The Disconnected Mind Phase 3

2021

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

De Las Fuentes, L., Sung, Y. J., Noordam, R., Winkler, T., Feitosa, M. F., Schwander, K., Bentley, A. R., Brown, M. R., Guo, X., Manning, A., Chasman, D. I., Aschard, H., Bartz, T. M., Bielak, L. F., Campbell, A., Cheng, C., Dorajoo, R., Hartwig, F. P., Horimoto, A. R. V. R., Li, C., & 202 othersLi-gao, R., Liu, Y., Marten, J., Musani, S. K., Ntalla, I., Rankinen, T., Richard, M., Sim, X., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Vojinovic, D., Warren, H. R., Xuan, D., Alver, M., Boissel, M., Chai, J., Chen, X., Christensen, K., Divers, J., Evangelou, E., Gao, C., Girotto, G., Harris, S. E., He, M., Hsu, F., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Rueedi, R., Shu, X., Snieder, H., Sofer, T., Takeuchi, F., Verweij, N., Ware, E. B., Weiss, S., Yanek, L. R., Amin, N., Arking, D. E., Arnett, D. K., Bergmann, S., Boerwinkle, E., Brody, J. A., Broeckel, U., Brumat, M., Burke, G., Cabrera, C. P., Canouil, M., Chee, M. L., Chen, Y. I., Cocca, M., Connell, J., De Silva, H. J., De Vries, P. S., Eiriksdottir, G., Faul, J. D., Fisher, V., Forrester, T., Fox, E. F., Friedlander, Y., Gao, H., Gigante, B., Giulianini, F., Gu, C. C., Gu, D., Harris, T. B., He, J., Heikkinen, S., Heng, C., Hunt, S., Ikram, M. A., Irvin, M. R., Kähönen, M., Kavousi, M., Khor, C. C., Kilpeläinen, T. O., Koh, W., Komulainen, P., Kraja, A. T., Krieger, J. E., Langefeld, C. D., Li, Y., Liang, J., Liewald, D. C. M., Liu, C., Liu, J., Lohman, K. K., Mägi, R., Mckenzie, C. A., Meitinger, T., Metspalu, A., Milaneschi, Y., Milani, L., Mook-kanamori, D. O., Nalls, M. A., Nelson, C. P., Norris, J. M., O’connell, J., Ogunniyi, A., Padmanabhan, S., Palmer, N. D., Pedersen, N. L., Perls, T., Peters, A., Petersmann, A., Peyser, P. A., Polasek, O., Porteous, D. J., Raffel, L. J., Rice, T. K., Rotter, J. I., Rudan, I., Rueda-ochoa, O., Sabanayagam, C., Salako, B. L., Schreiner, P. J., Shikany, J. M., Sidney, S. S., Sims, M., Sitlani, C. M., Smith, J. A., Starr, J. M., Strauch, K., Swertz, M. A., Teumer, A., Tham, Y. C., Uitterlinden, A. G., Vaidya, D., Van Der Ende, M. Y., Waldenberger, M., Wang, L., Wang, Y., Wei, W., Weir, D. R., Wen, W., Yao, J., Yu, B., Yu, C., Yuan, J., Zhao, W., Zonderman, A. B., Becker, D. M., Bowden, D. W., Deary, I. J., Dörr, M., Esko, T., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Jonas, J. B., Kammerer, C. M., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., Marques-vidal, P., Penninx, B. W. J. H., Samani, N. J., Van Der Harst, P., Wagenknecht, L. E., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Cooper, R. S., Correa, A., Evans, M. K., Gudnason, V., Hayward, C., Horta, B. L., Kelly, T. N., Kritchevsky, S. B., Levy, D., Palmas, W. R., Pereira, A. C., Province, M. M., Psaty, B. M., Ridker, P. M., Rotimi, C. N., Tai, E. S., Van Dam, R. M., Van Duijn, C. M., Wong, T. Y., Rice, K., Gauderman, W. J., Morrison, A. C., North, K. E., Kardia, S. L. R., Caulfield, M. J., Elliott, P., Munroe, P. B., Franks, P. W., Rao, D. C. & Fornage, M., Jun 2021, In: Molecular Psychiatry. 26, p. 2111–2125

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life

Hill, W. D., Weiss, A., Liewald, D. C., Davies, G., Porteous, D. J., Hayward, C., McIntosh, A., Gale, C. R. & Deary, I. J., 30 Nov 2020, In: Molecular Psychiatry. 25, p. 3034–3052 19 p.

