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The role of the microenvironment in the initiation and maintenance of infant leukaemia
Ottersbach, Katrin
(Principal Investigator)
School of Regeneration and Repair
Overview
Fingerprint
Research output
(2)
Project Details
Status
Active
Effective start/end date
1/01/24
→
31/12/28
Funding
Cancer Research UK:
£1,697,348.63
View all
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
AFF1
Biochemistry, Genetics and Molecular Biology
100%
MicroRNA
Biochemistry, Genetics and Molecular Biology
100%
B Cell
Biochemistry, Genetics and Molecular Biology
100%
KMT2A
Biochemistry, Genetics and Molecular Biology
100%
Precursor
Biochemistry, Genetics and Molecular Biology
100%
Leukemia Cell
Immunology and Microbiology
100%
Central Nervous System
Immunology and Microbiology
100%
Lineages
Immunology and Microbiology
100%
Research output
Research output per year
2025
2025
2026
2026
2
Article
Research output per year
Research output per year
A microRNA expression signature in infant t(4;11) KMT2A::AFF1+ BCP-ALL uncovers novel therapeutic targets
Malouf, C.,
Duguid, A.
, Vrenken, K. S.,
Leah, T.
,
Medhi, R.
,
Camiolo, G.
, Nitsche, L.,
Jakobczyk, H.
, Kotecha, R. S.,
Anderson, R. A.
, Barrett, N., Smith, O. P., Stam, R. W. &
Ottersbach, K.
,
23 Apr 2026
,
In:
HemaSphere.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
MicroRNA
100%
Precursor
100%
B Cell
100%
KMT2A
100%
AFF1
100%
Mixed-lineage leukaemia cells undergo unique adaptations in the CNS niche
Duguid, A., Malouf, C., Nitsche, L., Halsey, C. &
Ottersbach, K.
,
8 Dec 2025
, (E-pub ahead of print)
In:
Experimental Hematology.
154
, 105347.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Lineages
100%
Central Nervous System
100%
Leukemia Cell
100%
Immunosuppressive Drug
8%
Engraftment
8%