The purpose of this registry study was to provide an overview of trends and results of liver transplantation in Europe from 1968 to 2016. This data on liver transplantation (LT) was collected prospectively from 169 centers from 32 countries, in the European Liver Transplant Registry (ELTR) beginning in 1968. This overview provides epidemiological data, as well as information on evolution of techniques, and outcomes in liver transplantation in Europe over more than 5 decades; something that cannot be obtained from only a single center experience. This article is protected by copyright. All rights reserved.