The role of non-histone proteins in chromosome structure and function during mitosis

Research output

Research output per year 2012 2014 2015 2016 2018 2019 2023

• 34 Article
• 1 Chapter (peer-reviewed)
• 1 Review article

Research output per year

Research output per year

Search results

• 2023

  Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli

  Liskovykh, M., Petrov, N. S., Noskov, V. N., Masumoto, H., Earnshaw, W. C., Schlessinger, D., Shabalina, S. A., Larionov, V. & Kouprina, N., 12 Apr 2023, In: Cellular and Molecular Life Sciences. 80, 5, 60 p., 121.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ribosomal DNA 100%
  • Association 100%
  • Nucleolus 100%
  • Acrocentric Chromosome 20%
  • Autosome 10%
• 2022

  Combination of CENP-B box positive and negative synthetic alpha satellite repeats improves de novo human artificial chromosome formation

  Okazaki, K., Nakano, M., Ohzeki, J. I., Otake, K., Kugou, K., Larionov, V., Earnshaw, W. C. & Masumoto, H., 19 Apr 2022, In: Cells. 11, 9, 17 p., 1378.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human Artificial Chromosome 100%
  • Chromatin 71%
  • DNA 57%
  • Heterochromatin 42%
  • Wild Type 28%
• 2021

  Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells

  Petrov, N. S., Lee, H-S., Liskovykh, M., Teulade-Fichou, M-P., Masumoto, H., Earnshaw, W. C., Pommier, Y., Larionov, V. & Kouprina, N., 20 Jul 2021, In: Oncotarget. 12, p. 1444-1456 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chromosomal Instability 100%
  • Malignant Neoplasm 100%
  • Platinum Derivative 100%
  • Telomere 100%
  • Cancer Cell 100%
• 2020

  CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly

  Otake, K., Ohzeki, J., Shono, N., Kugou, K., Okazaki, K., Nagase, T., Yamakawa, H., Kouprina, N., Larionov, V., Kimura, H., Earnshaw, W. C. & Masumoto, H., 11 Aug 2020, In: Journal of Cell Science. 133, jcs.243303.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Heterochromatin 100%
  • DNA 100%
  • Chromatin 100%
  • Kinetochore 40%
• 2019

  Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1

  Papini, D., Fant, X., Ogawa, H., Desban, N., Samejima, K., Feizbakhsh, O., Askin, B., Ly, T., Earnshaw, W. C. & Ruchaud, S., 6 Nov 2019, (E-pub ahead of print) In: Journal of Cell Science. jcs.234401.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mutation 100%
  • INCENP 100%
  • Phosphomimetics 100%
  • Cell Cycle 100%
  • Phosphorylation 50%

• Borealin–nucleosome interaction secures chromosome association of the chromosomal passenger complex

  Abad, M. A., Ruppert, J., Buzuk, L., Wear, M., Zou, J., Webb, K., Kelly, D., Voigt, P., Rappsilber, J., Earnshaw, W. & Arulanandam, A., 30 Sept 2019, In: Journal of Cell Biology. 218, 12, p. 3912–3925 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Association 100%
  • Chromosome 100%
  • INCENP 28%
  • Nucleosome 28%
  • Centromere 28%

• A novel assay to screen siRNA libraries identifies protein kinases as required for chromosome transmission

  Liskovykh, M., Goncharov, N. V., Petrov, N., Aksenova, V., Pegoraro, G., Ozbun, L. L., Reinhold, W. C., Varma, S., Dasso, M., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 12 Sept 2019, (E-pub ahead of print) In: Genome Research. 29, 9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein Kinase 100%
  • Small Interfering RNA 100%
  • Chromosome 100%
  • Chromosome Instability 100%
  • Nested Gene 83%

• De novo formation and epigenetic maintenance of centromere chromatin

  Ohzeki, J., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Jun 2019, In: Current opinion in cell biology. 58, p. 15-25 11 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Centromere 100%
  • Chromatin 100%
  • Kinetochore 50%
  • Sister Chromatid 50%

