. N., Murphy, L., Martin, N. G., Starr, J. M., Wray, N. R., Deary, I. J., Visscher, P. M. & Montgomery, G. W., 4 Dec 2018, In: Scientific Reports. 8, 1, p. 1-9 17605.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quantitative Trait Locus 100%
  • DNA Methylation 100%
  • Methylation 100%
  • Single Nucleotide Polymorphism 80%
  • Genetics 40%

• GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

  Franceschini, N., Giambartolomei, C., De Vries, P. S., Finan, C., Bis, J. C., Huntley, R. P., Lovering, R. C., Tajuddin, S. M., Winkler, T. W., Graff, M., Kavousi, M., Dale, C., Smith, A. V., Hofer, E., Van Leeuwen, E. M., Nolte, I. M., Lu, L., Scholz, M., Sargurupremraj, M., Pitkänen, N., & 137 othersFranzén, O., Joshi, P. K., Noordam, R., Marioni, R. E., Hwang, S., Musani, S. K., Schminke, U., Palmas, W., Isaacs, A., Correa, A., Zonderman, A. B., Hofman, A., Teumer, A., Cox, A. J., Uitterlinden, A. G., Wong, A., Smit, A. J., Newman, A. B., Britton, A., Ruusalepp, A., Sennblad, B., Hedblad, B., Pasaniuc, B., Penninx, B. W., Langefeld, C. D., Wassel, C. L., Tzourio, C., Fava, C., Baldassarre, D., O’leary, D. H., Teupser, D., Kuh, D., Tremoli, E., Mannarino, E., Grossi, E., Boerwinkle, E., Schadt, E. E., Ingelsson, E., Veglia, F., Rivadeneira, F., Beutner, F., Chauhan, G., Heiss, G., Snieder, H., Campbell, H., Völzke, H., Markus, H. S., Deary, I. J., Jukema, J. W., De Graaf, J., Price, J., Pott, J., Hopewell, J. C., Liang, J., Thiery, J., Engmann, J., Gertow, K., Rice, K., Taylor, K. D., Dhana, K., Kiemeney, L. A. L. M., Lind, L., Raffield, L. M., Launer, L. J., Holdt, L. M., Dörr, M., Dichgans, M., Traylor, M., Sitzer, M., Kumari, M., Kivimaki, M., Nalls, M. A., Melander, O., Raitakari, O., Franco, O. H., Rueda-ochoa, O. L., Roussos, P., Whincup, P. H., Amouyel, P., Giral, P., Anugu, P., Wong, Q., Malik, R., Rauramaa, R., Burkhardt, R., Hardy, R., Schmidt, R., De Mutsert, R., Morris, R. W., Strawbridge, R. J., Wannamethee, S. G., Hägg, S., Shah, S., Mclachlan, S., Trompet, S., Seshadri, S., Kurl, S., Heckbert, S. R., Ring, S., Harris, T. B., Lehtimäki, T., Galesloot, T. E., Shah, T., De Faire, U., Plagnol, V., Rosamond, W. D., Post, W., Zhu, X., Zhang, X., Guo, X., Saba, Y., Dehghan, A., Seldenrijk, A., Morrison, A. C., Hamsten, A., Psaty, B. M., Van Duijn, C. M., Lawlor, D. A., Mook-kanamori, D. O., Bowden, D. W., Schmidt, H., Wilson, J. G., Rotter, J. I., Wardlaw, J. M., Deanfield, J., Halcox, J., Lyytikäinen, L., Loeffler, M., Evans, M. K., Debette, S., Humphries, S. E., Völker, U., Gudnason, V., Hingorani, A. D., Björkegren, J. L. M., Casas, J. P. & O’donnell, C. J., 3 Dec 2018, In: Nature Communications. 9, 1, 5141.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Plaque 100%
  • Intima-Media Thickness 100%
  • Cardiovascular System 100%
  • Genome Wide Association Study 100%
  • Carotid Artery 83%

• Fluid intelligence predicts change in depressive symptoms in later life: The Lothian Birth Cohort 1936

  Aichele, S., Ghisletta, P., Corley, J., Pattie, A., Taylor, A., Starr, J. M. & Deary, I. J., 1 Dec 2018, In: Psychological Science. 29, 12, p. 1984-1995

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fluid Intelligence 100%
  • Cognitive Performance 25%
  • Depression 25%
  • Health 25%

• Systematic comparative validation of self-report measures of sedentary time against an objective measure of postural sitting (activPAL)

  Chastin, S. F. M., Dontje, M. L., Skelton, D. A., Čukić, I., Shaw, R. J., Gill, J. M. R., Greig, C. A., Gale, C. R., Deary, I. J., Der, G. & Dall, P. M., 1 Dec 2018, In: International Journal of Behavioral Nutrition and Physical Activity. 15, 21, 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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