Abstract
The bioorthogonal synthesis of drugs offers a unique opportunity for targeting — either molecularly, spatiotemporally or both — the delivery of active compounds directly to the disease site. Problems such as unfavorable pharmacokinetic (PK) profiles and dose-limiting side effects can be mitigated with the careful deployment of the tools of biorthogonal chemistry. In order to access medicinal applications, researchers have developed groundbreaking new chemistries for the caging and uncaging, assembly, and molecular targeting of a wide range of clinically approved drugs. This review presents notable examples of bioorthogonal drug synthesis that have emerged from the two main branches of the bioorthogonal field: organic click chemistries and transition-metal-catalyzed reaction
| Original language | English |
|---|---|
| Title of host publication | Abiotic Reactions in Live Environments |
| Editors | J. L. Mascareñas, M. Tomás-Gamasa |
| Publisher | Georg Thieme Verlag KG |
| ISBN (Electronic) | 9783132458277 |
| DOIs | |
| Publication status | Published - 2 Oct 2024 |
Keywords / Materials (for Non-textual outputs)
- bioorthogonal catalysis
- click chemistry
- click-to-release
- transition metals
- prodrug
- chemotherapy
- targeted therapy