Research output: Contribution to journal › Article › peer-review

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Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

Stevenson, A., McCartney, D., Hillary, R., Campbell, A., Morris, S., Bermingham, M., Walker, R., Evans, K. L., Boutin, T., Hayward, C., Mcrae, A. F., McColl, B., Spires-Jones, T., McIntosh, A., Deary, I. & Marioni, R. E., 27 Jul 2020, In: Clinical Epigenetics. 12, 113.

Research output: Contribution to journal › Article › peer-review

Open Access

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Blood pressure and cognitive function across the eighth decade: A prospective study of the Lothian Birth Cohort 1936

Altschul, D., Starr, J. & Deary, I., 23 Jul 2020, (E-pub ahead of print) In: BMJ Open.

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Is healthy neuroticism associated with chronic conditions? A coordinated integrative data analysis

Weston, S. J., Graham, E. K., Turiano, N. A., Aschwanden, D., Booth, T., Harrison, F., James, B. D., Lewis, N. A., Makkar, S. R., Mueller, S., Wisniewski, K. M., Yoneda, T. B., Zhaoyang, R., Spiro, A., Drewelies, J., Wagner, G. G., Steinhagen-Thiessen, E., Demuth, I., Willis, S., Schaie, K. W., & 17 othersSliwinski, M., Lipton, R., Katz, M. J., Deary, I., Zelinski, E. M., Bennett, D. A., Sachdev, P. S., Brodaty, H., Trollor, J. N., Ames, D., Wright, M. J., Gerstorf, D., Allemand, M., Terrera, GM., Piccinin, A., Hofer, S. M. & Mroczek, D. K., 21 Jul 2020, (E-pub ahead of print) In: Collabra.

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Open Access

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Is healthy neuroticism associated with health behaviors? A coordinated integrative data analysis

Graham, E. K., Weston, S. J., Turiano, N. A., Aschwanden, D., Booth, T., Harrison, F., James, B. D., Lewis, N. A., Makkar, S. R., Mueller, S., Wisniewski, K. M., Yoneda, T. B., Zhaoyang, R., Spiro, A., Willis, S., Schaie, K. W., Sliwinski, M., Lipton, R., Katz, M. J., Deary, I., & 15 othersZelinski, E. M., Bennett, D. A., Sachdev, P. S., Brodaty, H., Troller, J., Ames, D., Wright, M., Gerstorf, D., Allemand, M., Drewelies, J., Wagner, G. G., Terrera, GM., Piccinin, A. M., Hofer, S. M. & Mroczek, D. K., 21 Jul 2020, In: Collabra.

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Open Access

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Is healthy neuroticism associated with longevity? A coordinated integrative data analysis

Turiano, N. A., Graham, E. K., Weston, S. J., Booth, T., Harrison, F., James, B. D., Lewis, N. A., Makkar, S. R., Mueller, S., Wisniewski, K. M., Zhaoyang, R., Spiro, A., Willis, S., Schaie, K. W., Lipton, R. B., Katz, M. J., Sliwinski, M., Deary, I., Zelinski, E. M., Bennett, D. A., & 10 othersSachdev, P. S., Brodaty, H., Troller, J., Ames, D., Wright, M. J., Gerstorf, D., Terrera, GM., Piccinin, A., Hofer, S. M. & Mroczek, D. K., 21 Jul 2020, In: Collabra.

Research output: Contribution to journal › Article › peer-review

Open Access

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Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults

Hillary, R., Trejo-Banos, D., Kousathanas, A., McCartney, D. L., Harris, S. E., Stevenson, A. J., Patxot, M., Ojavee, S. E., Zhang, Q., Liewald, D. C., Ritchie, C. W., Evans, K. L., Tucker-Drob, E. M., Wray, N. R., McRae, A. F., Visscher, P. M., Deary, I. J., Robinson, M. R. & Marioni, R. E., 8 Jul 2020, In: Genome Medicine. 12, 60.

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Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian 4 Birth Cohort 1936

Toombs, J., Panther, L., Ornelas, L., Liu, C., Gomez, E., Martin-Ibanez, R., Cox, S., Ritchie, S. J., Harris, S., Taylor, A., Redmond, P., Russ, T., Murphy, L., Cooper, J. D., Burr, K., Thangaraj Selvaraj, B., Browne, C., Svendsen, C. N., Cowley, S., Deary, I., & 3 othersChandran, S., Spires-Jones, T. & Sareen, D., 1 Jul 2020, In: Stem Cell Research.

