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The neuropathophysiology associated with Syngap mutations: further evidence for an mGluR5 signaling axis in ID/ASD
Kind, Peter
(Principal Investigator)
Daw, Michael
(Co-investigator)
Wyllie, David
(Co-investigator)
Deanery of Biomedical Sciences
Edinburgh Neuroscience
Overview
Fingerprint
Research output
(6)
Project Details
Status
Finished
Effective start/end date
1/03/13
→
31/08/16
Funding
MRC:
£839,856.00
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Fragile X Syndrome
Medicine & Life Sciences
100%
Dendritic Spines
Medicine & Life Sciences
84%
Fragile X Mental Retardation Protein
Medicine & Life Sciences
68%
Synapses
Medicine & Life Sciences
66%
Intellectual Disability
Medicine & Life Sciences
56%
Pyramidal Cells
Medicine & Life Sciences
47%
Farnesyltranstransferase
Medicine & Life Sciences
45%
rat Fmr1 protein
Medicine & Life Sciences
35%
Research output
Research output per year
2014
2015
2017
6
Article
Research output per year
Research output per year
Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses
Booker, S. A.
,
Campbell, G. R.
,
Mysiak, K. S.
,
Brophy, P. J.
,
Kind, P. C.
,
Mahad, D. J.
&
Wyllie, D. J. A.
,
15 Mar 2017
,
In:
Journal of Physiology.
595
,
6
,
p. 2147-2160
14 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Farnesyltranstransferase
100%
Pyramidal Cells
68%
Synapses
60%
Electron Transport Complex IV
46%
Electron Transport
43%
Altered Thalamocortical Development in the SAP102 Knockout Model of Intellectual Disability
Crocker-Buque, A.
,
Currie, S. P.
,
Luz, L. L.
,
Grant, S. G.
,
Duffy, K. R.
,
Kind, P. C.
&
Daw, M. I.
,
27 Jul 2016
, (E-pub ahead of print)
In:
Human Molecular Genetics.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
N-Methyl-D-Aspartate Receptors
100%
Intellectual Disability
94%
Somatosensory Cortex
57%
Guanylate Kinases
37%
Kinetics
36%
Convergence of hippocampal pathophysiology in
Syngap
+/-
and
Fmr1
-/y
mice
Barnes, S. A.
,
Wijetunge, L. S.
,
Jackson, A. D.
,
Katsanevaki, D.
,
Osterweil, E. K.
,
Komiyama, N. H.
,
Grant, S. G. N.
,
Bear, M. F.
,
Nägerl, U. V.
,
Kind, P. C.
&
Wyllie, D. J. A.
,
11 Nov 2015
,
In:
Journal of Neuroscience.
35
,
45
,
p. 15073-15081
9 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Autism Spectrum Disorder
100%
Intellectual Disability
90%
Haploinsufficiency
82%
Fragile X Syndrome
41%
Metabotropic Glutamate Receptors
40%