Research output per year
Research output per year
Project Details
Key findings
-Demonstrated that M cells are the main route of TSE agent uptake from the small intestine after oral exposure.
-Demonstrated for the first time that distinct mechanisms regulate the development of the GALT in the large and small intestines.
-Demonstrated for the first time that the large intestine is not a primary site of TSE agent neuroinvasion after oral exposure.
-Demonstrated for the first time that congruent parasite infection in the large intestine does not influence oral TSE pathogenesis or susceptibility.
-Demonstrated for the first time that a congruent parasite infection in the large intestine can exacerbate the onset of clinical TSE disease.
-Project still in progress and will be published as soon as ready.
-Demonstrated for the first time that distinct mechanisms regulate the development of the GALT in the large and small intestines.
-Demonstrated for the first time that the large intestine is not a primary site of TSE agent neuroinvasion after oral exposure.
-Demonstrated for the first time that congruent parasite infection in the large intestine does not influence oral TSE pathogenesis or susceptibility.
-Demonstrated for the first time that a congruent parasite infection in the large intestine can exacerbate the onset of clinical TSE disease.
-Project still in progress and will be published as soon as ready.
| Status | Finished |
|---|---|
| Effective start/end date | 5/05/09 → 31/10/12 |
Funding
- BBSRC: £437,902.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Accelerated onset of CNS prion disease in mice co-infected with a gastrointestinal helminth pathogen during the preclinical phase
Donaldson, D., Bradford, B., Else, K. J. & Mabbott, N., 12 Mar 2020, In: Scientific Reports. 10, 4554 (2020).Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The influence of commensal and pathogenic gut microbiota on prion disease pathogenesis
Donaldson, D. & Mabbott, N., 1 Aug 2016, (E-pub ahead of print) In: Journal of General Virology. 97, 8, p. 1725-1738Research output: Contribution to journal › Article › peer-review
Open AccessFile -
From scientific curiosity to public enemy number one in six short months
Mabbott, N., 14 Apr 2016, In: PLoS Pathogens. 12, 4, e1005371.Research output: Contribution to journal › Article › peer-review
Open AccessFile