11Beta-hydroxysteroid dehydrogenases in human endometrium

Sarah E McDonald, Teresa A Henderson, Celso E Gomez-Sanchez, Hilary O D Critchley, J Ian Mason

Research output: Contribution to journalArticlepeer-review

Abstract

Key reproductive events, such as menstruation and implantation, are considered to be inflammatory processes and glucocorticoids act as anti-inflammatory agents. The balance of expression of types 1 and 2 11beta-hydroxysteroid dehydrogenases (11betaHSD) controls the availability of cortisol to bind to the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). Expression profiles of glucocorticoid-metabolising enzymes and their cognate receptors have been characterized in the reproductive tract. We propose that factors that peripherally promote glucocorticoid action are part of an anti-inflammatory response to tissue remodelling in human endometrium. Protein and mRNA expression in endometrium were investigated using immunohistochemistry and quantitative real-time PCR. There was up-regulated expression of 11betaHSD-1 at menstruation and in first trimester decidua. 11BetaHSD-2 and GR were expressed across the cycle. The MR expression pattern across the cycle and in decidua implies progesterone may also play a regulatory role. The precise roles and interactions of these proteins require further investigation.
Original languageEnglish
Pages (from-to)72-8
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume248
Issue number1-2
DOIs
Publication statusPublished - 2006

Fingerprint

Dive into the research topics of '11Beta-hydroxysteroid dehydrogenases in human endometrium'. Together they form a unique fingerprint.

Cite this