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Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals

Colicino, E., Marioni, R., Ward-Caviness, C., Gondalia, R., Guan, W., Chen, B. H., Tsai, P-C., Huan, T., Xu, G., Agha, G., Schwartz, J., Vokonas, P., Just, A. C., Starr, J., Mcrae, A. F., Wray, N., Visscher, P., Bressler, J., Zhang, W., Toshiko, T., & 29 othersMoore, A. Z., Pilling, L. C., Zhang, G., Stewart, J., Li, Y., Hou, L., Castillo-Fernandez, J., Spector, T. D., Kiel, D. P., Murabito, J. M., Liu, C., Mendelson, M., Assimes, T., Absher, D., Tsaho, P. S., Lu, A. T., Ferrucci, L., Wilson, R. P., Waldenberger, M., Prokisch, H., Bandinelli, S., Bell, J. T., Levy, D., Deary, I., Horvath, S., Pankow, J., Peters, A., Whitsel, E. A. & Baccarelli, A. A., Jul 2020, In: Aging. 12, 14, p. 14092—14124

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Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines

Madole, J. W., Ritchie, S. J., Cox, S. R., Buchanan, C. R., Valdés Hernández, M., Muñoz Maniega, S., Wardlaw, J. M., Harris, M. A. H., Bastin, M. E., Deary, I. J. & Tucker-Drob, E. M., 15 Jun 2020, (E-pub ahead of print) In: Biological Psychiatry. N/A, p. 1-12

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Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality

Ma, J., Rebholz, C. M., Braun, K. V. E., Reynolds, L. M., Aslibekyan, S., Xia, R., Biligowda, N. G., Huan, T., Liu, C., Mendelson, M. M., Joehanes, R., Hu, E. A., Vitolins, M. Z., Wood, A. C., Lohman, K., Ochoa-Rosales, C., van Meurs, J. B. J., Andre Uitterlinden, A. G., Liu, Y., Elhadad, M. A., & 30 othersHeier, M., Waldenberger, M., Peters, A., Colicino, E., Whitsel, E. A., Baldassari, A., Gharib, S. A., Sotoodehnia, N., Brody, J. A., Sitlani, C. M., Tanaka, T., Hill, W. D., Corley, J., Deary, I., Zhang, Y., Schöttker, B., Brenner, H., Walker, M. E., Ye, S., Nguyen, S., Pankow, J., Demerath, E. W., Zheng, Y., Hou, L., Liang, L., Lichtenstein, A. H., Hu, F. B., Fornage, M., Voortman, T. & Levy, D., 11 Jun 2020, (E-pub ahead of print) In: Circulation: Genomic and Precision Medicine.

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Open Access

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Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Armstrong, N. J., Mather, K. A., Sargurupremraj, M., Knol, M. J., Malik, R., Satizabal, C. L., Yanek, L. R., Wen, W., Gudnason, V. G., Dueker, N. D., Elliott, L. T., Hofer, E., Bis, J., Jahanshad, N., Li, S., Logue, M. A., Luciano, M., Scholz, M., Smith, A. V., Trompet, S., & 66 othersVojinovic, D., Xia, R., Alfaro-almagro, F., Ames, D., Amin, N., Amouyel, P., Beiser, A. S., Brodaty, H., Deary, I. J., Fennema-notestine, C., Gampawar, P. G., Gottesman, R., Griffanti, L., Jack, C. R., Jenkinson, M., Jiang, J., Kral, B. G., Kwok, J. B., Lampe, L., C.m. Liewald, D., Maillard, P., Marchini, J., Bastin, M. E., Mazoyer, B., Pirpamer, L., Rafael Romero, J., Roshchupkin, G. V., Schofield, P. R., Schroeter, M. L., Stott, D. J., Thalamuthu, A., Trollor, J., Tzourio, C., Van Der Grond, J., Vernooij, M. W., Witte, V. A., Wright, M. J., Yang, Q., Morris, Z., Siggurdsson, S., Psaty, B., Villringer, A., Schmidt, H., Haberg, A. K., Van Duijn, C. M., Jukema, J. W., Dichgans, M., Sacco, R. L., Wright, C. B., Kremen, W. S., Becker, L. C., Thompson, P. M., Mosley, T. H., Wardlaw, J. M., Ikram, M. A., Adams, H. H. H., Seshadri, S., Sachdev, P. S., Smith, S. M., Launer, L., Longstreth, W., Decarli, C., Schmidt, R., Fornage, M., Debette, S. & Nyquist, P. A., 10 Jun 2020, In: Stroke.

