Transfer from Sheffield: Regulation or neutrophilic inflammation by the HIF/PHD pathway

2025

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

Sadiku, P., Brenes, A. J., Mayer, R. L., Reyes, L., Coelho, P., Van Stralen, G., Zhang, A., Sanchez-Garcia, M. A., Watts, E. R., Liaquat, I., Howden, A. J. M., Adekoya, I., Boldbaatar, A., MacRaild, A., Risbridger, S., Morrison, G. M., MacPherson, H., Bruce, C., Johnston, S. & Grecian, R. & 5 others, Murphy, F. A., Pollard, S. M., Brennan, P., Mechtler, K. & Walmsley, S. R., 15 Dec 2025, In: Nature Communications. 17, 621 .

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Acute hypoxia drives long-term dysfunctional neutrophil immunity

Sanchez Garcia, M. A. & Walmsley, S. R., 28 Oct 2025, In: Nature Immunology. 26, 11, p. 1861-1862 2 p.

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Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

Sanchez-Garcia, M. A., Sadiku, P., Ortmann, B. M., Wit, N., Negishi, Y., Coelho, P., Zhang, A., Pednekar, C., Howden, A. J. M., Griffith, D. M., Seear, R., Kindrick, J. D., Mengede, J., Cooper, G., Morrison, T., Watts, E. R., Shimeld, B. T., Reyes, L., Mirchandani, A. S. & Arienti, S. & 30 others, Xu, X., Thomson, A., Brenes, A. J., Turton, H. A., Dowey, R., Hull, R. C., Davidson-Smith, H., McLaren, A., Deans, A., Choudhury, G., Doverman, K., Hope, D., Vick, O., Woodhead, A., Petrie, I., Green, S., Rzechorzek, N. M., Turtle, L., Openshaw, P. J. M., Semple, M. G., PHOSP‐COVID Study Collaborative Group, Sproul, D., Baillie, J. K., Thompson, A. A. R., Mole, D. R., von Kriegsheim, A., Whyte, M. K. B., Mhalanga, M. M., Nathan, J. A. & Walmsley, S. R., 28 Oct 2025, In: Nature Immunology. 26, 11, p. 1903-1915 13 p.

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2023

NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

Ryan, E., Sadiku, P., Coelho, P., Watts, E. R., Zhang, A., Howden, A. J. M., Sanchez Garcia, M. A., Bewley, M. A., Cole, J., McHugh, B., Vermaelen, W., Ghesquiere, B., Carmeliet, P., Rodriguez Blanco, G., von Kriegsheim, A., Sanchez, Y., Rumsey, W., Callahan, J. F., Cooper, G. & Parkinson, N. & 8 others, Baillie, J. K., Cantrell, D., McCafferty, J., Choudhury, G., Singh, D., Dockrell, D. H., Whyte, M. K. B. & Walmsley, S. R., 1 Feb 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.

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2022

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Sanchez Garcia, M. A., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Morrison, T., Ly, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R., Reyes, L., Cooper, G., Clark, S., Lewis, D. & Kelly, V. & 22 others, Spanos, C., Musgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N., Rostron, A. J., Baillie, J. K., Clohisey, S., Pridans, C., Campana, L., Starkey Lewis, P., Simpson, A. J., Dockrell, D. H., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. B. & Walmsley, S. R., 27 May 2022, In: Nature Immunology.

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2021

Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism

Watts, E. R., Howden, A. J. M., Morrison, T., Sadiku, P., Hukelmann, J. L., Von Kriegsheim, A., Ghesquière, B., Murphy, F., Mirchandani, A. S., Humphries, D. C., Grecian, R., Ryan, E. M., Coelho, P., Rodriguez-blanco, G., Plant, T. M., Dickinson, R. S., Finch, A. J., Vermaelen, W., Cantrell, D. A. & Whyte, M. K. B. & 1 others, Walmsley, S. R., 6 Apr 2021, (E-pub ahead of print) In: Journal of Clinical Investigation.

