Transforming endometriosis care in Europe: an integrated approach to enhance understanding, diagnosis, tailored management and patient empowerment

With involvement of patient organisations and patients with diverse real-life experiences across Europe, we will explore how patients perceive self-management in the light of existing stigma and dismissal in clinical interactions. We will conduct a randomised controlled trial to evaluate the effectiveness of dietary intervention and cognitive behavioural therapy on endometriosis-related pain and subfertility, aiming at developing new treatment options and practical tools. Analysing steroid metabolomics and microRNA profiling will provide a powerful diagnostic approach able to predict the effectiveness of interventions and the likelihood of recurrence, while investigating the link between microbiota health, local epigenetic alterations, immune response and endometriosis development will yield a better understanding of disease mechanisms. Utilising eHealth-based technologies and AI/machine learning, we will also develop models that can predict responses to lifestyle behaviours.