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The long arm of childhood intelligence on terminal decline: Evidence from the Lothian Birth Cohort 1921

Cadar, D., Robitaille, A., Pattie, A., Deary, I. & Terrera, GM., 21 May 2020, (E-pub ahead of print) In: Psychology and Aging. 35, 6, p. 806-817

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Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study

Beaudet, G., Tsuchida, A., Petit, L., Tzourio, C., Caspers, S., Schreiber, J., Pausova, Z., Patel, Y., Paus, T., Schmidt, R., Pirpamer, L., Sachdev, P. S., Brodaty, H., Kochan, N. A., Trollor, J. N., Wen, W., Armstrong, N. J., Deary, I., Bastin, M., Wardlaw, J., & 6 othersMuñoz Maniega, S., Witte, A. V., Villringer, A., Duering, M., Debette, S. & Mazoyer, B., 4 May 2020, In: Frontiers in psychiatry. 11, 342.

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Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples

Li, S., Lund, J. B., Christensen, K., Baumbach, J., Mengel-From, J., Kruse, T. A., Li, W., Mohammadnejad, A., Pattie, A., Marioni, R., Deary, I. & Tan, Q., 28 Apr 2020, In: Genome Medicine. 12, 39.

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DNA methylation in APOE: The relationship with Alzheimer’s and with cardiovascular health

Mur, J., McCartney, D. L., Walker, R., Campbell, A., Bermingham, M., Morris, S., Porteous, D., McIntosh, A., Deary, I., Evans, K. & Marioni, R., 27 Apr 2020, (E-pub ahead of print) In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 6, 1

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Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank

Alloza, C., Blesa-cábez, M., Bastin, M. E., Madole, J. W., Buchanan, C. R., Janssen, J., Gibson, J., Deary, I. J., Tucker-drob, E. M., Whalley, H. C., Arango, C., Mcintosh, A. M., Cox, S. R. & Lawrie, S. M., 27 Apr 2020, In: Translational Psychiatry. 10, 1

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Loss‐of‐function mutations in the ALPL gene presenting with adult onset osteoporosis and low serum concentrations of total alkaline phosphatase

Alonso, N., Larraz‐Prieto, B., Berg, K., Lambert, Z., Redmond, P., Harris, S. E., Deary, I. J., Pugh, C., Prendergast, J. & Ralston, S. H., 8 Apr 2020, In: Journal of Bone and Mineral Research. 35, 4, p. 657-661 4 p.

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DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936

Seeboth, A., McCartney, D. L., Wang, Y., Hillary, R., Stevenson, A., Walker, R., Campbell, A., Evans, K., McIntosh, A., Hägg, S., Deary, I. & Marioni, R., 26 Mar 2020, In: Clinical Epigenetics. 12, 49

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Corticosteroids and regional variations in thickness of the human cerebral cortex across the lifespan

Parker, N., French, L., Vidal-Pineiro, D., Shin, J., Adams, H. H. H., Brodaty, H., Cox, S., Deary, I., Fjell, A. M., Frenzel, S., Grabe, H. J., Hosten, N., Arfan Ikram, M., Jian, J., Knol, M., Mazoyer, B., Mishra, A., Sachdev, P. S., Salum, G., Satizabal, C. L., & 12 othersSchmidt, H., Schmidt, R., Seshadri, S., Schumann, G., Völzke, H., Walhovd, K., Wen, W., Wittfield, K., Yang, Q., Debette, S., Pausova, Z. & Paus, T., 21 Mar 2020, In: Cerebral Cortex. bhz108.

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Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

neuroCHARGE Cognitive Working group & ENIGMA Consortium, 20 Mar 2020, (E-pub ahead of print) In: Cerebral Cortex. bhaa035.

