β-Defensins: multifunctional modulators of infection, inflammation and more?

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Defensins comprise one of the largest groups of host defence peptides, present throughout evolution, in fungi and flowering plants as well as in invertebrates and vertebrates. These cysteine-rich, cationic peptides have a common ability to kill a broad range of microorganisms including bacteria, yeast and viruses. As such, they are a strong component of the arsenal that is an organism's innate immunity. It is becoming increasingly clear, however, that antimicrobial action is only one of the numerous roles of these multifunctional peptides. In recent years, the functions of defensins in immunomodulation have been widely investigated, and their involvement in other processes (such as fertility) is becoming evident. This review addresses recent advances in the immunomodulatory activity of β-defensins as well as the involvement of β-defensins in fertility, development, wound healing and cancer.
Original languageEnglish
Pages (from-to)337-48
Number of pages12
JournalJournal of Innate Immunity
Volume4
Issue number4
DOIs
Publication statusPublished - 2012

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Anti-Infective Agents
  • Female
  • Fertility
  • Host-Pathogen Interactions
  • Humans
  • Immunologic Factors
  • Inflammation
  • Male
  • Neoplasms
  • Rats
  • Wound Healing
  • beta-Defensins

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