Role of Ubiquitin-Protein Ligase UBR5 in Gastrointestinal Cancer

  • Ditzel, Mark (Principal Investigator)
  • Sansom, Owen J (Co-investigator)

Project Details


Our novel conditional UBR5 mutant mouse has revealed a tumour suppressor role in oncogenic K-Ras driven gastrointestinal cancer. Based upon our molecular analysis, we hypothesise that UBR5 influences intestinal stem cell function through regulating the activity of the Hedgehog and Wnt signal transduction pathways. In collaboration with Prof Sansom (Deputy Director of the CRUK Beatson Institute) we aim to use a combination of mouse genetics, primary cell culture, transcriptomics and proteomics to address our hypothesis.

Key findings

UBR5 acts as a tumour suppressor in oncogenic K-Ras-driven gastrointestinal cancer.
UBR5 regulates both Hedgehog and Wnt signal transdction.
Effective start/end date1/01/151/01/19


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