Using synaptogenic proteins to repair the damaged synaptome

Synapses are the vital connections that link neurons into circuits and are damaged or lost in a wide range of disorders including autism spectrum disorder, intellectual disability and neurodegeneration. This one-year collaboration between Prof. Seth Grant (Edinburgh) and Prof. Tim Kennedy (McGill) will develop approaches to repairing damaged synapses by harnessing new synaptomic technology to the biology of synaptogenesis. By bringing this state-of-the-art technology to the forefront of research in the field of synaptogenesis and synapse regeneration the project aims to reveal new insights into the mechanisms generating synapse diversity and to identify new therapeutic pathways toward targeted repair of specific brain synapse subtypes.