Research output per year
Research output per year
- 34 results
Search results
-
2023
Actively transcribed rDNA and distal junction (DJ) sequence are involved in association of NORs with nucleoli
Liskovykh, M., Petrov, N. S., Noskov, V. N., Masumoto, H., Earnshaw, W. C., Schlessinger, D., Shabalina, S. A., Larionov, V. & Kouprina, N., 12 Apr 2023, In: Cellular and Molecular Life Sciences. 80, 5, 60 p., 121.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2022
Combination of CENP-B box positive and negative synthetic alpha satellite repeats improves de novo human artificial chromosome formation
Okazaki, K., Nakano, M., Ohzeki, J. I., Otake, K., Kugou, K., Larionov, V., Earnshaw, W. C. & Masumoto, H., 19 Apr 2022, In: Cells. 11, 9, 17 p., 1378.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2021
Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells
Petrov, N. S., Lee, H-S., Liskovykh, M., Teulade-Fichou, M-P., Masumoto, H., Earnshaw, W. C., Pommier, Y., Larionov, V. & Kouprina, N., 20 Jul 2021, In: Oncotarget. 12, p. 1444-1456 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2020
CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly
Otake, K., Ohzeki, J., Shono, N., Kugou, K., Okazaki, K., Nagase, T., Yamakawa, H., Kouprina, N., Larionov, V., Kimura, H., Earnshaw, W. C. & Masumoto, H., 11 Aug 2020, In: Journal of Cell Science. 133, jcs.243303.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2019
Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1
Papini, D., Fant, X., Ogawa, H., Desban, N., Samejima, K., Feizbakhsh, O., Askin, B., Ly, T., Earnshaw, W. C. & Ruchaud, S., 6 Nov 2019, (E-pub ahead of print) In: Journal of Cell Science. jcs.234401.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Borealin–nucleosome interaction secures chromosome association of the chromosomal passenger complex
Abad, M. A., Ruppert, J., Buzuk, L., Wear, M., Zou, J., Webb, K., Kelly, D., Voigt, P., Rappsilber, J., Earnshaw, W. & Arulanandam, A., 30 Sept 2019, In: Journal of Cell Biology. 218, 12, p. 3912–3925 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A novel assay to screen siRNA libraries identifies protein kinases as required for chromosome transmission
Liskovykh, M., Goncharov, N. V., Petrov, N., Aksenova, V., Pegoraro, G., Ozbun, L. L., Reinhold, W. C., Varma, S., Dasso, M., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 12 Sept 2019, (E-pub ahead of print) In: Genome Research. 29, 9Research output: Contribution to journal › Article › peer-review
Open AccessFile -
In vitro BioID: Mapping the CENP-A microenvironment with high temporal and spatial resolution
Remnant, L., Booth, D. G., Vargiu, G., Spanos, C., Kerr, A. R. W. & Earnshaw, W. C., 20 Mar 2019, (E-pub ahead of print) In: Molecular Biology of the Cell. 30, 11, p. 1314-1325 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2018
Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy
Lee, H-S., Carmena, M., Liskovykh, M., Peat, E., Kim, J-H., Oshimura, M., Masumoto, H., Teulade-Fichou, M-P., Pommier, Y., Earnshaw, W. C., Larionov, V. & Kouprina, N., 30 Aug 2018, (E-pub ahead of print) In: Cancer Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies
Pesenti, E., Kouprina, N., Liskovykh, M., Aurich-Costa, J., Larionov, V., Masumoto, H., Earnshaw, W. C. & Molina, O., 20 Apr 2018, In: ACS Synthetic Biology. 7, 4, p. 1116-1130 15 p.Research output: Contribution to journal › Article › peer-review
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A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M., & 26 others, 16 Mar 2018, In: Nature Communications. 9, 1, 14 p., 1107 (2018).Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
Using human artificial chromosomes to study centromere assembly and function
Molina, O., Kouprina, N., Masumoto, H., Larionov, V. & Earnshaw, W., 1 Oct 2017, In: Chromosoma. p. 559-575 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Molecular Basis for Cdk1 Regulated Timing of Mis18 Complex Assembly and CENP-A Deposition
Spiller, F., Medina-Pritchard, B., Alba Abad, M., Wear, M., Molina, O., Earnshaw, W. & Arulanandam, A., 4 Apr 2017, In: EMBO Reports. e201643564.Research output: Contribution to journal › Article › peer-review
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2016
PREditOR: A synthetic biology approach to removing heterochromatin from cells
Molina, O., Carmena, M., Maudlin, I. E. & Earnshaw, W. C., 6 Dec 2016, In: Chromosome Research. 24, 4, p. 495-509Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance: H3K4me2 is necessary for kinetochore assembly and function
Molina, O., Vargiu, G., Alba Abad, M., Zhiteneva, A., Arulanandam, J., Masumoto, H., Kouprina, N., Larionov, V. & Earnshaw, W., 14 Nov 2016, In: Nature Communications. 51 p.Research output: Contribution to journal › Article › peer-review
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KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation
Ohzeki, J-I., Shono, N., Otake, K., Martins, N. M. C., Kugou, K., Kimura, H., Nagase, T., Larionov, V., Earnshaw, W. C. & Masumoto, H., 6 Jun 2016, In: Developmental Cell. 37, 5, p. 413-27 15 p.Research output: Contribution to journal › Article › peer-review
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Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells
Kim, J. H., Lee, H. S., Lee, N. C. O., Goncharov, N. V., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Kouprina, N. & Larionov, V., 22 Mar 2016, In: Oncotarget. 7, 12, p. 14841-14856 16 p.Research output: Contribution to journal › Article › peer-review
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Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3
