Role of Ubiquitin-Protein Ligase UBR5 in Pancreatic Cancer

  • Ditzel, Mark (Principal Investigator)
  • Sansom, Owen J (Co-investigator)

Project Details


Our novel conditional UBR5 mutant mouse has revealed a tumour suppressor role in oncogenic K-Ras driven pancreatic cancer. Based upon our molecular analysis, we hypothesise that UBR5 influences islet cell function through regulating the activity of the Hedgehog and Wnt signal transduction pathways. In collaboration with Prof Sansom (Deputy Director of the CRUK Beatson Institute) we aim to use a combination of mouse genetics, primary cell culture, transcriptomics and proteomics to address our hypothesis.

Key findings

UBR5 suppresses oncogenic K-Ras driven pancreatic tumourigenesis.
UBR5 regulates Hedgehog and Wnt signal transduction.
Effective start/end date1/01/151/01/18


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