α1 and α2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics

C.F. Suárez, P.P. Cárdenas, E.J. Llanos-Ballestas, P. Martínez, M. Obregón, M.E. Patarroyo, M.A. Patarroyo

Research output: Contribution to journalArticlepeer-review

Abstract

Functional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps and A. vociferans). We found 24 sequences, which divided into two different groups (Ao-g1 and Ao-g2). A further sequence was identified as a processed pseudogene (Aona-PS2). Both sequence evolution and variability analyses showed that Ao-g1 and Ao-g2 display similar characteristics to Catarrhini's classical loci, such as positive selection pressure at the peptide binding region (PBR) high variability and a trans-specific evolution pattern.
Original languageEnglish
Pages (from-to)362-373
Number of pages12
JournalTissue antigens
Volume61
Issue number5
DOIs
Publication statusPublished - 1 May 2003

Keywords

  • animal models
  • Aotus
  • evolution
  • MHC class I
  • PBR
  • Platyrrhini

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