The Networks Influencing Osteoclast Dysregulation Leading to Bone Invasion in Cancer

Project Details


Companion animal cancer cell lines provide a model for the disrupted microenvironment that stimulates osteoclasts to break down bone locally to facilitate cancer bone invasion and growth. This results in the local release of growth factors from the bone matrix beneficial for advanced tumour growth. This project aims to investigate the underlying signalling networks responsible for this vicious cycle.
Effective start/end date1/01/221/01/26


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