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The genetic architecture of the human cerebral cortex

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group, Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-conde, L., Bralten, J., Hibar, D. P., Lind, P. A., Pizzagalli, F., Ching, C. R. K., Mcmahon, M. A. B., Shatokhina, N., Zsembik, L. C. P., Thomopoulos, S. I., Zhu, A. H., Strike, L. T., Agartz, I., Alhusaini, S., Almeida, M. A. A., Alnæs, D., & 31 othersAmlien, I. K., Andersson, M., Ard, T., Armstrong, N. J., Ashley-koch, A., Atkins, J. R., Bernard, M., Brouwer, R. M., Buimer, E. E. L., Bülow, R., Bürger, C., Cannon, D. M., Chakravarty, M., Chen, Q., Cheung, J. W., Couvy-duchesne, B., Dale, A. M., Dalvie, S., De Araujo, T. K., De Zubicaray, G. I., De Zwarte, S. M. C., Den Braber, A., Doan, N. T., Dohm, K., Ehrlich, S., Harris, M. A., Luciano, M., Wardlaw, J. M., Doherty, C. P., Bastin, M. E. & Deary, I. J., 20 Mar 2020, In: Science. 367, 6484, 14 p., eaay6690.

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Weighted gene co-regulation network analysis (WGCNA) of promoter DNA methylation on all-cause mortality in old-aged birth cohorts finds modules of high-risk associated biomarkers

Lund, J. B., Li, S., Baumbach, J., Christensen, K., Li, W., Mohammadnejad, A., Pattie, A., Marioni, R. E., Deary, I. J. & Tan, Q., 10 Mar 2020, (E-pub ahead of print) In: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences.

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Generational differences in loneliness and its psychological and sociodemographic predictors: An exploratory and confirmatory machine learning study

Altschul, D., Iveson, M. & Deary, I. J., 9 Mar 2020, (E-pub ahead of print) In: Psychological Medicine. N/A, p. 1-10

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Epigenetic age acceleration and cognitive function in African-American adults in midlife: The Atherosclerosis Risk in Communities Study

Bressler, J., Marioni, R. E., Walker, R. M., Xia, R., Gottesman, R. F., Windham, B. G., Grove, M. L., Guan, W., Pankow, J. S., Evans, K. L., Mcintosh, A. M., Deary, I. J., Mosley, T. H., Boerwinkle, E. & Fornage, M., Mar 2020, In: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. 75, 3, p. 473–480 glz245.

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Playing analog games is associated with reduced declines in cognitive function: A 68 year longitudinal cohort study

Altschul, D. & Deary, I., Mar 2020, In: The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences. 75, 3, p. 474-482

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DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: a study of the Lothian Birth Cohort 1921

Sibbett, R. A., Altschul, D. M., Marioni, R. E., Deary, I. J., Starr, J. M. & Russ, T. C., 28 Feb 2020, In: BMC Psychiatry. 20, 1, 91.

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Polygenic architecture of human neuroanatomical diversity

Biton, A., Traut, N., Poline, J. B., Aribsala, B., Bastin, M., Bülow, R., Cox, S., Deary, I., Fukunaga, M., Grabe, H. J., Hagenaars, S., Hashimoto, R., Kikuchi, M., Muñoz Maniega, S., Nauck, M., Royle, N., Teumer, A., Valdes Hernandez, M., Völker, U., Wardlaw, J., & 4 othersWittfield, K., Yamamori, H., Bourgeron, T. & Toro, R., 28 Feb 2020, (E-pub ahead of print) In: Cerebral Cortex. bhz241.

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Education, intelligence and Alzheimer’s disease: Evidence from a multivariable two-sample Mendelian randomization study

Anderson, E. L., Howe, L. D., Wade, K. H., Ben-shlomo, Y., Hill, W. D., Deary, I. J., Sanderson, E. C., Zheng, J., Korologou-Linden, R., Stergiakouli, E., Davey Smith, G., Davies, N. M. & Hemani, G., 31 Jan 2020, (E-pub ahead of print) In: International Journal of Epidemiology. dyz280.

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Open Access

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Fluctuating asymmetry in brain structure and general intelligence in 73-Year-olds

Moodie, J. E., Ritchie, S., Cox, S., Harris, M., Muñoz Maniega, S., Valdes Hernandez, M., Pattie, A., Corley, J., Bastin, M., Starr, J., Wardlaw, J. & Deary, I., 31 Jan 2020, In: Intelligence. 78, 101407.