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Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Sadiku, P., Willson, J. A., Ryan, E. M., Sammut, D., Coelho, P., Watts, E. R., Grecian, R., Young, J. M., Bewley, M., Arienti, S., Mirchandani, A. S., Sanchez Garcia, M. A., Morrison, T., Zhang, A., Reyes, L., Griessler, T., Jheeta, P., Paterson, G. G., Graham, C. J. & Thompson, J. P. & 16 others, Baillie, K., Thompson, A. A. R., Morgan, J.-M., Acosta-Sanchez, A., Dardé, V. M., Duran, J., Guinovart, J. J., Rodriguez-Blanco, G., Von Kriegsheim, A., Meehan, R. R., Mazzone, M., Dockrell, D. H., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 2 Feb 2021, In: Cell Metabolism. 33, 2, p. 411-423.e4

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2020

Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

Plant, T., Eamsamarng, S., Sanchez-Garcia, M. A., Reyes, L., Renshaw, S. A., Coelho, P., Mirchandani, A. S., Morgan, J.-M., Ellett, F. E., Morrison, T., Humphries, D., Watts, E. R., Murphy, F., Raffo-Iraolagoitia, X. L., Zhang, A., Cash, J. L., Loynes, C., Elks, P. M., Van Eeden, F. & Carlin, L. M. & 3 others, Furley, A. J. W., Whyte, M. K. B. & Walmsley, S. R., 1 Jun 2020, In: Journal of Clinical Investigation. 130, 6, p. 3221-3237

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2019

IL4Rα signaling abrogates hypoxic neutrophil survival and limits acute lung injury responses in vivo

Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'Kane, C., McAuley, D. & Jenkins, S. J. & 2 others, Whyte, M. K. B. & Walmsley, S. R., 15 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 2, p. 235–246 12 p.

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2018

Hypoxia and reprogramming of host pathogen interactions

Ryan, E. M., Whyte, M. K. & Walmsley, S. R., 27 Nov 2018, (E-pub ahead of print) In: Current opinion in physiology. 7, p. 15-20

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2017

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo

Dickinson, R. S., Murphy, F., Doherty, C., Williams, S., Mirchandani, A., Willson, J. A., Scotti, J. S., Preston, G., Schofield, C. J., Whyte, M. K. B. & Walmsley, S. R., 26 Oct 2017, In: Wellcome Open Research . 2, p. 104

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Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Sadiku, P., Willson, J. A., Dickinson, R., Murphy, F., Harris, A., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E., Watts, E. R., Thompson, A. A. R., Marriott, H. M., Dockrell, D. H., Taylor, C. T., Schneider, M., Maxwell, P. H., Chilvers, E. R., Mazzone, M., Moral, V. & Pugh, C. W. & 6 others, Ratcliffe, P. J., Schofield, C. J., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 1 Sept 2017, In: Journal of Clinical Investigation. 127, 9, p. 3407-3420 14 p.

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Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

Thompson, A. A. R., Dickinson, R. S., Murphy, F., Thomson, J. P., Marriott, H. M., Tavares, A., Willson, J., Williams, L., Lewis, A., Mirchandani, A., Dos Santos Coelho, P., Doherty, C., Ryan, E., Watts, E., Morton, N. M., Forbes, S., Stimson, R. H., Hameed, A. G., Arnold, N. & Preston, J. A. & 15 others, Lawrie, A., Finisguerra, V., Mazzone, M., Sadiku, P., Goveia, J., Taverna, F., Carmeliet, P., Foster, S. J., Chilvers, E. R., Cowburn, A. S., Dockrell, D. H., Johnson, R. S., Meehan, R. R., Whyte, M. K. B. & Walmsley, S. R., 24 Feb 2017, In: Science Immunology. 2, 8, eaal2861.

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2015

Exploring the HIFs, Buts and Maybes of Hypoxia Signalling in Disease: Lessons From Zebrafish Models

Elks, P. M., Renshaw, S. A., Meijer, A. H., Walmsley, S. & Van Eeden, F. J., 1 Nov 2015, In: Disease Models and Mechanisms. 8, 11, p. 1349-1360

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Transfer from Sheffield: Regulation or neutrophilic inflammation by the HIF/PHD pathway

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