2D and 3D electrospinning technologies for the fabrication of nanofibrous scaffolds for skin tissue engineering: A review

Antonios Keirouz, Michael Chung, Jaehoon Kwon, Giuseppino Fortunato, Norbert Radacsi

Research output: Contribution to journalArticlepeer-review

Abstract

This review provides insights into the current advancements in the field of electrospinning, focusing on its applications for skin tissue engineering. Furthermore, it reports the evolvement and present challenges of advanced skin substitute product development and explores the recent contributions in 2D and 3D scaffolding, focusing on natural, synthetic, and composite nanomaterials. In the past decades, nanotechnology has arisen as a fascinating discipline that has influenced every aspect of science, engineering, and medicine. Electrospinning is a versatile fabrication method that allows researchers to elicit and explore many of the current challenges faced by tissue engineering and regenerative medicine. In skin tissue engineering, electrospun nanofibers are particularly attractive due to their refined morphology, processing flexibility—that allows for the formation of unique materials and structures, and its extracellular matrix‐like biomimetic architecture. These allow for electrospun nanofibers to promote improved re‐epithelization and neo‐tissue formation of wounds. Advancements in the use of portable electrospinning equipment and the employment of electrospinning for transdermal drug delivery and melanoma treatment are additionally explored. Present trends and issues are critically discussed based on recently published patents, clinical trials, and in vivo studies.
Original languageEnglish
Article numbere1626
Number of pages32
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume12
Issue number4
Early online date12 Mar 2020
DOIs
Publication statusPublished - 5 Jun 2020

Keywords

  • electrospinning
  • wound healing
  • portable electrospinning, three-dimensional
  • tissue engineering

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