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Attitudes to ageing, biomarkers of ageing and mortality: The Lothian Birth Cohort 1936

McLachlan, K., Cole, J., Harris, S., Marioni, R., Deary, I. & Gale, C., 28 Jan 2020, (E-pub ahead of print) In: Journal of Epidemiology & Community Health.

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Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalization

Wragg, D., Liu, Q., Lin, Z., Riggio, V., Pugh, C., Beveridge, A., Brown, H., Hume, D., Harris, S., Deary, I., Tenesa, A. & Prendergast, J., 17 Jan 2020, In: Nature Communications. 11, 1, 343.

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Physical frailty and decline in general and specific cognitive abilities: The Lothian Birth Cohort 1936

Gale, C., Ritchie, S. J., Starr, J. & Deary, I., 9 Jan 2020, In: Journal of Epidemiology & Community Health. 74, p. 108-113

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Sleep and brain morphological changes in the eighth decade of life

Aribisala, B. S., Riha, R. L., Valdes Hernandez, M., Maniega, S. M., Cox, S., Radakovic, R., Taylor, A., Pattie, A., Corley, J., Redmond, P., Bastin, M. E., Starr, J., Deary, I. & Wardlaw, J. M., Jan 2020, In: Sleep medicine. 65

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Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936

Ballerini, L., Booth, T., Hernández, M. D. C. V., Wiseman, S., Lovreglio, R., Maniega, S. M., Morris, Z., Pattie, A., Corley, J., Gow, A., Bastin, M. E., Deary, I. J. & Wardlaw, J., 2020, In: NeuroImage: Clinical. 25, 102120.

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2019

An epigenome-wide association study of sex-specific chronological ageing

McCartney, D. L., Zhang, F., Hillary, R., Zhang, Q., Stevenson, A. J., Walker, R. M., Bermingham, M. L., Boutin, T., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Hayward, C., Evans, K. L., Chandra, T., Deary, I. J., McIntosh, A. M., Yang, J., Visscher, P. M., & 2 othersMcRae, A. F. & Marioni, R. E., 31 Dec 2019, In: Genome Biology. 12, 1.

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Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income

Hill, W. D., Davies, N. M., Ritchie, S. J., Skene, N. G., Bryois, J., Bell, S., Di Angelantonio, E., Roberts, D. J., Xueyi, S., Davies, G., Liewald, D. C. M., Porteous, D. J., Hayward, C., Butterworth, A. S., Mcintosh, A. M., Gale, C. R. & Deary, I. J., 16 Dec 2019, In: Nature Communications. 10, 1, 5741.

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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., Bastin, M. E., Carrillo-roa, T., den Braber, A., Harris, M., Jansen, R., Liu, J., Luciano, M., Ori, A. P. S., Roiz-Santianez, R., Ruggeri, B., Sarkisyan, D., Shin, J., Sungeun, K., Tordesillas-Gutierrez, D., & 62 othersVan't Ent, D., Ames, D., Artiges, E., Bakalkin, G., Banaschewski, T., Bokde, A. L. W., Brodaty, H., Bromberg, U., Brouwer, R. M., Büchel, C., Quinlan, E. B., Cahn, W., de Zubicaray, G. I., Ehrlich, S., Ekström, T. J., Flor, H., Fröhner, J. H., Frouin, V., Garavan, H., Gowland, P. A., Heinz, A., Hoare, J., Ittermann, B., Jahanshad, N., Jiang, J., Kwok, J. B. J., Martin, N. G., Martinot, J-L., Mather, K. A., McMahon, K. L., Mcrae, A. F., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Sämann, P. G., Schofield, P. R., Smolka, M. N., Stein, D. J., Strike, L. T., Teeuw, J., Thalamuthu, A., Trollor, J. N., Walter, H., Wardlaw, J. M., Wen, W., Whelan, R., Apostolova, L. G., Binder, E. B., Boomsma, D., Calhoun, V. D., Crespo-Facorro, B., Deary, I. J., Hulshoff Pol, H. E., Ophoff, R. A., Pausova, Z., Sachdev, P. S., Saykin, A. J., Wright, M. J., Thompson, P. M., Schumann, G. & Desrivières, S., 6 Dec 2019, (E-pub ahead of print) In: Molecular Psychiatry. N/A, p. 1-12

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An epigenetic predictor of death captures multi-modal measures of brain health

Hillary, R., Stevenson, A. J., Cox, S. R., McCartney, D. L., Harris, S. E., Seeboth, A., Higham, J., Sproul, D., Taylor, A., Redmond, P., Corley, J., Pattie, A., del C. Valdés Hernández, M., Muñoz-Maniega, S., Bastin, M. E., Wardlaw, J. M., Horvath, S., Ritchie, C. W., Spires-Jones, T. L., McIntosh, A. M., & 3 othersEvans, K. L., Deary, I. J. & Marioni, R. E., 3 Dec 2019, In: Molecular Psychiatry. N/A, p. 1-11 11 p.