Martins, N. M. C., Bergmann, J. H., Shono, N., Kimura, H., Larionov, V., Masumoto, H. & Earnshaw, W. C., 1 Jan 2016, In: Molecular Biology of the Cell. 27, 1, p. 177-96 20 p.Research output: Contribution to journal › Article › peer-review
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2015
Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette
Kononenko, A. V., Lee, N. C. O., Liskovykh, M., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 20 May 2015, In: Nucleic Acids Research. 43, 9, e57.Research output: Contribution to journal › Article › peer-review
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CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly
Ohta, S., Wood, L., Toramoto, I., Yagyu, K. I., Fukagawa, T. & Earnshaw, W. C., 15 Apr 2015, In: Molecular Biology of the Cell. 26, 7, p. 1225-1237 13 p.Research output: Contribution to journal › Article › peer-review
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Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing
Castonguay, E., White, S. A., Kagansky, A., St-Cyr, D. J., Castillo, A. G., Brugger, C., White, R., Bonilla, C., Spitzer, M., Earnshaw, W. C., Schalch, T., Ekwall, K., Tyers, M. & Allshire, R. C., 1 Jan 2015, In: Molecular and Cellular Biology. 35, 4, p. 662-674 13 p.Research output: Contribution to journal › Article › peer-review
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CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly
Shono, N., Ohzeki, J. I., Otake, K., Martins, N. M. C., Nagase, T., Kimura, H., Larionov, V., Earnshaw, W. C. & Masumoto, H., 2015, In: Journal of Cell Science. 128, 24, p. 4572-4587 16 p.Research output: Contribution to journal › Article › peer-review
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2014
A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function
Kononenko, A. V., Bansal, R., Lee, N. C. O., Grimes, B. R., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 1 Dec 2014, In: Nucleic Acids Research. 42, 21, e164.Research output: Contribution to journal › Article › peer-review
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The Centromere: Chromatin Foundation for the Kinetochore Machinery
Fukagawa, T. & Earnshaw, W. C., 8 Sept 2014, In: Developmental Cell. 30, 5, p. 496-508 13 p.Research output: Contribution to journal › Article › peer-review
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Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly
Hori, T., Shang, W-H., Toyoda, A., Misu, S., Monma, N., Ikeo, K., Molina, O., Vargiu, G., Fujiyama, A., Kimura, H., Earnshaw, W. C. & Fukagawa, T., 23 Jun 2014, In: Developmental Cell. 29, 6, p. 740-9 10 p.Research output: Contribution to journal › Article › peer-review
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Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery
Booth, D. G., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C. P., Tollervey, D., Earnshaw, W. C. & Vagnarelli, P., 27 May 2014, In: eLIFE. 3, 22 p., e01641.Research output: Contribution to journal › Article › peer-review
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DNA content of a functioning chicken kinetochore
Ribeiro, S. A., Vagnarelli, P. & Earnshaw, W. C., 15 Mar 2014, In: Chromosome Research.Research output: Contribution to journal › Article › peer-review
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Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster
Carmena, M., Lombardia, M. O., Ogawa, H. & Earnshaw, W. C., 1 Jan 2014, In: Open Biology. 4, 11, 140162.Research output: Contribution to journal › Article › peer-review
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Targeting the INCENP in-box-Aurora B interaction to inhibit CPC activity in vivo
Gohard, F. H., St-Cyr, D. J., Tyers, M. & Earnshaw, W. C., 1 Jan 2014, In: Open Biology. 4, 11, 140163.Research output: Contribution to journal › Article › peer-review
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2013
Protecting a transgene expression from the HAC-based vector by different chromatin insulators
Lee, N. C., Kononenko, A. V., Lee, H-S., Larionov, V., Kouprina, N., Tolkunova, E. N., Liskovykh, M. A., Tomilin, A. N., Masumoto, H. & Earnshaw, W. C., 16 May 2013, In: Cellular and Molecular Life Sciences. 15 p.Research output: Contribution to journal › Article › peer-review
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Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres
Shang, W-H., Hori, T., Fukagawa, T., Toyoda, A., Fujiyama, A., Misu, S., Monma, N., Ikeo, K., Hiratani, I., Maeshima, K., Martins, N. M. C., Earnshaw, W. C. & Kimura, H., 25 Mar 2013, In: Developmental Cell. 24, 6, p. 635-648 14 p.Research output: Contribution to journal › Article › peer-review
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Nap1 regulates proper CENP-B binding to nucleosomes
Tachiwana, H., Miya, Y., Shono, N., Ohzeki, J-I., Osakabe, A., Otake, K., Larionov, V., Earnshaw, W. C., Kimura, H., Masumoto, H. & Kurumizaka, H., 2013, In: Nucleic Acids Research. 41, 5, p. 2869-2880 12 p.Research output: Contribution to journal › Article › peer-review
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2012
The chromosomal passenger complex (CPC): From easy rider to the godfather of mitosis
Carmena, M., Earnshaw, W. C., Wheelock, M. & Funabiki, H., Dec 2012, In: Nature reviews Molecular cell biology. 13, 12, p. 789-803 15 p.Research output: Contribution to journal › Article › peer-review
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HACking the centromere chromatin code: Insights from human artificial chromosomes
Bergmann, J. H., Larionov, V., Masumoto, H., Martins, N. M. C. & Earnshaw, W. C., Jul 2012, In: Chromosome Research . 20, 5, p. 505-519 15 p.Research output: Contribution to journal › Article › peer-review