• In vitro BioID: Mapping the CENP-A microenvironment with high temporal and spatial resolution

  Remnant, L., Booth, D. G., Vargiu, G., Spanos, C., Kerr, A. R. W. & Earnshaw, W. C., 20 Mar 2019, (E-pub ahead of print) In: Molecular Biology of the Cell. 30, 11, p. 1314-1325 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Biotin 100%
  • Ligase 66%
  • Centromere 66%
  • Histone H3 33%
• 2018

  Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy

  Lee, H-S., Carmena, M., Liskovykh, M., Peat, E., Kim, J-H., Oshimura, M., Masumoto, H., Teulade-Fichou, M-P., Pommier, Y., Earnshaw, W. C., Larionov, V. & Kouprina, N., 30 Aug 2018, (E-pub ahead of print) In: Cancer Research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Telomere 100%
  • Telomerase 100%
  • Taxonomy 100%
  • Chromosome Loss 28%
  • Transgene 14%

• Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies

  Pesenti, E., Kouprina, N., Liskovykh, M., Aurich-Costa, J., Larionov, V., Masumoto, H., Earnshaw, W. C. & Molina, O., 20 Apr 2018, In: ACS Synthetic Biology. 7, 4, p. 1116-1130 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Human Chromosome 100%
  • Human Artificial Chromosome 100%
  • Chromatin 71%
  • Kinetochore 42%

• Isolation of mitotic chromosomes from vertebrate cells and characterisation of their proteome by mass spectrometry

  Samejima, I. & Earnshaw, W., 12 Apr 2018, (E-pub ahead of print) Methods in Cell Biology. Elsevier, Vol. 144. p. 329-348 20 p. (Methods in Cell Biology; vol. 144).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  • Proteome 100%
  • Mass Spectrometry 100%
  • Chromosome 100%
  • Protein 66%
  • DNA 50%

• A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

  Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M., & 26 othersSvensson, R., Gustavsson, A-L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In: Nature Communications. 9, 1, 14 p., 1107 (2018).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Killing 100%
  • Dihydroorotate Dehydrogenase 100%
  • P53 100%
  • Degradation 100%
  • Synthesis 100%
• 2017

  Using human artificial chromosomes to study centromere assembly and function

  Molina, O., Kouprina, N., Masumoto, H., Larionov, V. & Earnshaw, W., 1 Oct 2017, In: Chromosoma. p. 559-575 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Centromere 100%
  • Human Artificial Chromosome 100%
  • Kinetochore 33%
  • Epigenetics 16%
  • Transcription 16%

• Molecular Basis for Cdk1 Regulated Timing of Mis18 Complex Assembly and CENP-A Deposition

  Spiller, F., Medina-Pritchard, B., Alba Abad, M., Wear, M., Molina, O., Earnshaw, W. & Arulanandam, A., 4 Apr 2017, In: EMBO Reports. e201643564.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Centromere 100%
  • Cell Cycle 66%
  • Regulatory Mechanism 66%
  • Amino Acids 33%
  • Nucleosome 33%
• 2016

  PREditOR: A synthetic biology approach to removing heterochromatin from cells

  Molina, O., Carmena, M., Maudlin, I. E. & Earnshaw, W. C., 6 Dec 2016, In: Chromosome Research. 24, 4, p. 495-509

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heterochromatin 100%
  • Reading 100%
  • Protein 100%
  • Enzyme Inhibitor 20%
  • Gene Knockdown 20%

• Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance: H3K4me2 is necessary for kinetochore assembly and function

  Molina, O., Vargiu, G., Alba Abad, M., Zhiteneva, A., Arulanandam, J., Masumoto, H., Kouprina, N., Larionov, V. & Earnshaw, W., 14 Nov 2016, In: Nature Communications. 51 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Histone Modification 100%
  • Transcription 100%
  • Kinetochore 100%
  • Centromere 62%

• KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation

  Ohzeki, J-I., Shono, N., Otake, K., Martins, N. M. C., Kugou, K., Kimura, H., Nagase, T., Larionov, V., Earnshaw, W. C. & Masumoto, H., 6 Jun 2016, In: Developmental Cell. 37, 5, p. 413-27 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chromatin Remodeling 100%
  • Centromere 100%
  • Heterochromatin 60%
  • Chromatin 60%
  • Histone H3 40%

• Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells

  Kim, J. H., Lee, H. S., Lee, N. C. O., Goncharov, N. V., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Kouprina, N. & Larionov, V., 22 Mar 2016, In: Oncotarget. 7, 12, p. 14841-14856 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Development 100%
  • Human Artificial Chromosome 100%
  • Cancer Cell 100%
  • Chromosome Instability 100%
  • Transgene 22%

• Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3

  Martins, N. M. C., Bergmann, J. H., Shono, N., Kimura, H., Larionov, V., Masumoto, H. & Earnshaw, W. C., 1 Jan 2016, In: Molecular Biology of the Cell. 27, 1, p. 177-96 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Centromere 100%
  • Transcription 25%
  • Heterochromatin 25%
  • Human Artificial Chromosome 25%
• 2015

  Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette

  Kononenko, A. V., Lee, N. C. O., Liskovykh, M., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 20 May 2015, In: Nucleic Acids Research. 43, 9, e57.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Self Concept 100%
  • Gene Targeting 100%
  • Nested Gene 100%
  • Human Artificial Chromosome 100%
  • Expression Cassette 100%

• CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly

  Ohta, S., Wood, L., Toramoto, I., Yagyu, K. I., Fukagawa, T. & Earnshaw, W. C., 15 Apr 2015, In: Molecular Biology of the Cell. 26, 7, p. 1225-1237 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Centromere 100%
  • Proteins 100%
  • Centrosome 60%
  • Microtubule 30%

• Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing

  Castonguay, E., White, S. A., Kagansky, A., St-Cyr, D. J., Castillo, A. G., Brugger, C., White, R., Bonilla, C., Spitzer, M., Earnshaw, W. C., Schalch, T., Ekwall, K., Tyers, M. & Allshire, R. C., 1 Jan 2015, In: Molecular and Cellular Biology. 35, 4, p. 662-674 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heterochromatin 100%
  • Gene Silencing 100%
  • Small Molecule 100%
  • Histone 57%
  • Transgene 28%

• CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly

  Shono, N., Ohzeki, J. I., Otake, K., Martins, N. M. C., Nagase, T., Kimura, H., Larionov, V., Earnshaw, W. C. & Masumoto, H., 2015, In: Journal of Cell Science. 128, 24, p. 4572-4587 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kinetochore 100%
  • Centromere 100%
  • Chromatin 60%
  • DNA 40%
  • Epigenetics 20%
• 2014

  A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function

  Kononenko, A. V., Bansal, R., Lee, N. C. O., Grimes, B. R., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 1 Dec 2014, In: Nucleic Acids Research. 42, 21, e164.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • BRCA1 100%
  • Tumor Suppressor Protein 100%
  • Human Artificial Chromosome 100%
  • Kinetochore 30%
  • Transcription 23%

• The Centromere: Chromatin Foundation for the Kinetochore Machinery

  Fukagawa, T. & Earnshaw, W. C., 8 Sept 2014, In: Developmental Cell. 30, 5, p. 496-508 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chromatin 100%
  • Kinetochore 100%
  • Centromere 100%
  • DNA Sequence 33%
  • Histone H3 16%

• Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly

  Hori, T., Shang, W-H., Toyoda, A., Misu, S., Monma, N., Ikeo, K., Molina, O., Vargiu, G., Fujiyama, A., Kimura, H., Earnshaw, W. C. & Fukagawa, T., 23 Jun 2014, In: Developmental Cell. 29, 6, p. 740-9 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Histone H4 100%
  • Nucleosome 100%
  • Kinetochore 100%
  • Centromere 100%
  • Chicken 22%

• Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery

  Booth, D. G., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C. P., Tollervey, D., Earnshaw, W. C. & Vagnarelli, P., 27 May 2014, In: eLIFE. 3, 22 p., e01641.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Chromosome 100%
  • Mitosis 50%
  • Association 50%
  • Chromosome Condensation 25%

• DNA content of a functioning chicken kinetochore

  Ribeiro, S. A., Vagnarelli, P. & Earnshaw, W. C., 15 Mar 2014, In: Chromosome Research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chicken 100%
  • Kinetochore 100%
  • DNA Content 100%
  • DNA 37%
  • Chromatin 25%

• Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster

  Carmena, M., Lombardia, M. O., Ogawa, H. & Earnshaw, W. C., 1 Jan 2014, In: Open Biology. 4, 11, 140162.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Meiosis 100%
  • Mitosis 100%
  • Drosophila Melanogaster 100%
  • Polo Kinase 100%
  • Kinase 50%

• Targeting the INCENP in-box-Aurora B interaction to inhibit CPC activity in vivo

  Gohard, F. H., St-Cyr, D. J., Tyers, M. & Earnshaw, W. C., 1 Jan 2014, In: Open Biology. 4, 11, 140163.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chromosome 100%
  • Centromere 100%
  • Protein 100%
  • Cells 42%
  • Peptide 28%
• 2013

  Protecting a transgene expression from the HAC-based vector by different chromatin insulators

  Lee, N. C., Kononenko, A. V., Lee, H-S., Larionov, V., Kouprina, N., Tolkunova, E. N., Liskovykh, M. A., Tomilin, A. N., Masumoto, H. & Earnshaw, W. C., 16 May 2013, In: Cellular and Molecular Life Sciences. 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transgene 100%
  • Chromatin 100%
  • Human Artificial Chromosome 100%
  • Nested Gene 57%
  • Transgenics 28%

• Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres

  Shang, W-H., Hori, T., Fukagawa, T., Toyoda, A., Fujiyama, A., Misu, S., Monma, N., Ikeo, K., Hiratani, I., Maeshima, K., Martins, N. M. C., Earnshaw, W. C. & Kimura, H., 25 Mar 2013, In: Developmental Cell. 24, 6, p. 635-648 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Neocentromere 100%
  • Centromere 60%
  • Histone H3 10%
  • Chicken 10%
  • Histone Modification 10%

• Nap1 regulates proper CENP-B binding to nucleosomes

  Tachiwana, H., Miya, Y., Shono, N., Ohzeki, J-I., Osakabe, A., Otake, K., Larionov, V., Earnshaw, W. C., Kimura, H., Masumoto, H. & Kurumizaka, H., 2013, In: Nucleic Acids Research. 41, 5, p. 2869-2880 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nucleosome 100%
  • Chromosome 33%
  • Satellite DNA 33%
  • Histone 33%
  • Histone H3 16%
• 2012

  The chromosomal passenger complex (CPC): From easy rider to the godfather of mitosis

  Carmena, M., Earnshaw, W. C., Wheelock, M. & Funabiki, H., Dec 2012, In: Nature reviews Molecular cell biology. 13, 12, p. 789-803 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitosis 100%
  • Chromosome 66%
  • Spindle Checkpoint 33%
  • Phosphotransferase 33%
  • Regulatory Mechanism 33%

• HACking the centromere chromatin code: Insights from human artificial chromosomes

  Bergmann, J. H., Larionov, V., Masumoto, H., Martins, N. M. C. & Earnshaw, W. C., Jul 2012, In: Chromosome Research . 20, 5, p. 505-519 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Artificial Chromosome 100%
  • Introspection 100%
  • Centromere 100%
  • Chromatin 100%
  • Kinetochore 50%