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A novel genetic locus influencing retinal venular tortuosity is also associated with risk of coronary artery disease

Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P., Relan, D., Harris, S., Brown, E., Vaidya, S. S., Dhillon, B., Zhou, K., Pearson, E. R., Hayward, C., Polasek, O., Deary, I., MacGillivray, T., Wilson, J., Trucco, E., & 2 othersPalmer, C. N. A. & Doney, A. S. F., Dec 2019, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552

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Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936

Hillary, R., McCartney, D. L., Harris, S., Stevenson, A., Seeboth, A., Zhang, Q., Liewald, D., Evans, K. L., Ritchie, C., Tucker-Drob, E. M., Wray, N. R., Mcrae, A. F., Visscher, P. M., Deary, I. & Marioni, R. E., Dec 2019, In: Nature Communications. 10, 3160.

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Retinal microvascular features and cognitive change in the Lothian Birth Cohort 1936

McGrory, S., Ballerini, L., Okely, J., Ritchie, S., Doubal, F., Doney, A. S. F., Starr, J., MacGillivray, T., Trucco, E., Wardlaw, J. & Deary, I., Dec 2019, In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 11, p. 500-509 10 p.

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Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., Van Der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V., & 269 othersLi, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., Den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C-Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., De Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., Van Eijk, K. R., Cavalleri, G. L., Van Der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., Van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B-C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J-J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., Van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., Van Tol, M-J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., Van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J-L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., Van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van ‘t Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., Van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., Destefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., Van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., Decarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., 30 Nov 2019, In: Nature Genetics. 51, 11, p. 1624–1636 13 p.

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Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

Stevenson, A., McCartney, D. L., Hillary, R., Redmond, P., Taylor, A., Zhang, Q., McRae, A., Spires-Jones, T., McIntosh, A., Deary, I. & Marioni, R., 28 Nov 2019, In: Translational Psychiatry. 9, 323.

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Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

Scottish Genomes Partnership, 25 Nov 2019, (E-pub ahead of print) In: PLoS Genetics. 15, 11, p. 1-29 30 p., e1008480.

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Cross-sectional associations between personality traits and device-based measures of step count and sedentary behaviour in older age: The Lothian Birth Cohort 1936

Seniors USP Team, Čukić, I., Gale, C., Chastin, S., Dall, P. M., Dontje, M., Skelton, D. A. & Deary, I., 10 Nov 2019, In: BMC Geriatrics. 19, 302

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Associations between Brief Resilience Scale scores and ageing-related domains in the Lothian Birth Cohort 1936

Taylor, A., Ritchie, S. J., Madden, C. & Deary, I., 4 Nov 2019, (E-pub ahead of print) In: Psychology and Aging. 35, 3, p. 329-344

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Longitudinal associations between loneliness and cognitive ability in the Lothian Birth Cohort 1936: 1376-1386

Okely, J. A. & Deary, I. J., Nov 2019, In: The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences. 74, 8, p. 1376-1386 gby086.

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Associations of autozygosity with a broad range of human phenotypes

Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-gomez, C., Karlsson, R., Bao, Y., Bartz, T. M., & 416 othersBaumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., Van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., De Haan, H. G., Harris, S. E., Hofer, E., Huerta-chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., Van Der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., Van Der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., De Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M., Chen, G., Chen, Y. I., Chen, Z., Chiu, Y., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., Van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., Van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K., Khor, C. C., De Kleijn, D. P. V., Koh, W., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I., Lee, W., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P., Moreno-macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., De Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., Van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., Van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-khayat, B., Sennblad, B., Van Setten, J., Sever, P. J., Sheu, W. H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., Van Den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., Van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., Van Der Harst, P., Heng, C., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., Van Der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., Mccarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O’connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 31 Oct 2019, In: Nature Communications. 10, 1

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The Disconnected Mind Phase 3

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